Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0519030 (Klebsiella)
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The prevalence of viral, bacterial and parasitic pathogens among children of Jeddah, Saudi Arabia, was investigated. During December 1995-October 1996, 576 faecal samples were collected from children (0-5 year(s) old) suffering from acute diarrhoea and attending hospitals and outpatient clinics in Jeddah. One or more enteropathogen(s) were identified in 45.6% of the stool specimens. Mixed infections were detected in 12.2% of the diarrhoeal cases. Rotavirus was detected in 34.6% of the specimens of the hospitalized patients and in 5.9% of the specimens of the outpatients. Fifty-one percent of the rotavirus-positive specimens were long electropherotype, 26% were short electropherotype, and 23% could not be electropherotyped specifically. Among those of the long electropherotype, there were six patterns; and of the short electropherotypes, there were four patterns. Serotyping of these specimens revealed a distribution of 39.6%, 4.2%, 6.3%, and 15.6% for rotavirus serotype 1, 2, 3, and 4 respectively. Mixed serotypes were found in 3.1%, and 31.3% of the specimens were untypeable. Other aetiologic agents recognized included Escherichia coli (13%), of which 3.8% were enteropathogenic E. coli (EPEC) and 1.9% enterohaemorrhagic E. coli. Among the E. coli (EPEC) serotypes, O111:K58:B4, O55:K59:B11, and 0127:K63:B8 were found in 31.8%, 18.2%, and 13.6% of the cases respectively. Serotype 026:K60:B6, 0124:K72:B17, and 0112:K66:B11 each was found in 9.1% of the EPEC cases. 0128:K67:B12 and 0125:K70:B13 each was found in one case only. Other detected pathogens were: Klebsiella pneumoniae (4%), Giardia lamblia (3.1%), Salmonella sp. (3%), Shigella flexneri (2.6%), Entamoeba histolytica (2.2%), Trichuris trichiura, Hymenolepis nana, and Ascaris lumbricoides (0.7% each), and Candida albicans (0.5%). Based on the results of this study, it is concluded that the high prevalence of the various enteropathogens among young children is a significant public health problem.
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PMID:Prevalence of viral, bacterial and parasitic enteropathogens among young children with acute diarrhoea in Jeddah, Saudi Arabia. 1139 80

Quinolone resistance encoded by the qnr gene and mediated by plasmid pMG252 was discovered in a clinical strain of Klebsiella pneumoniae that was isolated in 1994 at the University of Alabama at Birmingham Medical Center. The gene codes for a protein that protects DNA gyrase from quinolone inhibition and that belongs to the pentapeptide repeat family of proteins. The prevalence of the gene has been investigated by using PCR with qnr-specific primers with a sample of more than 350 gram-negative strains that originated in 18 countries and 24 states in the United States and that included many strains with plasmid-mediated AmpC or extended spectrum beta-lactamase enzymes. qnr was found in isolates from the University of Alabama at Birmingham only during 6 months in 1994, despite the persistence of the gene for FOX-5 beta-lactamase, which is linked to qnr on pMG252. Isolates from other locations were negative for qnr. The prevalence of mcbG in the same sample was also examined. mcbG encodes another member of the pentapeptide repeat family and is involved in immunity to microcin B17, which, like quinolones, targets DNA gyrase. A single clinical isolate contained mcbG on a transmissible R plasmid. This plasmid and one carrying the complete microcin B17 operon slightly decreased sparfloxacin susceptibility but had a much less protective effect than pMG252. Plasmid-mediated quinolone resistance was thus rare in the sample examined.
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PMID:Prevalence of plasmid-mediated quinolone resistance. 1254 59