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In a series of 1,216 Kaunas school-children aged 10-15 years, a study was conducted of risk factors for atherosclerosis and ischaemic heart disease (elevated blood pressure, overweight, reduced physical activity, and smoking), and of the influence of nonmedicamentous measures on the risk factors' level. After three-years intensive health education concentrated on school-children and their parents, the number of smokers and subjects with reduced physical activity among school-children significantly decreased and the number of overweight school-children also dropped in the preventive intervention district, compared to the control district. The study showed the need for regular examinations of school-children for detecting the presence of risk factors, and the effectiveness of primary non-medicamentous prevention of atherosclerosis and ischaemic heart disease, carried out from school-age.
Cor Vasa 1985
PMID:Preventive study of atherosclerosis and ischaemic heart disease risk factors among Kaunas school-children. 405 13

The purpose of the study was to determine the prevalence of such ischaemic heart disease (IHD) risk factors as cigarette smoking and overweight, and the degree of IHD risk in the Polish and Slovak populations. The investigated population consisted of men aged 45-54 years; 2944 of them were from industrial plants in Warsaw, with response rate of 88.4%, and 698 from plants in Bratislava (response rate: 64.5%). 60.4% of the Warsaw group were cigarette smokers, with average daily consumption of 12.7 cigarettes; the respective values in the Bratislava group were lower (46.4%; 9.2 cigarettes). The mean body weight and the prevalence of overweight were higher in Bratislava (79.6 kg; 25.6%) than in Warsaw (77.9 kg; 20.8%). The IHD risk evaluated according to the multilogistic function was higher in Bratislava. It is concluded that the difference in the IHD death rate found in these cities could to a high extent be explained by the difference in the prevalence of risk factors.
Cor Vasa 1983
PMID:Prevalence of ischaemic heart disease risk factors in male population aged 45-54 years in Warsaw and Bratislava. Part III: Smoking and overweight. 665 26

The aim of the study was to investigate the relationship between IHD and nutrition. 404 occupationally active men in Warsaw aged 45-54 years, and 634 men in Bratislava were screened. The dietary habits of both populations were evaluated on the basis of their dietary history. Although no significant correlation between the daily frequency of basic meals consumption and the prevalence of hypercholesterolaemia, overweight and hypertension was found, a tendency to higher prevalence of these risk factors among people consuming only 2 meals daily was observed in both populations. In the Bratislava population, which was characterized by a lower frequency of basic meals consumption, higher consumption of meat, meat products and fat, a higher prevalence of overweight, hypercholesterolaemia and hypertension was found. The authors conclude that the influence of unproper dietary habits characteristic of industrialized countries, on the health of their populations cannot be completely neglected.
Cor Vasa 1984
PMID:Prevalence of ischaemic heart disease risk factors in male populations aged 45-54 years in Warsaw and Bratislava. Part IV: Relationship between dietary habits and IHD risk factors. 672 18

The fat cell volume from subcutaneous adipose tissue of the anterior abdominal wall has been evaluated in 10 male patients with essential hypertension and in 10 male normotensive control subjects of normal body weight as well as in 9 male obese hypertensives. In both groups with normal weight no significant differences could be confirmed whereas in hypertensives with overweight the adipose cell volume was significantly increased. Thus, no evidence of enlarged adipocytes as a primary defect in patients with high blood pressure could be obtained. The results are discussed in view of obesity, hyperlipoproteinaemia (HLP), increased lipolysis, impaired glucose tolerance, and high insulin response which frequently are associated with essential hypertension and usually favour the accumulation of triglycerides in hepatocytes and adipocytes.
Cor Vasa 1982
PMID:Adipose cell size in patients with essential hypertension. 675 84

The fatty acid pattern of serum triglycerides and FFA in normal untrained subjects, normotensive athletes, patients with labile and stable essential hypertension as well as in hypertensives with overweight and mild hypertriglyceridemia has been evaluated by gas liquid chromatography. The most striking differences revealed the linoleic acid in triglycerides being increased in athletes and in patients with labile hypertension in comparison with normotensive untrained controls and patients with stable hypertension. On the basis of these data an enhanced need of polyunsaturated fatty acids corresponding to probands with high physical activity has been assumed in patients with an early stage of essential hypertension. The differences of arachidonic acid were not so distinct. The results can be relevant with regard to the pathogenetic role of prostaglandin precursors in the development and course of essential hypertension and atherosclerosis.
Cor Vasa 1980
PMID:The fatty acid pattern of serum triglycerides and FFA in patients with essential hypertension of different stages, athletes, and normal subjects. 747 48

Screening for the risk factors of ischaemic heart disease among the male residents of the district of Prague 4 aged 40--49 years was undertaken under the "National multifactorial primary preventive study of myocardial infarction and stroke". Of the 11 091 men invited, 5395 met the defined criteria and were admitted to the study. 58% of them were included in the risk group. The level of attained school education was ascertained at the initial examination. The lowest percentage of persons with hypercholesterolaemia, overweight, elevated blood pressure and smokers was found among university graduates. The results are compared with data of other studies and possible causes of the findings are discussed.
Cor Vasa 1980
PMID:Education and the risk factors of ischaemic heart disease. 747 55

The data of the first 100 patients undergoing heart transplantation in the period between January 1984 and May 1993 were analyzed. Of this group, 57 patients are alive. Out of the total of 43 deaths, 14 patients died from graft failure within the first postoperative days, 6 died from surgical complications, 11 from infection, 10 deaths were due to accelerated coronary atherosclerosis, and 2 patients died from tumours. Early mortality rates (within 30 days since surgery) were 37% and 17% in patients operated on between 1984-88 and between 1989-93, respectively. The health condition of heart transplant recipients is affected by side effects of immunosuppressive therapy. Forty per cent of patients re-develop systemic hypertension within the first post-transplantation year. Five years after transplantation, hypertension is detected in 60% of patients. Elevated serum creatinine levels are present in 70% of patients by the end of the first post-transplantation year. In the ensuing period, there is no progression in renal function impairment, which does not require cyclosporin withdrawal and is not associated with the development of hypertension. In the first post-transplantation year, 45% of patients are markedly obese. All patients with overweight and obesity show markedly raised levels of serum cholesterol. Another undesirable effect (mainly due to corticosteroid therapy) is the development of ulcers in 16% of patients. Heart transplantation has become an established method at the Institute for Clinical and Experimental Medicine in Prague. Despite the above pitfalls, heart transplantation substantially prolongs the life of patients and dramatically alters the quality of their life.
Cor Vasa 1993
PMID:[The patient after heart transplantation]. 814 61


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