Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0497406 (overweight)
 26,365 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to describe the major factors producing variation in levels of serum alanine aminopeptidase. The study population consisted of 1065 men and 1113 women screened at the Center for Preventive Medicine in Vandoeuvre-les-Nancy in 1987. Mean values were significantly higher for men than for women between age 10 and age 55. Alanine aminopeptidase activity was higher in prepubertal children than in adults and decreased with age, but increased again in postmenopausal women. Overweight status had no effect, nor did systolic blood pressure below 160 mmHg. Serum levels fell by 10% for men over this limit, but increased by 15% for women above this limit. Enzyme levels rose with alcohol consumption for both men and women. Men who were heavy smokers (over 20 cigarettes/day) had elevated levels of serum alanine aminopeptidase. In women oral contraceptives and antihypertensive drugs increased enzyme levels. Mean levels increased by 23% in both men and women taking anticonvulsant drugs who also had increased gamma-glutamyltransferase activity. Factors affecting serum alanine aminopeptidase levels, in decreasing order of importance, were sex, age, alcohol consumption, and cigarette smoking.
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PMID:Alanine aminopeptidase in serum: biological variations and reference limits. 289 82