Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0497406 (overweight)
 26,365 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We asked whether there was an association between obesity levels and subsequent THA or TKA using data from 54,406 THA and TKA patients entered into the Canadian Joint Replacement Registry. We compared these patients with a sample of the Canadian population using the Canadian Community Health Survey of 2006. We analyzed information from the Canadian Joint Replacement Registry to quantify the relative risk for THA or TKA in Canada for specific body mass index categories. In reference to the acceptable weight category of body mass index less than 25 kg/m2, the risk for TKA and THA was 3.20- and 1.92-fold higher, respectively, for overweight individuals (body mass index 25-29.9 kg/m2); 8.53- (TKA) and 3.42-fold (THA) higher for those in the obese Class I (body mass index 30-34.9 kg/m2) category; 18.73- (TKA) and 5.24-fold (THA) higher for those identified in obese Class II (body mass index 35-39.9 kg/m2); and 32.73- (TKA) and 8.56-fold (THA) higher for people in obese Class III group (body mass index > 40 kg/m2). Thus, our data support an association between obesity and subsequent THA and TKA.
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PMID:Role of obesity on the risk for total hip or knee arthroplasty. 1828 43

Although the effect of being overweight on the long- and short-term outcome of THA remains unclear, the majority of orthopaedic surgeons believe being overweight negatively influences the longevity of a hip implant. We asked whether complications and long-term survival of cemented THA differed in overweight patients (body mass index [BMI] > 25 kg/m2) and obese patients (BMI > 30 kg/m2) compared with normal-weight patients (BMI < 25 kg/m2). We retrospectively analyzed 411 consecutive patients (489 THAs) treated with cemented THA between 1974 and 1993. Except for cardiovascular comorbidity, we observed no differences in demographics among these weight groups. We found no differences in the number of intraoperative or postoperative complications. The survival rates for the three BMI groups were similar. The 10-year survival for any revision was 94.9% (95% confidence interval, 91.6%-98.2%), 90.4% (95% confidence interval, 85.6%-95.2%), and 91% (95% confidence interval, 81.2%-100%) for normal-weight, overweight, and obese patients, respectively. Cox regression analysis showed BMI and weight had no major influence on survival rates. The differences in mean Harris hip score at final followup were 4.8 between normal-weight and overweight patients and 7.1 between normal-weight and obese patients. Being overweight and obesity had no influence on perioperative complication rates in this cohort and did not negatively influence the long-term survival of cemented THA.
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PMID:Is the long-term outcome of cemented THA jeopardized by patients being overweight? 1828 53