Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0494475 (tonic-clonic seizure)
 1,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
TUBA3D 13.0
KCNIP1 11.4
KCNAB2 11.2
JAE 10.5
alpha-4 integrin 10.5
KIAA2022 10.5
EJM1 10.2
SMEI 10.2
SCN3B 10.0
SCN4B 10.0
CSNK2B 9.9
KCNMB1 9.8
CTSH 9.8
SCN2B 9.7
ADLTE 9.5
protocadherin 19 9.5
GNAI2 9.4
NGK2 9.2
EFHC1 9.1
GRIK1 9.0
TBC1D24 8.9
Voltage-gated sodium channel 8.9
ARRB2 8.8
ALX4 8.7
PRES 8.5
DPP6 8.3
JUP 8.3
laforin 8.3
ITPR1 8.2
CHRNB2 8.1
nitric oxide synthase 1 8.1
IGE 8.1
NifU 8.0
DRPLA 7.9
leu5 7.7
EPM2A 7.7
SCN1A 7.6
ABCD1 7.6
Complement C3 7.6
ST-2 7.6
ubiquitin protease 7.4
renal dipeptidase 7.4
McLeod syndrome 7.4
ATP1A2 7.3
SCN9A 7.2
MICE 7.2
KRIT1 7.2
PARS 7.1
CCM3 7.1
CCM2 7.0
KA2 7.0
CCM1 6.9
galactose-1-phosphate uridyltransferase 6.8
mGluR8 6.7
malin 6.7
AED 6.7
jerky 6.7
NBP 6.6
COL4A1 6.6
GBP 6.6
AQP9 6.5
pseudocholinesterase 6.4
PHD finger 6.4
Cx36 6.4
nephropathic cystinosis 6.3
Y5 receptor 6.3
SSTR5 6.3
KCNH2 6.3
SNX 6.2
CLN 6.2
Nav1.7 6.2
NER 6.1
Cav2.1 6.1
OPD 6.1
ClC-2 6.0
vesicular glutamate transporter 2 6.0
neuronal nicotinic acetylcholine receptor 6.0
WFS1 6.0
histamine H3 receptor 5.9
NOS1 5.9
CAE 5.9
dual-specificity phosphatase 5.8
fumarate hydratase 5.8
HCN1 5.7
Metalloproteinase 5.7
CLN3 5.7
cannabinoid receptor 1 5.6
Y2 receptor 5.6
CPS 5.6
PHP 5.5
ATA 5.5
P32 5.5
muscle creatine kinase 5.4
gamma-amino butyric acid 5.4
Trio 5.4
Kv4 5.4
She 5.4
MEN1 5.4
fatty acid amide hydrolase 5.3
NPS 5.3
voltage-gated sodium channel 5.3
hexosaminidase A 5.3
PPG 5.3
CD45R 5.3
CPR 5.3
SS-B 5.2
PME 5.2
coagulation factor VIII 5.1
X-linked adrenoleukodystrophy 5.1
IP1 5.1
glucuronosyltransferase 5.1
NSD 5.1
C-X-C chemokine receptor type 4 5.1
thyrotropin receptor 5.1
ubiquitin-like protein 5.1
NOS3 5.0
monoacylglycerol lipase 5.0
HERG 5.0
voltage-gated potassium channel 5.0
SS-A 5.0
strabismus 5.0
NKA 4.9
PND 4.9
ALD 4.9
AQP4 4.9
ecto-5'-nucleotidase 4.9
P60 4.8
interferon-beta 4.8
SWS 4.8
MRI 4.8
MECP2 4.8
neurotransmitter receptor 4.8
C1 inhibitor 4.8
cannabinoid receptor 4.8
HBA 4.7
parathormone 4.7
CBF 4.7
P14 4.7
myelo 4.6
BIS 4.6
kappa opioid receptor 4.6
ADAMTS13 4.6
NOS2 4.6
OTC 4.5
14-3-3 protein 4.5
IDH 4.5
GABA 4.5
P25 4.5
CA4 4.4
BK channel 4.4
5-HT2C 4.4
troponin I 4.4
GAD67 4.4
CCT 4.3
P15 4.3
TTP 4.3
TPP 4.2
MES 4.2
GABA(B) receptor 4.2
CSF 4.2
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Disease
Lymphoplasmacyte-rich meningioma 13.6
grand mal epilepsy 13.0
Benign focal epilepsy of childhood 12.6
Secondary generalized epilepsy 12.6
moria 12.0
immobility syndrome 12.0
Benign myoclonic epilepsy in infancy 11.8
Orbital hemorrhage 11.6
Intracranial abscess 11.6
Benign Familial Neonatal Convulsions 11.6
EFMR 11.4
Fumarase deficiency 11.2
EGMA 11.1
sleep epilepsy 11.0
Orofacial dyskinesia 10.9
Lennox syndrome 10.8
Idiopathic epilepsy 10.7
Spastic quadriplegia 10.7
Dialysis disequilibrium syndrome 10.6
Musicogenic epilepsy 10.5
petit mal 10.5
Neuroschistosomiasis 10.4
Borjeson-Forssman-Lehmann syndrome 10.4
Parietal lobe 10.3
EJM1 10.2
tonic-clonic status epilepticus 10.2
TORCH syndrome 10.1
anxiety attack 10.1
Porencephaly 10.1
Clonic seizures 10.0
juvenile myoclonic epilepsy 9.8
SUDEP 9.7
atonic seizure 9.7
Jacksonian seizures 9.6
Nonconvulsive status epilepticus 9.5
Gestational choriocarcinoma 9.5
Kennedy syndrome 9.3
Neurogenic pulmonary edema 9.2
racing thoughts 9.2
generalized seizure 9.2
Cerebral vasculitis 9.2
pressured speech 9.2
Cortical blindness 9.1
Water intoxication 9.0
inv(X) 9.0
Recurrent seizures 9.0
follicular small cleaved cell lymphoma 8.9
Limbic encephalitis 8.9
Epilepsia partialis continua 8.8
salivary gland adenocarcinoma 8.8
Lobstein 8.7
delusions of persecution 8.7
Generalized epilepsy 8.7
Mollaret's meningitis 8.7
psychomotor epilepsy 8.6
chronic brain syndrome 8.5
ovarian cancer stage 8.5
giant cell glioblastoma 8.5
Reversible posterior leukoencephalopathy syndrome 8.5
IGE 8.3
Protein C deficiency 8.3
SIADH 8.3
Uncontrolled hypertension 8.3
myoclonus epilepsy 8.3
Acute encephalopathy 8.2
Klebsiella pneumoniae infection 8.2
berry aneurysm 8.2
Gliosarcoma 8.1
solvent abuse 8.1
Male hypogonadism 8.1
hypo-osmolality 8.1
febrile convulsions 8.0
Fahr's disease 8.0
pseudopseudohypoparathyroidism 7.9
McLeod syndrome 7.9
Cranial nerves 7.9
Cranial nerves 7.9
Gliomatosis cerebri 7.9
complex partial seizures 7.8
status epilepticus 7.7
Hippocampal sclerosis 7.7
classical migraine 7.7
hypertensive encephalopathy 7.7
muscle swelling 7.7
blepharophimosis 7.6
IgG subclass deficiency 7.5
SME 7.5
LBD 7.5
Amniotic fluid embolism 7.5
generalized tuberculosis 7.4
eclampsia 7.4
Amniotic fluid embolism 7.4
obstipation 7.4
Landau-Kleffner syndrome 7.3
audiogenic seizure 7.3
Cerebral venous sinus thrombosis 7.1
CCM3 7.1
epilepsy 7.1
GEFS+ 7.1
esophageal ulceration 7.1
reflex epilepsy 7.1
reactive airway disease 7.1
Neurocysticercosis 7.1
echolalia 7.1
Lennox-Gastaut syndrome 7.1
focal epilepsy 7.1
LQT2 7.1
Secondary hyperparathyroidism 7.0
CCM2 7.0
Kugelberg-Welander 7.0
pansinusitis 7.0
global aphasia 6.9
hereditary fructose intolerance 6.9
Insulinoma 6.9
eosinopenia 6.9
meningoencephalomyelitis 6.8
leukoencephalopathy 6.8
Herpes simplex encephalitis 6.8
Lennox-Gastaut syndrome 6.8
mutism 6.8
Parvovirus B19 infection 6.8
esthesioneuroblastoma 6.7
DRESS syndrome 6.7
bone neoplasm 6.7
Endometrium 6.7
Endometrium 6.7
encephalomalacia 6.7
normocytic anemia 6.7
hallucinosis 6.6
dysphasia 6.6
CAE 6.6
color blindness 6.6
Cerebral venous thrombosis 6.6
derealization 6.6
Rosai-Dorfman disease 6.6
incoherence 6.5
temporal lobe epilepsy 6.5
CAE 6.5
ear infection 6.5
status asthmaticus 6.5
acanthocytosis 6.5
mitochondrial encephalomyopathy 6.5
reactive depression 6.5
acute pulmonary edema 6.5
hypoglycemic coma 6.5
high-grade lymphomas 6.5
Adult-onset Still's disease 6.5
scleromyxedema 6.5
mitochondrial myopathy 6.4
PME 6.4
oligodendroglioma 6.4
sparganosis 6.4
bilateral cataracts 6.4
polyclonal hypergammaglobulinemia 6.4
schizencephaly 6.4
pseudobulbar palsy 6.4
tobacco abuse 6.4
MELAS 6.4
DNT 6.3
Canavan 6.3
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Symptom
tonic-clonic seizure 14.6
disturbed speech 10.6
Mental status changes 10.3
Pyramidal signs 10.0
partial seizure 9.6
Todd's paralysis 9.2
tonic seizure 8.8
thoracic back pain 8.8
eye discharge 8.5
myoclonus 8.1
arm weakness 8.0
clonus 8.0
seizures 7.8
Visual disturbances 7.7
facial droop 7.6
asterixis 6.9
rales 6.8
pedal edema 6.8
Cushingoid 6.8
Cushingoid 6.7
forgetfulness 6.7
auditory hallucination 6.5
athetosis 6.5
abdominal cramps 6.5
lethargy 6.5
personality change 6.4
twitching 6.4
neck stiffness 6.3
loin pain 6.2
catatonia 6.0
prostration 6.0
consciousness disturbance 5.9
hypertonia 5.9
dysarthria 5.8
loss of balance 5.7
paraparesis 5.7
Halo 5.7
arm pain 5.6
ataxic gait 5.5
polydipsia 5.4
hemiplegia 5.4
headache 5.4
dizziness 5.3
vomiting 5.3
tachypnea 5.2
sleepiness 5.2
atypical chest pain 5.2
hypotonia 5.2
syncope 5.2
drooling 5.2
blurred vision 5.1
ataxia 5.1
agitation 5.0
sciatica 5.0
rigors 4.9
enuresis 4.9
paresis 4.9
neuralgia 4.8
incoordination 4.8
cerebellar ataxia 4.7
muscle cramps 4.7
cyanosis 4.7
dysesthesia 4.7
nausea 4.6
dry skin 4.6
blepharospasm 4.6
chorea 4.5
ophthalmoplegia 4.4
abnormal gait 4.4
stridor 4.4
bradykinesia 4.4
insomnia 4.4
night sweats 4.3
dental pain 4.3
memory loss 4.3
muscle stiffness 4.3
dysuria 4.3
paresthesia 4.3
fasciculation 4.2
shoulder pain 4.1
weakness 4.1
hepatosplenomegaly 4.0
anosmia 4.0
polyuria 4.0
physical appearance 4.0
photophobia 3.9
nausea and vomiting 3.9
myalgia 3.9
hip pain 3.7
oliguria 3.7
leg pain 3.6
tremor 3.6
skin irritation 3.5
spasticity 3.5
back pain 3.3
pallor 3.3
numbness 3.2
hypercapnia 3.2
anorexia 3.1
dystonia 3.1
knee pain 3.1
anesthesia 3.1
collapse 3.1
hemoptysis 3.0
cancer pain 3.0
acute abdomen 3.0
dyspnea 3.0
low back pain 2.9
epigastric pain 2.8
abdominal pain 2.6
respiratory distress 2.6
neck pain 2.6
apathy 2.6
diarrhea 2.6
chills 2.5
chest pain 2.5
fatigue 2.4
splenomegaly 2.3
hunger 2.1
hepatomegaly 2.1
analgesia 1.8
vertigo 1.8
discomfort 1.7
discomfort 1.6
hypothermia 1.5
pain 1.3
constipation 1.2
angina 1.2
Ill 1.1
thinning 1.1
cough 1.0
erythema 0.9
functional recovery 0.8
exhaustion 0.8
Drug
Liskantin 13.6
Disipal 12.6
Cyclogyl 11.8
Disipal 11.8
Cyclogyl 11.4
Sulthiame 11.3
Carbatrol 10.4
Talwin 9.9
Zotepine 9.2
Talwin 9.2
Demerol 9.1
Rocaltrol 9.1
Dilantin 8.8
Stiripentol 8.8
Sodium valproate 8.6
Demerol 8.5
Cordarone 8.4
Planum 8.3
Camphor 8.0
Camphor 7.9
Pantopaque 7.8
Chlorothiazide 7.5
Metrizamide 7.4
Diamox 7.2
L-Asparaginase 7.1
Moclobemide 7.0
Bactrim 6.9
Ethane 6.9
Iopamidol 6.6
Magnesium sulfate 6.5
Phenytoin 6.5
Duloxetine 6.3
Mirtazapine 6.3
Kainic acid 6.2
Filgrastim 6.1
TRM 6.0
Trimethoprim-sulfamethoxazole 6.0
Natalizumab 6.0
Filgrastim 5.9
CPR 5.8
LCM 5.8
LCM 5.8
Moxifloxacin 5.7
DDAVP 5.7
Isoniazid 5.6
DDAVP 5.6
Prednisone 5.6
Piperacillin 5.6
Salicylate 5.4
Urokinase 5.3
Cremophor EL 5.3
DPA 5.2
Pilocarpine 5.2
Domperidone 5.2
Propofol 5.1
OTC 5.0
OTC 4.5
Etoposide 4.4
CoCl2 4.3
CoCl2 4.3
Vitamin B 4.3
HCG 4.2
IPM 4.0
CSF 3.8
caffeine 3.6
uPA 3.5
Ouabain 3.3
Nitric Oxide 3.2
Rituximab 3.1
Atropine 2.9
PCP 2.7
niacin 2.7
Spectrum 2.6
Adriamycin 2.4
Ethanol 2.3
CTX 2.2
G-CSF 2.2
CaCl2 1.9
CaCl2 1.9
CaCl2 1.9
ABC 1.4
ampicillin 0.5
Monit 0.5
IL-2 -0.3
lysine -1.3
Dermatol -2.4
Cardiovasc -3.0
Enzyme
glycerol-3-phosphate oxidase 7.9
PME 6.0
CPS 5.3
BIS 4.7
nucleotidase 4.6
fumarase 4.4
TPP 4.2
CPR 4.2
TPP 4.1
ornithine transcarbamylase 3.8
aldolase 3.8
glycerol-3-phosphate dehydrogenase 3.8
tryptophan hydroxylase 3.8
glycerol-3-phosphate dehydrogenase 3.7
ADH 3.4
MDP 3.2
diaphorase 3.1
thyroid peroxidase 3.0
UDP-glucuronosyltransferase 2.9
hexosaminidase 2.8
enolase 2.7
PCP 2.7
NADPH-diaphorase 2.6
creatine kinase 2.4
adenosine deaminase 2.2
adenosine deaminase 2.2
monoamine oxidase 2.2
diaphorase 2.0
AST 2.0
NQO1 2.0
cholinesterase 1.9
ATP synthase 1.8
carbonic anhydrase 1.7
thymidine kinase 1.7
glucose-6-phosphate dehydrogenase 1.6
xanthine oxidase 1.5
alanine aminotransferase 1.4
gamma-glutamyl transpeptidase 1.4
topoisomerase 1.4
alcohol dehydrogenase 1.4
lipase 1.4
glutathione reductase 1.3
CD10 1.3
topoisomerase 1.3
aspartate aminotransferase 1.2
tissue plasminogen activator 1.1
thromboplastin 0.9
P-glycoprotein 0.9
tyrosine hydroxylase 0.7
alkaline phosphatase 0.6
APC 0.6
ACE 0.4
glutathione peroxidase 0.1
acetylcholinesterase -0.2
lactate dehydrogenase -0.3
superoxide dismutase -0.3
caspase-3 -0.6
protein kinase C -1.0
catalase -1.2
ATPase -1.4
peroxidase -1.4
protein kinase -1.8
mitogen-activated protein kinase -2.0
Compound
ZAPA 10.9
Dionosil 10.4
Clorazepate 9.8
CZP 9.8
Bupropion hydrochloride 9.8
Cyclopentolate 9.7
Primidone 9.5
Tetramethylenedisulfotetramine 9.4
Orphenadrine 9.2
CI-921 9.1
Methohexital 8.8
Felbamate 8.4
Methomyl 8.3
IGE 8.0
Fleroxacin 7.8
Camphor 7.8
suberic acid 7.8
Clonazepam 7.8
Phenylpropanolamine 7.8
Phenylpropanolamine 7.7
Desmopressin 7.6
Clobazam 7.4
4-pentenoic acid 7.3
Tiagabine 7.2
Ethosuximide 7.2
Levetiracetam 7.2
Meperidine 7.2
Mefloquine 7.1
Mefloquine 7.1
Oxcarbazepine 7.0
Lorazepam 6.8
Dimethylhydrazine 6.8
Ropivacaine 6.7
Pentazocine 6.6
Moxalactam 6.6
Harman 6.5
Mirtazapine 6.5
Ibotenic acid 6.5
Ibotenic acid 6.5
DPH 6.4
Magnesium sulfate 6.4
Valproic acid 6.4
Bupropion 6.4
Chlorambucil 6.4
Olanzapine 6.3
Magnesium sulfate 6.3
Phenylbutazone 6.2
Rosmarinic acid 6.2
Rosmarinic acid 6.2
Alprazolam 6.2
Kainic acid 6.2
Kainic acid 6.2
Valproic acid 6.1
Vigabatrin 6.1
Kynurenic acid 6.0
Lamotrigine 6.0
Pyridoxine 6.0
Hypoxanthine 6.0
Dantrolene 5.9
HCA 5.8
Moxifloxacin 5.8
Evans Blue 5.8
Vincristine 5.7
Venlafaxine 5.7
NBQX 5.7
Cortisone 5.7
Lindane 5.6
Endosulfan 5.6
Picrotoxin 5.6
Picrotoxin 5.6
Flumazenil 5.6
Piperacillin 5.6
Ruthenium red 5.5
methylformamide 5.5
Sulfamethoxazole 5.5
Dynorphin 5.5
m-AMSA 5.5
Aripiprazole 5.5
Quinine 5.5
Tetrahydrocannabinol 5.4
A 71 5.4
Clozapine 5.4
Ondansetron 5.4
Organon 5.4
Lidocaine 5.4
ECS 5.4
Topiramate 5.3
Pilocarpine 5.3
Amitriptyline 5.2
MNU 5.2
Bicuculline 5.2
alpha-ketoisocaproate 5.2
PPA 5.1
Strychnine 5.1
Uracil 5.0
Physostigmine 5.0
Ketanserin 5.0
Propofol 5.0
ATA 5.0
LTE4 4.9
Prednisone 4.9
Muscimol 4.9
Isoproterenol 4.8
Acetazolamide 4.8
Dexmedetomidine 4.8
4-methylphenyl 4.8
cyclopentyl 4.7
Imipenem 4.7
Neurotol 4.7
Ceftriaxone 4.7
A 42 4.6
Yohimbine 4.6
Isoflurane 4.6
Ryanodine 4.5
Penicillin 4.5
CPP 4.5
DPA 4.5
DPA 4.5
4-AP 4.4
methylhistamine 4.4
GABA 4.4
gamma-aminobutyric acid 4.4
CPP 4.4
GABA 4.4
nonyl 4.4
HCI 4.4
Midazolam 4.3
Baclofen 4.3
DPA 4.3
Diltiazem 4.3
Diltiazem 4.3
DPA 4.3
CoQ 4.3
POP 4.3
MK801 4.3
DPA 4.2
MES 4.2
MES 4.2
Penicillin 4.2
Phenylephrine 4.1
TPP 4.1
DPA 4.1
Cocaine 4.1
DPA 4.0
5-HIAA 4.0
DPA 4.0
DPA 4.0
DPA 4.0
DPA 4.0
DPA 4.0
EPSP 4.0
folinic acid 3.8
HVA 3.8
TPP 3.8
INH 3.8
Naloxone 3.7
Luminal 3.7
Gentamicin 3.7
hydroxyindoleacetic acid 3.6
caffeine 3.6
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