Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0494475 (tonic-clonic seizure)
 1,319 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Systemic toxic were encountered in eight of 10,469 patients during or immediately following the intramuscular injection of 4,800,000 units of procaine penicillin G for the treatment of gonorrhea. Fear of imminent death, visual and auditory disturbances, violent combativeness, confusion, disorientation, and restlessness, disturbance in taste, cardiovascular changes, and grand mal seizures are the principal manifestations; these usually subside in two to 10 minutes spontaneously or after treatment. Symptoms and signs closely parallel systemic toxic reactions to local anesthetics. Pharmacokinetic analysis in dogs using 14C-procaine and 14C-procaine penicillin G showed rapid distribution of labeled drugs from plasma to cerebrospinal fluid for the intravenous as compared to the intramuscular route of administration. The animal studies were consistent with the hypothesis that the inadvertent intravenous administration of procaine penicillin G is responsible for the systemic toxic reactions. Plasma procainesterase (pseudocholinesterase) activity was assayed with an ultraviolet spectroscopic method. Substrates were procaine and procaine penicillin G. The plasma procainesterase activity of patients who had experienced systemic toxic reactions was significantly decreased as compared to that of controls, an observation not previously reported.
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PMID:Systemic toxic reactions to procaine penicillin G. 41 9

This is a study of 296 nulliparous women who used copper IUDs as their method of contraception. At the time of the 1st insertion, the women averaged an age of 21.6 years, and the gross cumulative pregnancy rate rose to 11.8 over 5 years. The gross cumulative expulsion rate rose to 13.6 over 5 years and the removal rate for bleeding and pain to 20.4. The net rates were lower over 5 years (pregnancy 8.6, expulsion 11.2, bleeding and pain 17.3). 29 women expelled their IUDs and 20 of them underwent reinsertion. 43 requested removal of their IUDs because of bleeding and pain and 6 of them requested reinsertion at a later date. Taking reinsertions into account, the continuation rate over the 5-year period was 55.2. Inability to insert the IUD was encountered in 28 of the women, or 8.6%. In 20 of the women, cervical stenosis precluded the insertions of the IUD without local anesthetic, and in the other 8 the pain during the sounding of the uterus precluded the continuation of the procedure. Insertion problems were encountered in 31 women (10.5%) and syncope occurred in 4 women, with 1 of them experiencing a grand mal seizure. Clinically significant pelvic infection occurred within 30 days of insertion in 5 women and 1 woman developed pelvic infection from gonorrhea. Over the 5-year study period, there was a good overall continuation rate. However, further study and long-term follow-up are necessary to investigate the fertility of nulliparous IUD users. While all the women in this study who had IUDs removed did conceive (N=10), this number is too small to generalize.
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PMID:Five years private practice experience of nulliparous women using copper IUD's. 738 54