Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0477470 (Other pemphigoid)
 1 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Incidence of bullous pemphigoid (BP), the main pemphigoid disease, has increased over the past decades. Despite growing insights into pathogenic mechanisms, treatment is still based on systemic immunosuppression. Furthermore, overall mortality is significantly increased, which can be at least partially attributed to immunosuppressive therapy. Other pemphigoid diseases are also still difficult to treat. Hence, there is a so far unmet need for novel treatment options in patients with pemphigoid disease. Based on recent advances in understanding pathogenesis, several novel potential therapeutic targets have emerged. Interestingly, for some of these targets, lead compounds have been developed. Here, we review emerging therapeutic targets for pemphigoid diseases and discuss which compounds are likely be used in the future.
Trends Mol Med 2013 Aug
PMID:Emerging treatments for pemphigoid diseases. 2383 38