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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

[PURPOSE]: An attempt was made to evaluate the ability of magnetic resonance (MR) imaging to diagnose stage IIIa endometrial carcinoma. [MATERIALS AND METHODS]: Thirty-three patients with endometrial carcinoma underwent MR imaging and surgery. Surgical staging was classified as I in 21 patients, II in 3 patients and III in 9 patients. The MR images of each patient were retrospectively reviewed by three radiologists. Only the clinical diagnosis of endometrial carcinoma was previously notified. Segmental disruption of the full thickness of the myometrium was considered serosal invasion. Intraperitoneal metastasis was diagnosed according to three criteria (intraperitoneal solid mass of isointensity compared with endometrial lesion, cystic mass excluding benign ovarian cysts, ascites). These evaluations were compared with the surgical findings and analyzed by the kappa statistic. [RESULTS]: The rates of sensitivity and positive predictive value (PPV) for serosal invasion were 33% and 6%, respectively. False positive evaluation frequently occurred when thickness of the intact myometrium was less than 5mm. The rates of sensitivity and PPV for intraperitoneal metastasis were 86% and 72%, respectively. The reason for false negative evaluation was small foci of intraperitoneal metastasis. Overall, sensitivity and PPV for stage IIIa were 86% and 69%, respectively. [CONCLUSION]: MRI was useful in detecting intraperitoneal metastasis of endometrial carcinoma with the exception of diagnosing serosal invasion. It is difficult to detect small foci of peritoneal metastasis. It is necessary to differentiate adnexal metastasis from benign adnexal masses.
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PMID:[Stage IIIa endometrial carcinoma: MR findings]. 869 53

One hundred and sixty patients with FIGO stage I and II endometrial cancer entered this study. Magnetic Resonance Imaging (MRI; 61 cases), fractional curettage (110 cases) and hysteroscopy (119 cases) were performed to evaluate the presence of cervical involvement, and the findings were histologically compared with specimens obtained in abdominal hysterectomy. MRI showed the highest sensitivity (90.9%), specificity (96.0%) and diagnostic accuracy (95.1%) for the presence of cervical involvement. In 11 cases with cervical lesions, MRI predicted all 9 cases with invasion deeper than 1.5 mm. From these results we concluded that MRI appeared to be an excellent technique for cervical involvement and it would be a great help in determining the surgical procedure for endometrial cancer.
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PMID:[Usefulness of magnetic resonance imaging in the determination of cervical involvement in endometrial cancer]. 884 Oct 49

Published studies relating to the use of transvaginal sonography (TVS) in the evaluation of endometrial hyperplasia and carcinoma were reviewed. Approximately 80 percent of all curettage procedures performed for postmenopausal bleeding result in benign diagnoses, therefore, if a noninvasive modality such as TVS can be accurately used to determine endometrial thickness measurements below which pathology is less likely, sampling may be avoided. The largest study evaluating endometrial measurements in postmenopausal women with bleeding, known as the Nordic trial, found that for a cut-off value of < or = 4 mm, 96 percent sensitivity and 68 percent specificity was achieved. Another study evaluated endometrial echomorphology in addition to measurement and found that the combined approach improved the predictability of pathologic findings. TVS may also be used to assess the depth of myometrial invasion in patients already diagnosed histologically with endometrial carcinoma. Although MRI is considered the established tool in the presurgical evaluation of the patient with carcinoma, TVS was found to perform only slightly less accurately than MRI. The published studies regarding TVS and/or MRI are reviewed. Finally, the use of TVS in conjunction with a new modality, sonohysterography, in the evaluation of patients on tamoxifen therapy, is discussed. Although the published cut-off values for endometrial thickness measurements do not apply to this group of patients, a procedure whereby sterile saline is injected into the uterine cavity, via a thin catheter, provides additional information regarding endometrial contours. Once the procedure is performed, the supposed complex endometrial echo seen on TVS is often found to actually be located in the subendometrial myometrium and the endometrium itself is thin and regular. The role for TVS is well established in the search for endometrial hyperplasia and carcinoma, as well as evaluating the presence of myometrial invasion once the diagnosis is made.
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PMID:Use of transvaginal sonography in the evaluation of endometrial hyperplasia and carcinoma. 897 95

In the treatment of locally advanced carcinoma of the uterine cervix the multimodal therapeutic approach is useful to improve overall survival and disease-free survival. Two studies of concomitant radiochemotherapy were conducted. In the first, recurrences of gynecologic tumors were treated, in the second primary tumors of the uterine cervix. In the first study 29 patients, of whom 15 with endometrial cancer recurrence, 10 with cervical cancer recurrence and 4 with vulvar cancer recurrence were treated with FUMIR schedule (5-FU and mitomycin C plus concomitant radiotherapy to the pelvis in two cycles of 23.4 Gy) and subsequent brachytherapy boost. In the second study 17 patients, of whom 14 evaluable, were treated with external beam radiotherapy (ERT 40 Gy) and concomitant chemotherapy (5-FU and CDDP). Before and after treatment the patients were examined with MRI. After radiochemotherapy radical hysterectomy and histology of surgical specimen was performed. Results of first study were as follows: acute G1-G2 (RTOG) hematologic toxicity 56%, G3 4%; G1-G2 gastrointestinal 54%, G1-G2 skin 29%; G1-G2 rectum 24%; G1-G2 bladder 25%; G1-G2 vagina 30%. Local control, overall survival and disease-free survival at 24 months were 45%, 76% and 67%, respectively. Results of the second study showed 9/14 patients with complete response and 4/4 patients with partial response (93%), no change in 1, with 100% MRI accuracy as compared to histology. Based on these results a phase III clinical trial was planned in primary cancer of the uterine cervix using concomitant radiochemotherapy (CDDP + 5-FU) plus intracavitary brachytherapy for organ preservation.
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PMID:Organ preservation in locally advanced carcinoma of the uterine cervix. 944 53

Intraperitoneal and arterial neo-adjuvant chemotherapy were given to one patient with endometrial carcinoma (clear cell adenocarcinoma). She was diagnosed as an inoperable advanced carcinoma (stage IV B) associated with direct invasion of the urinary bladder and pleural effusion. Intraperitoneal infusion therapy with CDDP 100 mg was given every 3 weeks. The patient was also given intra-uterine arterial infusion chemotherapy three times with CDDP and ADM. MRI, CT, and Cystoscopic examinations failed to detect any carcinoma. An optimal operation was performed. In a histological study, the uterine carcinoma was in complete remission. But a degenerative adenocarcinoma was shown at peritoneal dissemination.
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PMID:[A case report: endometrial carcinoma response to intraperitoneal and intraarterial chemotherapy]. 970 19

The value of preoperative diagnostic procedures (FC, hysteroscopy, TVS, MRI, CT) used to evaluate cervical canal involvement in cases of endometrial carcinoma was assessed. The results of these diagnostic methods were compared to postoperative pathologic examination results. Evaluation of the cervix by CT was limited. High NPV of the rest of the methods together with their negative results allowed us to exclude cervical infiltration with a high probability. Alas, none of them was adequate to confirm the presence of cervical involvement because of their low PPV which ranged from 8.3% (hysteroscopy) to 50% (MRI). Among all these diagnostic procedures TVS was relatively efficient (77.8%), specific (78%), sensitive (75%) and inexpensive. This method is preferable in the evaluation of possible cervical infiltration.
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PMID:Fractional curettage, hysteroscopy and imaging techniques: transvaginal sonography (TVS), magnetic resonance imaging (MRI) and computed tomography (CT) in the diagnosis of cervical canal involvement in cases of endometrial carcinoma. 1021 41

The prognosis in patients with gynecologic cancers depends not only on the stage but also on a wide spectrum of other findings. Cross-sectional imaging modalities, including sonography, CT and MRI, have increasingly been used for optimal treatment planning in gynecologic cancers. Their staging criteria are based on the well-established FIGO staging system. CT and MRI compete with sonography, which plays a pivotal role in the evaluation of the female pelvis. This paper reviews the role of sonography, CT and MRI in the staging of gynecologic malignancies. It puts the emphasis on MRI, which has been established as imaging modality of choice in the preoperative evaluation of cervical and endometrial cancer, and which seems slightly superior to CT in the staging of ovarian cancer.
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PMID:[Diagnostic imaging in staging of gynecologic carcinomas]. 1047 90

The diagnostic value of endovaginal sonography in benign or malignant endometrial pathology is high, increased by sonohysterography. Sonohysterography is useful in the diagnosis of endometrial thickness and to determine further investigations. MRI is accurate in the uterine adenomyosis diagnosis and is the imaging modality of choice for the preoperative endometrial cancer staging.
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PMID:[Endometrial imaging]. 1117 54

Endometrial carcinoma is a rare iatrogenic complication due to the adverse estrogenic like effect of Tamoxifen on the uterine mucosa. We report the delayed case of an endometrial carcinoma after an unusual twleve year long daily administration of Tamoxifen (cumulative dose = 131 g). Endovaginal contrast ultrasound examination (Levovist, Schering, Germany) and MRI appearances are described.
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PMID:[132 grams of tamoxifen: ultrasonographic and MRI appearance of endometrial carcinoma]. 1189 49

Endovaginal sonography in combination with HSG is an effective screening tool in evaluating patients with postmenopausal bleeding. Endovaginal sonography is highly sensitive for detecting endometrial carcinoma and can identify patients at low risk for endometrial disease obviating the need for endometrial sampling in this subgroup of patients. In patients with abnormal findings at sonography, a detailed morphologic analysis can be used to determine which patients can undergo blind endometrial sampling successfully versus those who would benefit from hysteroscopic guidance. In patients in whom endovaginal sonography and HSG are inadequate, MRI may provide additional information on the appearance of the endometrium, particularly in patients in whom endometrial sampling is difficult (eg, patients with cervical stenosis).
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PMID:Postmenopausal bleeding: value of imaging. 1211 92


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