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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The incidence of endometrial cancer during the menopausal period as a result of therapy involving the use of estrogens, such as estrone, estradiol, and estriol, is examined on the basis of current literature and material obtained from international symposiums. This problem has normally been analyzed by a determination of the estrogen balance and metabolism. Indications linking estrogens with carcinoma have been in regard to the dosage and type of estrogen, and the length, nature (interrupted or continuous), and type (cyclical or not) of administration. The risk of endometrial carcinoma is found to increase accordingly with the length of treatment, and if it is uninterrupted. The risk is found to be diminished only in cases of cyclical therapy, with period interruptions. The alarming rates of endometrial cancer found in menopausal users of estrogens is noted to be primarily an American phenomenon, not noted with Polish preparations and therapeutic techniques.
Pol Tyg Lek 1977 Jul 18
PMID:[Risk of endometrial carcinoma in women receiving estrogens in menopause]. 89 56

Expression of a c-myc proto-oncogene product known as p62 (c-myc) was studied in 18 cases of stage I endometrioid (typical) adenocarcinoma of the uterus by immunohistochemistry and correlated with mucin production and other pathologic features. Cytoplasmic staining of tumor cells for c-myc product was seen in all cases and nuclear staining in three cases. Endometrial stromal cells were invariably negative and myometrial nuclear staining was seen in three cases. Within the tumor itself, whereas intense staining was frequent in high grade tumors with deep myometrial and vascular invasion, faint to moderate staining was frequent in well differentiated tumors with superficial myometrial invasion. A general tendency was also seen for greater staining in the myometrial component of the tumor than in tumor located in the endometrium. Whereas staining in the latter was frequently patchy in distribution, c-myc expression was invariably uniform in the myometrial component. Mucin production was somewhat greater in endometrial than myometrial components but did not correlate with c-myc expression or other pathologic features. This study demonstrates that c-myc is variably expressed in endometrial carcinoma and high c-myc expression can be associated with populations of tumor cells selectively capable of myometrial and vascular invasion.
Mater Med Pol
PMID:C-myc gene expression in stage I endometrioid adenocarcinoma of the uterus. 130 72

The influence a few factors on prognosis on 5-th year survival has been estimated in 367 patients with endometrial cancer with stage I, II and III disease which underwent surgery and radiotherapy. The stage is the most important and competent authority indicators of prognosis on 5-th year survival, among prognostic variables for endometrial carcinoma the most important have been identified as: 1) histologic type, 2) grading, 3) depth of myometrial invasion. The 5 year survival appeared correlated with the age of patients survival of patients younger than 59 years of age was higher and statistically significant.
Ginekol Pol 1994 Sep
PMID:[Prognostic survival of women after surgery for endometrial cancer]. 772 Nov 60

The estrone concentration was estimated in tissue of endometrial cancer and in the serum of 103 postmenopausal women. Patients were divided into two subgroups: normal body mass and overweight (above 130% of ideal body mass). The mean (+/- SED) tissue estrone concentration in women with normal body mass was 0.54 +/- 0.06 pmol/g tissue and did not differ from that of overweight. Tissue estrone concentration correlated positively with Broc Index in subgroup with normal body mass and not in overweight.
Ginekol Pol 1994 Sep
PMID:[Estrone concentration in endometrial cancer tissue in relation to body mass]. 772 Nov 61

Two dimensional polyacrylamide gel electrophoresis of 3' end labeled total tRNA from primary and secondary (metastatic) endometrial cancer was used to obtain mapping of isoacceptors. In tRNA from primary tumor 87 isoacceptors were found whereas in metastatic cancer only 52 spots corresponding to isoacceptors were detected. Normal myometrial tRNA used as a control contained 51 isoacceptors. The isoacceptors specific for neoplasia were observed in both cancer tRNAs.
Ginekol Pol 1994 Dec
PMID:[Transfer RNA (tRNA) in primary and metastatic endometrial cancer tissue]. 778 63

Two women with endometrial cancer and precancerous lesion treated with medroxyprogesterone are presented. In both patients outcome of neoplasm is obtained.
Ginekol Pol 1994 Jun
PMID:[Conservative treatment of two young women with cancer and precancerous lesions of the endometrium]. 798 38

Modern methods enabling evaluation of endometrium in all phases of the menstrual cycle were presented. Transvaginal ultrasound does not give characteristic pictures. The most frequently observed sonographic features in endometrial hyperplasia and endometrial carcinoma were compared. Most frequently, in 29% we observed the thickening of the endometrium. The enlargement of the uterine body was detected in 27%. The dominant feature in endometrial carcinoma was distortion or lack of medium-focus echo-90%. Different echogenicity was observed in 69% of all cases. Application of hysteroscopy enables us to visualize changed endometrium and also to sample focal lesions for histopathological examination. Endometrial carcinoma was detected in all analyzed cases with application of hysteroscopy and ultrasound. Pathological endometrial hyperplasia was diagnosed by ultrasound only in 44% and with application of hysteroscopy in 84% of all material.
Ginekol Pol 1993 Sep
PMID:[Usefulness of transvaginal ultrasound and hysteroscopy in diagnosing endometrial hyperplasia and endometrial carcinoma]. 814 53

Preoperative transvaginal ultrasonographic evaluation of myometrial invasion was performed in 33 patients with endometrial cancer and compared with histologic findings. TVU was remarkably precise in predicting deep myometrial invasion (accuracy 91.7%) but superficial myometrial invasion (sensitivity 20%). TVU was highly accurate in patients with tumours limited to the endometrium (sensitivity 100%) and the sensitivity of TVU in distinguishing nil or superficial versus deep invasion was 87.8%. TVU appears to be an efficient, economic, and practical tool for this purpose, however its limitation leads to more complex imaging techniques, especially in patients in whom preoperative irradiation or conservative management is planned.
Mater Med Pol
PMID:Preoperative assessment of myometrial invasion of endometrial carcinoma by transvaginal ultrasonography. 856 72

Our results were compared with the results from numerous recent studies concerning important risk factors for the endometrial carcinoma. We revealed that only age more then 50 with conjunction with obesity is the important risk factor. We didn't proved the protection role of the pregnancy emphasized in the literature. The role of others epidemiologic risk factors for the endometrial carcinoma remains still unequivocally explained.
Ginekol Pol 1996 Jan
PMID:[Major risk factors for endometrial carcinoma]. 865 15

Cyclical mastalgia which almost 40% of women suffer from is caused by inadequate ovarian hormones secretion. There are reports regarding increased number of endometrial steroid receptors in this group of women. The possibility of higher risk of endometrial cancer development in these women is very probable. 119 women with cyclical mastalgia aged 16-55 (means age 35.4 years) were investigated. Anovulatory cycles occurred in 63%. Increased estrogen action in vaginal smears was found in 24.1%, also decreased progesterone effect had been seen in 20.3% of our cases. Serum estradiol levels were elevated in 10.6% and 39.1% of the patients had lower serum progesterone levels. Mean progesterone--estrogen luteal index value was decreased to 0.99. Irregular uterine bleedings occurred in 16.8 of women (aged 41-48 years). Histological endometrium examinations revealed changes due to insufficient progesterone action.
Ginekol Pol 1995 Aug
PMID:[Evaluation of endometrial changes in women with cyclical mastalgia]. 867 69


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