Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mutation of neoplastic tumor suppressor genes, scribble, discs large, and lethal giant larvae (lgl), causes disruption of cell polarity and overproliferation of Drosophila epithelial cells and neuroblasts. Reduced expression of human homologue of lgl,
Hugl-1
, has been reported to be involved in development and progression of human colon cancer and malignant melanoma. To explore the association between
Hugl-1
expression and clinical character in
endometrial cancer
, we examined the expression of
Hugl-1
in primary
endometrial cancer
tissues. The expression of
Hugl-1
mRNA in 86 primary
endometrial cancer
tissues was examined using semiquantitative reverse transcription polymerase chain reaction (RT-PCR). All samples were categorized into two groups:
Hugl-1
positive and
Hugl-1
negative. Clinical data of each group were analyzed by Fisher's exact probability test and survival rates of each group were compared by Kaplan-Meier method and Log-rank test. Loss of
Hugl-1
expression had correlation with the higher incidence of lymph node metastasis, but not to the patient's age at onset, distant metastasis, clinical stage, lymph or venous vessel invasion, or histopathological grade of differentiation. The
Hugl-1
-positive group had poorer prognosis compared with the
Hugl-1
-negative group. These results indicate that loss of
Hugl-1
expression in
endometrial cancer
may contribute to lymph node metastasis and it can be a factor of poor prognosis.
...
PMID:Loss of Hugl-1 expression associates with lymph node metastasis in endometrial cancer. 1807 78
