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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Menopausal disorders coincide with the onset of luteal insufficiency and the resulting relative hyperestrogenism. At this stage the risks to be assessed are mainly related to a worsening of the menstrual syndrome (heaviness of the legs, abdominal distention, water retention, mastodynia, depressive syndrome), cycle changes, or various genital types of hemorrhage requiring investigation for detection of a possible fibroma, hyperplasia, endometriosis, or genital cancer. Once the menopause is settled a reduction in estrogen levels comes with reactive increases in FSM and LM levels, and the principal risk is the development of a cancer. The role of endogenous (obesity, diabetes, Stein-Leventhal, adenomatous hyperplasia) or exogenous (prolonged estrogen therapy alone) estrogens has to be evaluated in endometrial cancer. Cancer of the vulva also appears to be more frequent in menopausal women (natural or artificial), as well as cervical cancer and cancer of the breast. There is an apparent increase in cardiovascular risks in untreated menopausal women, but this is still discussed, as to the benefits of estrogen therapy.
Sem Hop
PMID:[Menopausal risk factors (author's transl)]. 625 25

Three hundred and thirty-three consecutive patients with adenocarcinoma of the endometrium treated from 1958 to 1978 by combined surgery and radiation therapy or radiation therapy alone were reviewed. According to the FIGO staging system, there were 204 stage I, 40 stage II, 24 stage III and 20 stage IV. 40 cases of recurrences were also included in this study. The main parameters influencing survival were clinical staging, depth of myometrial invasion, histologic differentiation as well as the possibilities of radical surgery in these patients. Analysis of therapeutic results shows the superiority of pre-operative intra-cavitary irradiation followed by total abdominal hysterectomy and bilateral salpingo-oophorectomy with an 80% actuarial survival at five years in stage I. Primary surgery followed by radiation therapy gives inferior results, particularly in stage II. Treatment by radiation therapy alone should be reserved for inoperable patients after careful evaluation and gives a 35% actuarial survival at five years. The incidence of serious therapeutic complications was 3,6 %. The early diagnosis of endometrial carcinoma by means of systematic endo-uterine explorations in post-menopausal bleeding and the elaboration of combined multi-modality protocol prior to any treatment should lead to a better cure rate for this cancer of increasing incidence.
Sem Hop 1982 Mar 04
PMID:[A study on 333 patients with adenocarcinoma of the endometrium treated by combined surgery and radiation therapy (author's transl)]. 627 42

For material reasons, mass screening for cancer of the endometrium is not feasible. The authors therefore attempt to outline the characteristics of those patients who are especially prone to develop an endometrial carcinoma. The sequence of clinical and paraclinical diagnostic procedures is recalled. Special attention is given to prophylaxis; if cancer of the endometrium is hormono-dependent, it follows that such prophylaxis is possible. In order to prevent cancer from developing, a correct balance between estrogens and progestogens must be ensured, particularly in premenopausal women. As for cancer of the cervix, correct screening and prophylaxis should result in significant improvement of the prognosis of endometrial cancer.
Sem Hop 1983 Jan 20
PMID:[Cancer of the endometrium: detection and prophylaxis]. 630 Oct 47

The epidemiologic study of 74 invasive endometrial adenocarcinomas seen over five years confirms the following well-known risk factors: early menarche, disorders of menstruation, hypofertility, and late menopause. Obesity, a positive family history and the presence of another cancer are common findings. Hormone dependent endometrial cancer provides a valuable opportunity for studying hormone and cell receptor concentrations. Hormone dependency has a practical bearing on certain preventive measures and perhaps on a new therapeutic approach to this type of cancer.
Sem Hop 1983 Nov 24
PMID:[The epidemiological study of endometrial adenocarcinoma. From 74 cases seen at the Saint-Antoine Maternity Hospital]. 632 Mar 78