Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mammaglobin B, also referred to as secretoglobin family 2A member 1 (
SCGB2A1
), has been reported to be highly expressed in uterine corpus
endometrial cancer
(UCEC) compared with in the normal endometrium. However, the prognostic value of
SCGB2A1
in UCEC remains unclear. The Oncomine, The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium databases were used to explore the differential expression of
SCGB2A1
. Furthermore, data of patients with UCEC were downloaded from TCGA, and logistic regression analysis, survival analysis, univariate and multivariate analyses, and nomogram construction were performed to identify its prognostic value in UCEC. Additionally, gene set enrichment analysis (GSEA) was utilized to estimate the mechanisms of
SCGB2A1
in UCEC. Finally, immune infiltration of
SCGB2A1
in UCEC was analyzed using the Tumor Immune Estimation Resource. Decreased mRNA and protein expression levels of
SCGB2A1
were significantly associated with poor prognostic clinicopathological characteristics (all P<0.05). Additionally, low expression levels of
SCGB2A1
were associated with decreased survival of patients with UCEC compared with high expression levels of
SCGB2A1
. Furthermore, the independent prognostic value of
SCGB2A1
in UCEC was identified by univariate and multivariate analyses. A nomogram based on 6 variables, including
SCGB2A1
expression, was developed for the estimation of the 1-, 3-, and 5-year survival probability in UCEC. Additionally, GSEA suggested that the vascular endothelial growth factor, PTEN, platelet-derived growth factor, DNA repair, KRAS signaling, and PI3K-AKT-mTOR signaling pathways were differentially enriched in the low
SCGB2A1
expression phenotype. Finally, high infiltration levels of CD8
+
T cells were associated with
SCGB2A1
in UCEC and this was associated with prognosis. The present results indicated that
SCGB2A1
may be a promising independent prognostic factor in UCEC. These signaling pathways may be crucial for the regulation of UCEC via
SCGB2A1
.
...
PMID:Mammaglobin B may be a prognostic biomarker of uterine corpus endometrial cancer. 3299 18
