Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The aim of this study was to investigate the role of
UbcH10
expression in the differential diagnosis of benign, hyperplastic, and malignant endometrial tissues and also the relationship of
UbcH10
with the clinicopathologic parameters of malignant cases. A tissue microarray was performed for 81 endometrial curettage biopsies, which histological diagnosis had demonstrated to be 13 cases of proliferative endometrium, 7 cases of disordered proliferative endometrium, 5 cases of complex atypical hyperplasia, 24 cases of nonatypical hyperplasia, and 32 cases of endometrioid adenocarcinoma. Expression of
UbcH10
was assessed by immunohistochemistry. When groups were compared according to
UbcH10
percentages and scores, a statistically significant difference was found only between the carcinoma group and the other groups, except the complex atypical hyperplasia group (P < .05). In the malignant group,
UbcH10
percentages and scores were only significantly related to age. There was no significant association between
UbcH10
expression and tumor grade and stage. Overexpression of
UbcH10
may be a useful indicator of
endometrial carcinoma
.
UbcH10
also deserves further evaluation in the detection of prognostic mean and also for its role in endometrial carcinogenesis.
...
PMID:UbcH10 expression in benign, hyperplastic, and malignant endometrial curetted materials: a tissue microarray study. 2334 73
