Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Estrogen receptor (ER) and progesterone receptor (PR) assays were performed by direct fluorescent histochemical methods in 20 endometrial carcinomas and 9 endometria of para-carcinomas. ER + and PR + were found in the patients who had not received chemotherapy and/or radiotherapies. In 4 adenosquamous carcinomas, the contents of ER and PR of adenocarcinoma components were higher than those of squamous carcinoma components. Blocking tests proved the specificity of ER and PR for estradiol and progesterone respectively. The levels of ER and PR in endometria of para-carcinomas were higher than those in carcinomas. There were higher levels of ER and PR in early clinical stage than in advanced stage, in cases free from cervical involvement than in cases cervical involvement, and in well differentiated carcinomas than in poorly differentiated carcinomas. ER and PR contents did not correlate with the depth of myometrial invasion or menopausal status. In the patient group followed up for half a year or more, 4 patients with high-level ER and PR had a good response to 17 alpha-progesterone caprate. The patients with ER + and PR + had a longer survival period than those with ER- and PR-. Our results indicated that the assay of ER and PR might be valuable for predicting the response to endocrine therapy and prognosis for patients with endometrial carcinoma.
Hua Xi Yi Ke Da Xue Xue Bao 1991 Mar
PMID:[Relation between the levels of estrogen receptor and progesterone receptor and clinicopathological status in human endometrial carcinomas]. 177 41

The objectives of this study were to investigate the causes of postmenopausal bleeding and evaluate the diagnostic value of hysterscopy. Using the diagnostic technique of hysteroscopy and directed biopsies, the authors analysed the causes of postmenopausal bleeding of 234 patients undergoing hysteroscopy. The results showed that atrophic endometrium was the most common cause of postmenopausal bleeding and that endometrial hyperplasia, endometrial carcinoma/precancerous lesion, and submucous leiomyoma/endometrial polyp were also common in the patients with postmenopausal bleeding. The agreement rate between hysteroscopy and directed biopsies was 74.61%. In 234 cases of postmenopausal bleeding, the benign and malignant pathological changes were found in 76 and 27 cases respectively. In terms of age and menopause time, there were significant differences (chi 2 = 3.36, P < 0.01; chi 2 = 3.92, P < 0.01 respectively)between the patients with postmenopausal bleeding in the benign changes group and those in the malignant changes group. So the combined use of hysteroscopical technique and directed biopsies is of great significance in finding out the causes of postmenopausal bleeding, making a definite diagnosis of endometrial carcinoma and precancerous lesion, and further preventing the occurrence of endometrial carcinoma. The examination of hysteroscopy is an effective and valuable method for diagnosing postmenopausal bleeding.
Hua Xi Yi Ke Da Xue Xue Bao 1999 Dec
PMID:[The diagnostic value of hysteroscopy on postmenopausal bleeding]. 1138 66

To make an initial inquiry into the correlation of development and prognosis with the expression of Bcl-2 protein in endometrial carcinoma, we detected the Bcl-2 protein expression in 40 normal and 60 malignant samples of the endometrium by means of an immunohistochemical technique. We observed that Bcl-2 expression varied with menstrual cycle, becoming stronger in proliferative phase and then declining in secretory phase. Bcl-2 expression in endometrial carcinoma was much weaker than that in normal endometrium, and Bcl-2 was particularly expressed in adenoacanthoma, papillary adenocarcinoma and simple adenocarcinoma. The higher grade and stage were, the stronger Bcl-2 expression was (P < 0.01). In 5 cases of endometrial carcinoma with hyperplastic endometrium, Bcl-2 expression of carcinoma was obviously weaker than that of hyperplastic endometrium. So we conclude that Bcl-2 overexpression may contribute to the formation of hyperplastic endometrium, that obvious reduction of Bcl-2 expression in endometrial carcinoma may promote apoptosis of cells, and that Bcl-2 over-expression may be associated with good prognosis.
Hua Xi Yi Ke Da Xue Xue Bao 1999 Mar
PMID:[A study of Bcl-2 expression in normal endometrium and endometrial carcinoma]. 1220 37

Expression of heat shock protein 70 (HSP70) in normal endometrium tissue and endometrial carcinoma was analyzed by the present authors to determine the relationship between HSP70 expression and the prognosis of endometrial carcinomas. The immunohistochemical reactivity of monoclonal antibodies against HSP70 was examined in 44 endometrial carcinomas and 40 normal endometria HSP70 respectively. HSP70 was expressed stronger in carcinomas than in normal. Expression of HSP70 was found in 56.82% of endometrial carcinomas and was well correlated with histological grade (P < 0.05). These results suggest that HSP70 may play a role in the prognosis of endometrial carcinomas.
Hua Xi Yi Ke Da Xue Xue Bao 1999 Sep
PMID:[Expression of heat shock protein (HSP70) in normal endometrium and endometrial carcinomas]. 1221 79

This study was conducted to immunohistochemical and biochemical measurements of estrogen receptor (ER) and progesterone receptor (PR) in endometrial carcinoma and elucidate the relationship between ER/PR contents and the clinico-pathologic features. Specific monoclonal antibodies to human ER and PR were used and the immunohistochemical (IHC) assay was performed on 36 specimens of endometrial carcinomas. Twenty-eight out of 36 specimens' ER and PR contents were also measured by dextran-coated charcoal analysis (DCC). ER and PR positive rates were 44.4% and 52.8% by IHC, and 50% and 57.1% by DCC, respectively. The two methods correlated significantly, the correlation coefficient between DCC and IHC being 0.565 for ER and 0.563 for PR (P < 0.05). ER and PR contents were much lower in grade 3 than in grades 1 and 2 endometrial carcinomas (P < 0.01). The authors conclude that the levels of ER and PR are associated with the differentiation of endometrial carcinoma. The immunohistochemical and biochemical methods correlate well. A combination of the two methods may be more useful in predicting the prognosis and choosing the treatment.
Hua Xi Yi Ke Da Xue Xue Bao 2000 Mar
PMID:[Study of estrogen and progesterone receptors in endometrial carcinoma]. 1250 28