Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Blood levels of 8-hydroxy-2'-deoxyguanosine (
8-OHdG
) were measured by enzyme immunoassay after overnight fasting in untreated breast cancer and
endometrial cancer
patients (N=170) of mainly postmenopausal age with and without type 2 diabetes mellitus. The concentrations of
8-OHdG
in patients with breast cancer were higher than in patients with
endometrial cancer
and in patients with breast cancer and diabetes in comparison with patients with breast cancer without diabetes. No correlations of blood
8-OHdG
levels with glycemia, age, and clinical stage of disease were detected. In cancer patients with diabetes, the concentration of
8-OHdG
increases proportionally to the increase in body mass index, though this does not lead to disappearance of the above differences between patients with breast cancer and
endometrial cancer
by the level of
8-OHdG
. The causes of the trend to a less favorable course of tumor process in patients with breast cancer and diabetes in comparison with
endometrial cancer
and diabetes deserve further studies.
...
PMID:Serum Levels of 8-Hydroxy-2'-Deoxyguanosine DNA in Patients with Breast Cancer and Endometrial Cancer with and without Diabetes Mellitus. 2759 Jul 67
