Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The expression of
special AT-rich sequence binding protein 1
(
SATB1
) and E-cadherin (E-cad) in tissues of patients with
endometrial carcinoma
and the relationships with clinicopathological features were investigated. One hundred and four cases of carcinoma tissues and 104 cases of para-carcinoma tissues of patients pathologically diagnosed as
endometrial carcinoma
in Affiliated Hospital of Jining Medical University (Jining, China) from August 2015 to August 2016 were selected. The expressions of
SATB1
and E-cad in tissues was detected via streptavidin peroxidase biotin (SP) immunohistochemical method, and the relationship with clinicopathological features of patients was analyzed.
SATB1
was positively expressed in 71 out of 104 cases of
endometrial carcinoma
tissues (the expression rate was 68.27%) and in 25 out of 104 cases of para-carcinoma tissues (the expression rate was 24.03%). The expression of
SATB1
in
endometrial carcinoma
tissues was significantly higher than that in para-carcinoma tissues (P<0.05). E-cad was positively expressed in 60 out of 104 cases of carcinoma tissues (the expression rate was 57.6%) and 95 out of 104 cases of para-carcinoma tissues (the positive expression rate was 91.3%) (P<0.05). The expression of
SATB1
and E-cad in
endometrial carcinoma
tissues was not associated with the menopausal status or age of patients (P>0.05), but correlated with the histological grade of
endometrial carcinoma
, depth of tumor invasion, lymph node metastasis and tumor lymph node metastasis (TNM) staging (P<0.05). In conclusion,
SATB1
and E-cad play important roles in the occurrence and development of
endometrial carcinoma
, which are of great significance to the potential therapeutic target and prognosis estimation of
endometrial carcinoma
.
...
PMID:Expression of SATB1 and E-cad in tissues of patients with endometrial carcinoma and the relationship with clinicopathological features. 2972 75
