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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four biochemical parameters, soluble oestradiol (REC) progesterone (RP) receptors, 17B oestradiol and isocitric dehydrogenase enzymes were studied to evaluate hormone sensitivity in 51 patients with endometrial carcinoma. Samples of tumours were taken before and after 7 to 14 days of oral medroxyprogesterone acetate (MPA) treatment for histological and biochemical analysis. Hormone sensitivity assessed by a decrease in receptor concentration after MPA in REC rich (p less than 0.005) and RP rich (p less than 0.02) tumours was 65% and 63% respectively. Induction of isocitric dehydrogenase enzyme with MPA was highly significant in REC rich (p less than 0.0001) and RP rich (p less than 0.001) tumours, as was the induction of 17B oestradiol dehydrogenase in REC rich (p less than 0.01) and RP rich (p less than 0.005), confirming progestogen sensitivity. Post MPA dehydrogenase enzyme levels predicted survival more accurately than pre MPA receptor status of the tumours.
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PMID:Biochemical changes in endometrial carcinoma and their correlation to clinical outcome and prognosis. 191 63

Specimens of endometrial carcinoma were obtained from 8 women, four of whom had previously been treated with oral medroxyprogesterone acetate 200 mg daily for 7 days. The activities of oestradiol-17 beta and isocitric dehydrogenases and nuclear oestradiol receptor concentrations were measured in the homogenised tissue and both enzymes were located histochemically. Histochemical evidence of oestradiol dehydrogenase activity was found in all but one of the specimens with biochemical activity. This anomalous specimen was obtained from a woman who had not been treated with MPA and whose endometrium exhibited only low levels of enzyme activity. The histochemical staining caused by isocitric dehydrogenase was intense but bore no relation to the biochemical measurement of enzyme activity in the homogenate. The modified technique for the histochemical demonstration of oestradiol dehydrogenase activity although not quantitative gave results similar to the biochemical methodology. It may therefore be useful as a simple test of the prediction of the sensitivity of endometrial carcinoma to progestogens.
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PMID:The histochemistry of oestradiol-17 beta and isocitric dehydrogenases in endometrial carcinoma. 260 29