Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Estrogen receptor-like 1a (ESRL1a; same as estrogen receptor-related orphan receptors, ERR1) belongs to a subfamily of the nuclear receptor superfamily. We have previously shown that human ESRL1a modulates estrogen responsiveness of the lactoferrin gene promoter in transiently transfected endometrial carcinoma RL95-2 cells. In this study, we cloned and characterized the human ESRL1 gene. Through the fluorescence in situ hybridization method, the ESRL1 gene was localized to the centromere region of chromosome 11q12. Partial sequencing, restriction mapping, and PCR analysis revealed that the ESRL1 gene consists of seven exons and is approximately 20 kb in length. We found that the smallest exon (exon 3) contains 117 bp and the largest exon (exon 7) has 1032 bp. The smallest intron (intron 5) is only 88 bp long and the largest intron (intron 2) is 8 kb long. All introns have the conserved GT and AG dinucleotides present at the donor and acceptor sites, respectively. Like the estrogen receptor, the highly conserved DNA-binding domain of hESRL1a is encoded by exon 2 and exon 3, and the intron/exon junctions (2 and 3) are well conserved between the two genes. Primer extension analysis revealed multiple transcription initiation start sites in human uterine (HeLa, HEC, and RL95-2) cell lines. However, one major initiation start site was found by RNase protection assay. The hESRL1a mRNA is differentially expressed in various human tissues. The nucleotide sequence adjacent to the transcription start sites of the ESRL1 lacks the typical TATA and CAAT boxes but is GC rich and contains 10 consensus Sp1-binding elements and two E boxes. The region that contains these transcription factor-binding elements showed a high level of promoter activity when transiently transfected into RL95-2 cells.
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PMID:Human estrogen receptor-like 1 (ESRL1) gene: genomic organization, chromosomal localization, and promoter characterization. 928

Estrogen receptor (ER)alpha and ERbeta mRNAs levels decreased with clinical stage, myometrial invasion and dedifferentiation. On the other hand, ERRalpha mRNA levels and histoscores increased with clinical stage and myometrial invasion, regardless of dedifferentiation. ERRalpha can bind to the steroid receptor coactivator family without any ligands, and drive transcription activity of the target genes. The competitive interaction of ERRalpha/ER expression associated with the use of common cofactors during loosing estrogen dependency might cause their expression manner. The up-regulation of ERRalpha might be related to tumor growth and advancement in uterine endometrial cancers. It is speculated that ERRalpha is a candidate for prognostic factors in uterine endometrial cancer, although ERRs are not directly related to growth of uterine endometrial cancer.
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PMID:Clinical implication of estrogen-related receptor (ERR) expression in uterine endometrial cancers. 1941 52