Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Changes in endometrial histology and cervical cytology related to use of two contraceptive implants were investigated in a 2-year prospective study conducted at Birmingham (UK) Women's Hospital. 60 women with regular menstrual cycles were randomly assigned to receive either Implanon (etonogestrel/3-keto-desogestrel) or Norplant (levonorgestrel). After 12 months of implant use, most endometrial samples in both groups were inactive or only weakly proliferative. After 24 months, this pattern remained unchanged in the Implanon group. It was more diverse, however, in the Norplant group, where there was evidence of proliferative-phase endometrium. Endometrial thickness, assessed quarterly by transvaginal ultrasound scans, was significantly reduced in users of both implants. Cervical cytology remained unchanged from baseline to 24 months. These findings suggest that users of both implant systems are not at increased risk of endometrial hyperplasia, endometrial carcinoma, cervical intra-epithelial neoplasia, or cervical carcinoma.
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PMID:A 2-year comparative study of endometrial histology and cervical cytology of contraceptive implant users in Birmingham, UK. 985 56