Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although only a small proportion of common cancers show familial aggregation, studying such families can elucidate the roles of shared environment and genes in the development of neoplasia. We report an analysis of nine colon cancer pedigrees using new nonparametric objective methods to measure familial aggregation as a means of determining the existence of heterogeneity in the data. Each family was selected through a proband with nonpolyposis colon cancer who had a first-degree relative with documented colon cancer. To assess the aggregation of different cancers in these families we employ a method which evaluates both excess number of cases as well as distribution by risk in family members. We find that eight of the nine families exhibit significant aggregation of colon cancer: endometrial cancer aggregates in three families, breast in none, kidney in one, and all sites in eight. In this way, we show that two families fit the criteria for Cancer Family Syndrome, and that one is not a high-risk cancer family.
 ...
PMID:Aggregation of colon cancer in family data. 654 32

The prognosis for women with endometrial cancer is generally good. This is because the disease is often diagnosed at an early treatable stage, as women seek care owing to postmenopausal bleeding. The prognosis is, however, worse for women with high-risk endometrial cancer. These women may benefit from more extensive surgery, including pelvic- and para-aortic lymph-node dissection, whereas such surgery is of no benefit for women with low-risk cancer. It is, therefore, important to correctly identify women with high-risk cancer before surgery. No consensus has been reached on how and when to use imaging to assess local extension of the disease. Nevertheless, evidence shows that imaging will improve the identification of women with high-risk cancer. The primary aim of this review is to present the examination technique, accuracy, imaging findings, benefits, and shortcomings of ultrasound and magnetic resonance imaging in the assessment of local tumour extension, in women with endometrial cancer. A secondary goal is to discuss the role of positron emission tomography and computed tomography, diagnostic modalities that primarily are used to detect lymph node and distant metastasis.
...
PMID:Imaging in endometrial cancer. 2485 91