Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two hundred patients at high risk for endometrial adenocarcinoma were screened using the Gravlee Jet Washer. Tissue obtained from the first 100 patients was processed by cell block technic alone; tissue from the second 100 patients was processed by cell block plus direct smear and Nucleopore filtration stained by the Papanicolaou method. All patients had histologic diagnosis by fractional curettage. Six of 12 patients with a tissue diagnosis of carcinoma were missed by the jet washer using the cell block technic alone. In the second 100 patients, no cases of cancer were missed using both cell block and cytologic technics. Technic and application of the jet washer in screening for endometrial carcinoma are discussed. We conclude that the Gravlee Jet Washer is a safe, effective screening tool which frequently may replace diagnostic curettage; however, if abnormal bleeding persists, curettage must be done.
 ...
PMID:Evaluation of the Gravlee Jet Washer using combined cell block/cytologic interpretations. 6 43

Six patients who took oral contraceptive agents for 5 to 18 years developed endometrial neoplasia. Endometrial adenocarcinoma occurred in 4 of these patients and severe adenomatous hyperplasia occured in 2. Five of the 6 patients took sequential agents; 1 patient used a combined agent. An additional patient who took Premarin and Provera sequentially developed adenocarcinoma of the endometrium. Eighteen cases of endometrial adenocarcinoma and 7 cases of adenomatous hyperplasia in patients with long-term sequential oral contraceptive use have previously been reported by others. Progestogens may not be completely protective against the endometrial cancer-causing potential of the estrogens, especially in the sequential regimens.
 ...
PMID:Endometrial carcinoma and oral contraceptive agents. 19 73

Because of the recent controversy concerning estrogen and endometrial cancer, we studied the possible potential precursor lesions of the endometrium, reviewing 263 patients hospitalized in a community teaching hospital. The estrogen hormonal status, either exogenously or endogenously produced, plays a large role in the histologic structure of the uterine endometrium and may lead to difficulty in determining the exact histologic diagnosis or its potential to progress to endometrial adenocarcinoma.
 ...
PMID:Endometrial hyperplasia: a five-year study. 22 Jul 35

Despite many years of extensive investigation, there has been neither a clear-cut pattern of hormonal production nor milieu found in women with breast cancer. Estrogen replacement therapy for menopause does not significantly increase the risk of breast cancer and one study indicated that estrogen users have a lower incidence of breast cancer than that observed in untreated women. Some studies have shown that the mortality rate from breast cancer is lower in estrogen-treated postmenopausal women. Only one investigator has found any significantly increased risk of breast cancer in oral contraceptive users. In that report, increased duration of birth control pill use decreased the risk of breast carcinoma. Several studies were unable to find an increased risk of breast cancer from oral contraceptives while one investigation observed a lower incidence in birth control pill users than that expected. The mortality from carcinoma of the breast in oral contraceptive users was lower than in non-users, most likely due to earlier detection. Although some retrospective studies have indicated that estrogen use increases the risk of endometrial cancer, a prospective investigation found only an insignificant increase. Progestogens afford some protection from cancer in estrogen-treated postmenopausal women. The incidence of endometrial adenocarcinoma is lower than that observed in untreated postmenopausal women. Combination oral contraceptives are protective against developing adenocarcinoma of the endometrium but sequential birth control pills may afford less protection.
 ...
PMID:The role of hormones in the etiology of breast and endometrial cancer. 29 15

Past studies have shown that patients with recurrent or advanced endometrial carcinoma respond favorably to treatment with progestin. Theories relate the success of the treatment to the concentration of progestin in the blood supplied to cancerous tissues. A study was undertaken to measure the plasma level of the steroid in patients with endometrial adenocarcinoma. Medroxyprogesterone Acetate (MPA) was administered to two groups of patients. One group received a single 100mg dose of MPA intramuscularly every day. The other group was subdivided and individuals received from 100 to 300mg of MPA orally everyday for a month. Plasma levels of MPA were measured daily twenty-four hours after the last dose. Radioimmunoassay techniques were used to measure MPA levels. Plasma levels of patients receiving 100 mg either orally or intramuscularly were the same. Patients who received the 200 mg and 300 mg dosage of MPA orally exhibited higher mean plasma values. Examination of cancerous tissues removed by surgery near the time of plasma MPA evaluation showed marked effects of the therapy. Two of the four patients who had the surgery had received the higher 200mg and 300mg dosage. Based on the results of this investigation, further studies on the effectiveness of treatment for recurrent or advanced endometrial adenocarcinoma should include a phase to monitor MPA plasma levels.
 ...
PMID:Plasma medroxyprogesterone acetate levels following intramuscular or oral administration in patients with endometrial adenocarcinoma. 41 65

Annual endometrial biopsy had been advocated for patients with Turner's syndrome. The practicality of using this procedure on patients with no symptoms of abnormal bleeding has been questioned; this study attempts to answer this issue. Charts of patients with Turner's syndrome from the Cleveland Clinic for the period 1951-75 were reviewed. A criteria was established for inclusion of patients in the study. 34 of 43 women who met the criteria returned for the follow-up and were given pelvic exam, Pap smear, and endometrial biopsy by Vabra aspiration. Of the 43 patients given substitution therapy, 13 were taking estrogen alone; 24 were on estrogen-progesterone therapy, and 6 had stopped taking estrogen (Table 1). The presenting symptom in all cases of endometrial adenocarcinoma was abnormal bleeding (menorrhagia or menometrorrhagia), suggesting a change from previous menstrual patterns. At high risk for developing endometrial carcinoma at an early age was patients with dysgenesis who were receiving estrogen replacement therapy. The results of this study suggest that annual endometrial sampling is not necessary for patients with Turner's syndrome. It is recommended, however, that an annual examination and a Pap smear of an endocervical specimen be performed. Should there be any sign of menstrual aberration, endometrial biopsy or dilatation and curettage should be done. The importance of careful follow-up should also be impressed on patients who are on estrogen therapy; not more than 1 year's supply of estrogen should be given to such patients.
 ...
PMID:Turner's syndrome: results of estrogen therapy. 43 70

Office endometrial biopsy with the Kevorkian curette was performed in 400 patients presenting with abnormal uterine bleeding or other endometrial cancer-risk indicators. The use of this instrument has proved to be a safe, simple, inexpensive, and highly reliable outpatient procedure with excellent patient acceptance. It has provided tissue for adequate diagnosis in 91.8% of the cases, and the diagnostic accuracy when controlled by D&C and/or total abdominal hysterectomy (TAH) was 96.2%. As a result, 73.5% of the women required no further surgical procedures for either diagnostic or therapeutic purposes. In the postmenopausal age group, adenocarcinoma was diagnosed in 7 of 177 (3.9%) women. This procedure is highly recommended for early office diagnosis of uterine pathology and, in particular, endometrial adenocarcinoma and its presumed precursor lesion, adenomatous hyperplasia.
 ...
PMID:The Kevorkian curette. An appraisal of its effectiveness in endometrial evaluation. 46 Jul 66

Three cases of clear cell carcinoma of the endometrium are here reported. Clear cell carcinoma is a rare and aggressive type of endometrial adenocarcinoma. Patients are older and are in the menopause much longer than are patients with typical endometrial carcinoma. This fact may reflect the presence of counterbalanced sex hormones in the process of carcinogenesis.
 ...
PMID:Clear cell carcinoma of endometrium. 46 71

785 women underwent the following tests to diagnose pathological intrauterine developments: hysteroscopy, radioisotopic examination of the endometrium, determination of nucleic acid levels, measurement of endometrial mitosis, the karyopycnotic index, and radioimmunological determination of serum hormone levels. In cases of endometrial cancer, an average level of P32 of 322.2% +/- 129.3% was found. Hyperplastic processes also caused an elevated P32 count, average 214% +/- 57.95%; in 9 of the 179 cases of hyperplasia, these values approached those for endometrial cancer. The RNS content is about 1.5 times greater than normal in the case of endometrial cancer, on the average 2.25 +/- .9; in cases of hyperplasia the average was 1.55. RNS was found to be 2.0-2.9 in cases of recurring hyperplasia or polyp formation. The measurement of cell mitosis was the most irregular in cases of endometrial adenocarcinoma. All patients with endometrial complaints should be examined carefully to determine the possible presence of endometrial cancer.
 ...
PMID:[Relevance of complementary methods to examine patients with intra-uterine pathological phenomena (author's transl)]. 53 24

Histological analysis of 266 hyperplastic endometria obtained by curettage revealed the following forms of hyperplasia: simplex 29.3%, cystic 50%, adenomatous 18.4, and atypical 2.2% (according to the classification accepted by the authors). Mild forms of endometrial hyperplasia (simple and cystic) recede in most cases spontaneously or after therapy and rarely turn into endometrial adenocarcinoma, whereas severe forms of hyperplasia (adenomatous and atypical), unless treated, often turn into endometrial carcinoma. The etiology, some clinical manifestations, and therapy of this condition of the endometrium are reviewed.
 ...
PMID:[Histopathological diagnosis and clinical significance of endometrial hyperplasia]. 55 15


1 2 3 4 5 6 7 8 9 10 Next >>