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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Early diagnosis of endometrial carcinoma enables one to achieve a cure rate of 80%. The purpose of this study is to characterize the patients who are prone to develop adenocarcinoma by simple epidemiologic and clinical data. The data of 109 consecutive patients who developed adenocarcinoma were compared with those of 146 control hysterectomy patients using logistic regression analysis. The following characteristics of patients who developed adenocarcinoma were identified: parity (P less than 0.0001), diabetes mellitus (P less than 0.003), hypertension (P less than 0.0001), obesity (P less than 0.0006), treatment with exogenous estrogen (P less than 0.001), and second primary tumor. The logistic regression formula classified correctly 77% of all patients to their actual group. The study showed that the relative risk of a patient to develop adenocarcinoma can be estimated from simple and readily available epidemiologic and clinical data.
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PMID:A novel approach to the analysis of risk factors in endometrial carcinoma. 398 36

The paper is concerned with some features of the dose distribution of fields of a complex shape in gamma-beam irradiation using gamma-therapeutic units and electron linear accelerators in the complex of combined radiotherapy of patients with endometrial carcinoma. The authors have performed a comparative analysis of calculated and experimental results characterizing dose fields in the utilization of individually selected forming matrices and standard splitting units. It has been shown that the utilization of the forming matrices makes it possible to optimize gamma-beam irradiation with a necessary screening of a primary tumor focus and a preset level of dose exposure in the pelvic lateral parts and zones of regional metastases. Spatial dose distribution with the help of matrices gives an opportunity to use intense intracavitary irradiation with high energy sources using an Agat-B unit.
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PMID:[Formation of dose distributions in the combined radiation treatment of patients with endometrial cancer]. 640 99

The paper is devoted to a comparative analysis of dose distributions occurring during combined radiation therapy of patients with endometrial cancer. A dosimetric analysis has shown that the level of absorbed doses in a primary tumor focus is most adequately evaluated with taking due account of dose exposures in points M but not in points A. Besides it was established that the level of radiation exposure in the irradiated organ can be changed by the individual selection of schemes for the intracavitary placement of 60Co sources of higher activity. A comparative analysis of dose distributions occurring in different methods of gamma-beam irradiation of patients was made. It has been shown that the use of the shaped fields of matrix formation provides optimum dose distribution in pathological foci and organs neighbouring with the uterus.
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PMID:[Dose distribution in combined radiotherapy of endometrial cancer using an "Agat-B" apparatus]. 673 22

The clinical characteristics of patients with second primary tumors in the ovary and endometrium were compared to those with single primary tumors treated at our Center during the same period of time. Despite the fact that the patients were under medical surveillance for the first primary tumor, most second tumors were diagnosed following patient symptoms and complaints, and not at a routine follow-up appointment. Patients with a second primary endometrial cancer had a more advanced stage of disease at diagnosis as compared to those with single endometrial cancer. This was not found to be true for patients with second ovarian cancer. Patients with primary breast cancer and colon cancer, lymphoma or melanoma were found to be at higher risk for developing a second primary tumor in the endometrium or ovary as compared to those with a primary tumor at other sites. Although there are no proven means for the early detection of these gynecologic malignancies, it seems prudent to draw the attention of medical practitioners to the need for a better gynecologic evaluation for women with cancer at other sites during their follow-up visits. Studies on the efficacy of currently available diagnostic techniques should be carried out to evaluate their yield in this high risk group.
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PMID:Clinical characteristics of patients with a second primary tumor in the endometrium or ovary. 766 66

A moderately-differentiated endometrial adenocarcinoma cell line(EI) was established from a surgical specimens obtained from a 55-year-old woman with endometrial carcinoma. This cell line could be transplanted to nude mice, where the cells showed the same histological type as the primary tumor. The doubling time of the cell line was 50.5 hours; the saturation density was 7.5 x 104 cells/cm2; the plating efficiency was 46%. This cell line was determined to produce TPA, but not other tumor markers, such as CA125 or CEA. Neither estrogen receptor, nor progesterone receptor was detected from the culture cell or the primary tumor. Chromosome analysis revealed that cells examined were all 46,XX, + 8,t(14q14q), and only cells with this karyotype were thought to be able to grow. From these results, it was suggested that a gene on No. 8 chromosome would be involved in the carcinogenesis of endometrial adenocarcinoma. Thus this cell line was thought to be useful for the clarification of gene conversion during the process of development of endometrial adenocarcinoma.
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PMID:[Establishment and characterization of the new cell line (EI) from a human endometrial adenocarcinoma]. 766 52

An estrogen (E) independent sub-clone (EIIL) was separated from a human endometrial carcinoma cell line, Ishikawa, by culturing the wild type under an E free condition for 350 days. The cells were then implanted into nude mice subcutaneously and tumors allowed to develop for 35 days. The primary lesions were then excised to stimulate recurrence. One animal developed recurrence with multiple distant metastases. The primary tumor and metastatic tumors from the animal were studied for ErbB-2 expression by immunohystochemical techniques or by a reverse transcription followed by polymerase chain reaction (RT-PCR). Expressions of epidermal growth factor (EGF) receptors, aromatase, nidogen, E receptors, hepatocyte growth factors (HGF) and beta-actin were also examined. The results showed that metastatic lesions expressed high levels of ErbB-2, nidogen and aromatase but unchanged levels of EGF receptors and HGF. The metastatic lesions expressed one third of the E receptors which were detected in the EIIL in vitro. These observations suggest that a decrease in ER along with increased expression of nidogen and aromatase is associated with the process of metastasis and the model appears to be of value in studying the process of the acquisition of a metastatic phenotype.
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PMID:[Establishment of metastatic sub-clone from estrogen independent Ishikawa cells and its characterization in vitro and in vivo]. 769 85

Two dimensional polyacrylamide gel electrophoresis of 3' end labeled total tRNA from primary and secondary (metastatic) endometrial cancer was used to obtain mapping of isoacceptors. In tRNA from primary tumor 87 isoacceptors were found whereas in metastatic cancer only 52 spots corresponding to isoacceptors were detected. Normal myometrial tRNA used as a control contained 51 isoacceptors. The isoacceptors specific for neoplasia were observed in both cancer tRNAs.
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PMID:[Transfer RNA (tRNA) in primary and metastatic endometrial cancer tissue]. 778 63

Family members from hereditary nonpolyposis colorectal cancer (HNPCC) families are at an increased risk of developing endometrial cancer. The present study was performed to investigate the epidemiology of endometrial cancer associated with HNPCC. Data on 125 cases of endometrial cancer from HNPCC families were collected from seven countries. The mean age at diagnosis was 48 years (range: 27-72 years). Fifty-seven percent of the cases were diagnosed under 50 years of age and 98 percent under 65 years. The mean ages at diagnosis of endometrial cancer were not significantly different between the countries. At the time of the investigation, 58 of the 125 cases had died (mean age at death: 59 years; range: 32-88 years). Fifteen of the 125 (12%) patients died from endometrial cancer. In 75 of the 113 (61%) endometrial cancer cases, a second primary cancer occurred. Most of these cancers (54 out of 75) were colorectal cancers. In 18 (15%) of the cases of endometrial cancers, more than two primary cancers occurred. In conclusion, endometrial cancer in HNPCC develops at a significant earlier age than in the general population. More than half of the cases had a second primary tumor. Endometrial cancer is an infrequent cause of death in the HNPCC families. A prospective study is warranted to assess the value of surveillance for endometrial cancer in these families.
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PMID:The epidemiology of endometrial cancer in hereditary nonpolyposis colorectal cancer. 797 5

The authors report two cases of surgically treated brain metastases from endometrial cancer which are quite unusual occurrences. In one of them the brain lesion was the presenting symptom of malignancy while in the other the metastasis was discovered after the primary tumor had been treated. Both the brain lesions were scarcely differentiated adenocarcinomas which closely resembled the uterine primaries histologically. The authors review the four cases reported in the literature and discuss the clinical features and the treatment of this disease. The analysis of cases shows that the metastatic potential of endometrial cancer is extremely variable and unpredictable but less severe than that observed in ovarian or cervical tumors. The authors suggest that the erratic behaviour of endometrial cancer may justify an aggressive (though necessarily palliative) approach to brain metastases even in the presence of circumscribed metastatic involvement.
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PMID:Brain metastasis from endometrial carcinoma. Report of two cases. 807 14

Umbilical metastasis from gynecologic malignancies is very rare. We report fifteen patients with primary gynecologic malignant tumors associated with umbilical metastases treated in this hospital from 1958-1991. 1, including 10 epithelial ovarian cancer. 1 malignant teratoma of the ovary, 2 endometrial carcinoma and 2 squamous cell carcinoma of the cervix. Apart from one patient initially diagnosed as stage 1 endometrial carcinoma, all patients had advanced tumors. Six patients had umbilical lesion present at the time of initial diagnosis of the primary tumor. The main clinical finding is an umbilical nodule or an ulcerated nodule in a diameter less than 2 cm. Usually the prognosis was poor. The average survival from initial diagnosis of umbilical metastasis to death was 14 months in 12 patients. There were 4 cases with longer survival, including one patient with endometrial carcinoma who survived 40 months, and 3 patients with ovarian carcinoma who survived 54, 52, 31 months, respectively. Two cases are surviving with tumor. It indicates that aggressive therapy may prolong survival time, especially in patients with ovarian cancers.
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PMID:[Umbilical metastasis from gynecologic malignancies--a clinical study of 15 cases]. 833 40


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