Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Menstrual abnormalities, such as menometrorrhagia and amenorrhea, occur with great frequency before liver transplantation due to chronic liver disease. This study of 19 patients, of whom 2 had prior hysterectomies and 6 had regular cycles, reported that only two 41 year old women still had irregular menstrual patterns after transplantation. There was no endometrial carcinoma. Thirteen had regular menstrual cycles with a median of 8 weeks afterwards, and two had a secondary amenorrhea at the ages 38 and 41. Also, two patients received cervical conization due to carcinoma, and two had healthy babies even though one had some cholestasia between the 36 and 38th weeks. Preoperative procedures included 5 curettages for menometrorrhagia, 1 prolapsis operation and tubal sterilization. The 12 patients over 45 years, of whom 1 had a hysterectomy, never regained a menstrual cycle after transplantation. Other preoperative procedures included 4 curettages for menometrorrhagia and postmenopausal blood loss, 1 cervix conization, 1 prolapsis operation, and 2 tubal sterilizations. It is suggested that contraception be used for the 1st year following transplantation, and that sterilization is not necessary when transplantation is an option; this would minimize the high rate of hysterectomy in primary biliary cirrhosis.
 ...
PMID:Normalization of menstrual pattern after liver transplantation: consequences for contraception. 228 99

Endometrial Cancer is the most frequent tumor in western world nations, with 142,000 new cases each year and 42,000 casualties. This form of cancer typically affects women between 55 and 65 years of age, and ranks fourth among female tumors. Endogenous predisposing conditions to endometrial cancer development are: late menopause, early menarche and hyperestrogenism, while hormone replacement therapy, obesity, alcohol, diabetes, and a diet rich in animal fats as well as chronic liver disease, are the exogenous factors. This tumor may also have an hereditary predisposition, as in the Lynch Syndrome or in HNPCC (Hereditary NonPolyposis Colorectal Cancer), since genetic modifications induced by the "MisMatch Repair" genes lead to a tumoral development susceptibility, not only in the colon. The phenotypical consequences of these genetic modifications may be found in the microsatellite instability (MSI) and in the loss of heterozygosity (LOH), which generate the replication errors in positive phenotypes repeats. These express the incapability to repair short nucleotide insertions or deletions, generated by a wrong DNA replication. Due to such genetic modifications, new allelic variants arise in the endometrial tissue, confirming the high degree of this genetic disorder. Recent studies showed that the MSI and LOH in endometrial cells may be associated with the possible loss in the expression of cellular control and with the possible degeneration of the cell growth phenomenon. There is also a possibility of utilizing these new genetic markers in the endometrial mucosa to study these tissues and to detect any possible neoplastic transformations, thanks to Genomics.
 ...
PMID:Microsatellite instability (MSI) as genomic markers in endometrial cancer: toward scientific evidences. 2093 28

Endometriosis, defined by the presence of viable extrauterine endometrial glands and stroma, can grow or bleed cyclically, and possesses characteristics including a destructive, invasive, and metastatic nature. Since endometriosis may result in pelvic inflammation, adhesion, chronic pain, and infertility, and can progress to biologically malignant tumors, it is a long-term major health issue in women of reproductive age. In this review, we analyze the Taiwan domestic research addressing associations between endometriosis and other diseases. Concerning malignant tumors, we identified four studies on the links between endometriosis and ovarian cancer, one on breast cancer, two on endometrial cancer, one on colorectal cancer, and one on other malignancies, as well as one on associations between endometriosis and irritable bowel syndrome, one on links with migraine headache, three on links with pelvic inflammatory diseases, four on links with infertility, four on links with obesity, four on links with chronic liver disease, four on links with rheumatoid arthritis, four on links with chronic renal disease, five on links with diabetes mellitus, and five on links with cardiovascular diseases (hypertension, hyperlipidemia, etc.). The data available to date support that women with endometriosis might be at risk of some chronic illnesses and certain malignancies, although we consider the evidence for some comorbidities to be of low quality, for example, the association between colon cancer and adenomyosis/endometriosis. We still believe that the risk of comorbidity might be higher in women with endometriosis than that we supposed before. More research is needed to determine whether women with endometriosis are really at risk of these comorbidities.
 ...
PMID:Women with endometriosis have higher comorbidities: Analysis of domestic data in Taiwan. 2755 80