Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Multicentric reticulohistiocytosis
(
MRH
) is a rare histocytic disease characterized by destructive arthritis in association with classic skin findings. Although
MRH
is not strictly a paraneoplastic disease, one quarter of cases are malignancy related. We report a case of
MRH
with an initial remission followed by an acute exacerbation several years later heralding the clinical presentation of
endometrial carcinoma
. During this flareup a skin biopsy specimen revealed a diffuse dermal infiltrate composed of histiocytes with ground-glass cytoplasm and multiple atypical mitoses. Approximately 40% of the cells stained with the proliferation marker Ki-67. Treatment of
endometrial carcinoma
resulted in improvement of skin and joint symptoms, and a repeat biopsy specimen no longer demonstrated mitotic figures. These findings support a reactive and proliferative cause of
MRH
.
...
PMID:Proliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium. 1631 73
