Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
O-glycosylation in the field of carcinogenesis has been a critical topic of concern for several decades. The abnormal function of enzymes catalyzing the first step of this process, named polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) has been determined to play an important role in cancer development and metastasis. Accordingly, we investigated the expression of
GalNAc-T6
in
endometrial carcinoma
and evaluated the relationship between invasion characteristics and the cellular level of
GalNAc-T6
. The results suggested that positive
GalNAc-T6
expression is significantly associated with histological grade of tumors and myometrial invasion characteristic. In vitro experiments showed that the over expression of
GalNAc-T6
had strong association with the decrease of endometrial cell invasiveness. Taken together, our data support the use of
GalNAc-T6
as a potential indicator of good prognosis and noninvasive tumor in patients with
endometrial carcinoma
.
...
PMID:GalNAc-T6 in the relationship with invasion ability of endometrial carcinomas and prognostic significance. 2856 66
