Gene/Protein
Disease
Symptom
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Compound
Pivot Concepts:
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Target Concepts:
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Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Although curcumin shows anti-proliferative and anti-inflammatory activities in various cancers, the effect of curcumin on cellular migration in endometrial adenocarcinoma cells remains to be understood. The current investigation was aimed to explore the anti-proliferative and anti-migratory effects of curcumin and its mechanism of action in
endometrial cancer
cells. Our in-vitro and in-vivo experimental studies showed that curcumin inhibited the proliferation of
endometrial cancer
cells and suppressed the tumor growth in Ishikawa xenograft mouse model. Curcumin induced ROS-mediated apoptosis in
endometrial cancer
cells. Curcumin suppressed the migration rate of Ishikawa and Hec-1B cells as analyzed by scratch wound assay. In transwell migration studies, knock down of
Slit-2
reversed the anti-migratory effect of curcumin in these cell lines. Curcumin significantly up-regulated the expression of
Slit-2
in Ishikawa, Hec-1B and primary
endometrial cancer
cells while it down-regulated the expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 which in turn, suppressed the expression of matrix metallopeptidases (MMP) 2 and 9, thus attenuating the migration of
endometrial cancer
cells. In summary, we have demonstrated that curcumin has inhibitory effect on cellular migration via
Slit-2
mediated down-regulation of CXCR4, SDF-1, and MMP2/MMP9 in
endometrial carcinoma
cells. These findings helped explore the role of
Slit-2
in
endometrial cancer
cells.
...
PMID:Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells. 2907 59
