Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The levels of T-system lymphocytes, macrophageal transformation of mononuclears and phagocytic activity of blood neutrophils were assayed in 194 patients with endometrial tumors, stage I-IV, (FIGO, 1988), 10-15 days after surgery, a subsequent course of telegammatherapy and 2-3 years after treatment. Ninety-seven patients of the study group were challenged by immunization with a live tularemia vaccine (LTV) 15-20 days before surgery, while the same number of controls were not. The study was randomized. Pre-operative LTV immunization showed an immunoprotective effect at all stages of combined treatment (surgery + telegammatherapy) given for endometrial carcinoma. Moreover, all said indices came back to normal in the study group 2-3 years after treatment. After surgery alone (standard uterine extirpation or with adnexa), controls with malignancies at the same stages revealed a significant decrease in the indices which fell further after radiotherapy. In the latter group, the indices came back to initial values which were below the norm.
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PMID:[Effect of live tularemia vaccine on some parameters of immune and non-specific antitumor resistance in endometrial cancer patients during combined therapy and later]. 969 81

A randomized investigation of the immediate (wound healing) and end-results (relapse and metastasis frequency, recurrence-free period, 2-, 3- or 5-year survival, lethality rate and mean lifespan) of combined (surgery + distant gamma-therapy) treatment of two groups of patients with endometrial carcinoma was carried out. The study group was operated on days 15-20 after immunization with tularemia live vaccine (TLV) while the controls were had no preliminary immunization. It was shown that all indices of the immediate and end-results of treatment were significantly better in the study group for all stages. It is concluded that TLV immunization given 15-20 days before surgery is followed by a lower frequency of postoperative complications and better end-results.
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PMID:[The effect of live tularemia vaccination on the short- and long-term results of combined therapy of patients with endometrial cancer]. 1044 40