Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As America ages the menopausal woman is emerging as a principal focus in the health care system. Research efforts continue to define the mechanism for vasomotor instability, osteoporosis, and new and improved methods of estrogen administration. Though attenuation of symptoms of hot flushes, urogenital atrophy, and prevention of osteoporosis can be accomplished by judicious estrogen replacement therapy, the attendant risk of endometrial cancer can be minimized by concurrent administration of progestogen. Gallbladder disease must be considered as an additional risk. Surveillance for early detection of breast cancer is an integral part of care for the climacteric woman. Of greatest concern and potentially greatest impact is the evolution of data endorsing estrogen replacement as a preventive measure against cardiovascular disease. With the goal of maximizing the quality of the last third of each woman's life, individual assessment of signs and symptoms of the climacteric and, if indicated, prescription for a tailored hormone replacement schedule remain the mainstay of care.
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PMID:Menopause and estrogen replacement therapy. 265 4

Obesity is associated with the development of some of the most prevalent diseases of modern society. The greatest risk is for diabetes mellitus where a body mass index above 35 kg/m2 increases the risk by 93-fold in women and by 42-fold in men. The risk of coronary heart disease is increased 86% by a 20% rise in weight in males, whereas in obese women the risk is increased 3.6-fold. Elevation of blood pressure, hyperlipidaemia and altered haemostatic factors are implicated in this high risk from coronary heart disease. Gallbladder disease is increased 2.7-fold with an enhanced cancer risk especially for colorectal cancer in males and cancer of the endometrium and biliary passages in females. Endocrine changes are associated with metabolic diseases and infertility, and respiratory problems result in sleep apnoea, hypoventilation, arrhythmias and eventual cardiac failure. Obesity is not a social stigma but an actual disease with a major genetic component to its aetiology and a financial cost estimated at $69 billion for the USA alone.
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PMID:Obesity as a disease. 924 38