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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To evaluate the clinical significance of serum SSEA-1 level, the antigen level was measured in sera of obstetric and gynecologic patients. A positive rate was low in patients with endometriosis (9.1%), myoma uteri (0%), benign ovarian tumor (15%), cervical squamous cell carcinoma (14%) and endometrial carcinoma (18%). In this series of study, interest was that positive cases in benign ovarian tumor group were all patients with dermoid cyst. On the other hand, a high positive rate was observed among the patients with cervical adenocarcinoma (50%), primary ovarian malignancies (55%) and secondary ovarian malignancies (50%). Among the patients with ovarian malignancies, serum sialyl SSEA-1 level significantly increased according to clinical stage. In patients with positive serum sialyl SSEA-1, rising or falling of the serum level of this antigen correlated well with progression or regression of the disease. Measurement of serum CA125 was also performed in patients with ovarian malignancies, which showed a significantly higher positive rate (96%) and revealed that this antigen has no correlation with sialyl SSEA-1. A low positive rate of serum sialyl SSEA-1 level (9.1%) was observed in gravidas, while a higher positive rate (43%) in puerperas, especially within three days after parturition. This evidence should be considered when serum sialyl SSEA-1 antigen is measured as tumor marker. All these observations suggest that the measurement of serum sialyl SSEA-1 level is useful not only in the diagnosis of ovarian malignancies but for the judgment of the effect of treatment and the search for their recurrences.
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PMID:[The clinical significance of serum sialyl SSEA-1 antigen in obstetrical and gynecological patients]. 197 31

Gynecologic anatomy is consistently depicted with MRI. Abnormal developmental anatomy is also well assessed. In cases of complete or partial vaginal agenesis where ultrasound is equivocal, MRI can be definitive. The various subtypes of uterine anomalies are well delineated with MRI. MRI is the optimal technique in the therapeutic evaluation of leiomyomas, because the number, size, location, and degeneration can be documented. It is particularly useful in the identification of the ovaries in the presence of an enlarged leiomyomatous uterus. Adenomyosis, an often neglected diagnosis, is distinguishable from leiomyomas. In the setting of an equivocal ultrasound, MRI is useful in discerning whether a mass is ovarian or uterine in origin. Endometriosis, a disease routinely diagnosed and staged by laparoscopy, does have a typical MR appearance and therefore can usually be differentiated from other adnexal masses. Dermoids are readily diagnosed with MRI. Other adnexal masses do not have a specific MR appearance and morphologic criteria as used with ultrasound or CT must be relied upon in suggesting whether or not the mass is benign or malignant. MRI is the procedure of choice in the staging of cervical and endometrial cancer.
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PMID:Gynecologic applications of MRI. 228 64

We conducted a study to evaluate cancer associated antigen CA-50 and CA 19-9 as tumor markers of gynecological malignancies. The positive rates of CA-50 and CA 19-9 for ovarian cancer were 35.5% and 48.8%, respectively, and thus were not very high. In terms of histological typing, relatively high positive rates were noted in mucinous type-42.9% for CA-50 and 71.4% for CA 19-9. Both antigens showed high false positive rates for benign ovarian tumors, especially for dermoid cyst, but produced few false positive cases of endometrial cyst. For cervical cancer and endometrial cancer, these antigens were positive at low rate. In conclusion, the present evaluation indicated that both CA-50 and CA 19-9 do not necessarily suffice as screening markers for gynecological malignancies; that they could potentially be of help for diagnosis of ovarian cancer of mucinous type; and that their false positive rates for endometrial cyst were very low.
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PMID:[Clinical evaluation of serum CA-50 and CA 19-9 in gynecological tumors]. 255 43

Thirty-five women were examined with female pelvic magnetic resonance imaging (MRI). 5 cases demonstrated normal pelvis structures, 3 had physiological atrophic changes, and one had an underdeveloped uterus. The other 26 cases consisted of 8 leiomyoma of uterus, 11 ovarian benign tumor, 3 ovarian cancer, 2 cervical and 2 endometrial carcinoma. Images of normal uterus as well as those pathological conditions mentioned above were depicted, and compared with the operative findings. By means of MRI, we were able to demonstrate the origin of most of the pelvic masses, number, size and location of leiomyoma, myometrial penetration, parametrial extension and lymph node metastasis of endometrial carcinoma. Cervical malignancy could be accurately staged, and serous cyst was possibly distinguished from hemorrhagic cyst. However, one case of mucinous cystadenoma was misdiagnosed as dermoid cyst; one myoma, 1 cm in diameter, in same density as the uterine muscle was overlooked and one mesonephroma of 0.3 cm in diameter situated deep in the cervical fibrous tissue was not detected.
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PMID:[Clinical application of magnetic resonance imaging in gynecology]. 275 99

To determine first, the accuracy of a gynaecological ultrasound service in the detection of four clinically significant pathologies, namely, uterine body malignancy, ovarian malignancy, ovarian dermoid cysts and other benign ovarian pathologies and second, to review the ultrasound imaging appearances of ovarian masses with histopathological correlation. Retrospective data collection from consecutive weekly multidisciplinary team meetings over a 12-month period. All patients had undergone ultrasound examination before surgery. Data included patient demographics, menopausal status, indications for ultrasound, type of practitioner carrying out the scan, operative findings and final histopathological diagnosis. Ultrasound imaging appearances were correlated to histology. Of the 47 cases of uterine malignancy, 45 had endometrial carcinoma. All had either a thickened or poorly seen or not seen endometrium. Twenty-four per cent of these women were premenopausal. Forty-seven of the 48 cases of ovarian malignancy had abnormal ultrasound findings. In six of these, the findings were of a purely cystic lesion. There were 62 cases of benign ovarian pathology (excluding dermoid cyst), all of which had an abnormal ultrasound; 16 of these had possible ultrasound features of malignancy. All 30 cases of ovarian dermoid cyst had an abnormal ultrasound with a specific diagnosis being made in 27. This study shows that ultrasound is accurate in the detection of both endometrial and ovarian disease. The endometrium that is not seen or is poorly seen is an indication for endometrial biopsy in women with postmenopausal bleeding. There is considerable overlap in the ultrasound appearances of benign and malignant ovarian lesions. Ultrasound is a good method for the accurate and specific diagnosis of an ovarian dermoid cyst.
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PMID:The ability of ultrasound to detect gynaecological neoplasms and their ultrasound morphological features. 1750 19