Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Endometrial carcinoma
(EC) is one of the most common malignancies in the world. Previous studies have investigated the altered expression of
interleukin-1 receptor-associated kinase 1
(
IRAK1
) in various cancers. We aimed at exploring the biological function and the underlying molecular mechanism of
IRAK1
in EC. In this study,
IRAK1
was found elevated in EC compared with normal tissues. Further, high
IRAK1
expression level was correlated with higher tumor stage, lymph node metastasis, myometrial invasion, and lower survival rate. Knockdown of
IRAK1
in two EC cell lines, HEC-1-B and JEC, significantly inhibited cell proliferation in vitro and in vivo. We also found that down-regulation of
IRAK1
in EC cells notably induced cell cycle arrest and apoptois, and also inhibited cell migration and invasion. Gene set enrichment analysis on The Cancer Genome Atlas dataset showed that Kyoto Encyclopedia of Genes and Genomes (KEGG) mitotic cell cycle and cell division pathways were correlative with the
IRAK1
expression, which was further confirmed in EC cells by Western blot. The expression of mitotic cell cycle (CDK1 and Cdc45) and cell division pathway (Cdc7 and MCM2) related factors was significantly suppressed by
IRAK1
knockdown. These collective data indicated that
IRAK1
overexpression promotes EC tumorigenesis by activating mitotic cell cycle and cell division pathways, and
IRAK1
may serve as a promising therapeutic strategy for EC.
...
PMID:Interleukin-1 receptor-associated kinase 1 correlates with metastasis and invasion in endometrial carcinoma. 2898 Jul 3
