Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum pregnancy zone protein (PZP) levels were determined by PZP-single radial immunodiffusion in 708 normal pregnancies, 207 pregnancies with complication, and 188 cases with gynecological tumors. The results indicated that serum PZP could be detected at the fifth week of normal pregnancy, up to peak level at the 40th week. 81.5% women with threatened abortion who had a good prognosis had normal PZP levels. The PZP levels of women with pregnancy-induced hypertension (PIH), intrauterine growth retardation (IUGR), anencephalus and ectopic pregnancy were within the normal range. However, 51.6% and 80.0% serum PZP levels in patients with malignant mole and choriocarcinoma, respectively, were below the normal level; PZP levels in cases with ovarian cancer were significantly higher than that of patients with ovarian benign tumors (P < 0.05); and PZP in endometrial carcinoma and cervical cancer were significantly higher than that in myoma of uterus (P < 0.05). This study showed that the measurement of serum PZP levels might be an important prognostic reference index for predicting the outcome of threatened abortion and identifying benign trophoblastic tumors and gynecological tumors.
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PMID:[Clinical significance in determining pregnancy zone protein]. 803 33

Serum tumor markers are useful in diagnosis and follow-up for patients with gynecological malignancy or breast cancer. In epithelial ovarian cancer, CA125 has been identified as the most sensitive marker. Unfortunately, CA125 detection in the serum of patients with minimal malignant tumor has not been possible. Many nonmalignant conditions including endometriosis, menstruation and massive ascites may elevate the CA125, and almost 50% of patients with clear cell adenocarcinoma do not show CA125 elevated above 100 U/ml. To improve sensitivity and specificity in the diagnosis of ovarian cancer, the use of multiple tumor markers and the simultaneous use of image diagnosis should be employed. The value of tumor markers in the screening for cervical cancer and endometrial cancer has received little attention. However, the utility of serum SCC as a marker for monitoring cervical squamous cell carcinoma has been established. Since hCG is produced by gestational trophoblastic neoplasia and is a sensitive marker of trophoblastic cells in the body, patients with choriocarcinoma or invasive mole must be followed closely for this parameter. The improvement of the hCG detection technique has reduced the mortality rate from trophoblastic neoplasia. In breast cancer, many markers including CEA and CA15-3 are used, and they are reported to be useful as markers for monitoring.
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PMID:[Tumor markers in gynecological and breast cancer]. 1474 42

The endometrial cavity may demonstrate various imaging manifestations such as normal, reactive, inflammatory, and benign and malignant neoplasms. We evaluated usual and unusual magnetic resonance imaging (MRI) findings of the uterine endometrial cavity, and described the diagnostic clues to differential diagnoses. Surgically proven pathologies of the uterine endometrial cavity were evaluated retrospectively with pathologic correlation. The pathologies included benign endometrial neoplasms such as endometrial hyperplasia and polyp, malignant endometrial neoplasms such as endometrial carcinoma and carcinosarcoma, endometrial-myometrial neoplasm such as endometrial stromal sarcoma, pregnancy-related lesions in the endometrial cavity such as gestational trophoblastic diseases (hydatidiform mole, invasive mole and choriocarcinoma) and placental polyp, myometrial lesions simulating endometrial lesions such as submucosal leiomyoma and some adenomyosis, endometrial neoplasms simulating myometrial lesions such as adenomyomatous polyp and endometrial lesions arising in the hemicavity of a septate/bicornate uterus, and fluid collections in the uterine cavity (hydro/hemato/pyometra). It is important to recognize various imaging findings in these diseases, in order to make a correct preoperative diagnosis.
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PMID:Pathologies of the uterine endometrial cavity: usual and unusual manifestations and pitfalls on magnetic resonance imaging. 1622 15