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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Women with uterine fibroids do not have an higher cancer risk than women without fibroids. 2. The carcinome of the breast is the most frequent cancer under autopsy cases with uterine fibroids. The carcinoma of the endometrium and of the pancreas are slightly increases, but tumours of other organs are less frequent. 3. The risk of sarcomatous degeneration of uterine fibroids is with 0,6% about fifty more less frequent then the risk of develope another cancer. 4. Hysterectomy does not diminuish the cancer risk of patients with uterine fibroids: Instead of the (not more possibles) cancers of the genital systems there develope tumours in other organs. 5. Under autopsy cases with uterins fibroids the trend to hypertonia, to adipositas, to myocardical infarction and to embollsm of the lung are slightly increased9
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PMID:[Cancer hazards in females with uterine myoma]. 56 95

There seems little question that the cause of some endometrial cancer is some carcinogenic agent that may reach the endometrial surface initially as a "chance phenomenon." About 10 years needs to elapse before the earliest morphologic change eventuates in cancer. The question is what chance does an endometrium have of developing malignant neoplasms if it is periodically shed, albeit incompletely, as in normal ovulatory cycles. The occurrence of such an event is very rare. The importance of shedding in the prevention of endometrial cancer is not a new concept. Lipsett indicates that there is a consensus that progestational stimulation of the endometrium with subsequent withdrawal bleeding protects against endometrial cancer. If periodic shedding is important in the prevention of cancer, the important question is whether young women on oral contraceptives (OCs) shed their endometrium when they are bleeding. Studies of the effects of OCs on the endometrium in the 1960s showed that the combined pills produced "marked predecidual changes" but the sequential preparations did not. Predecidual changes are required to render the endometrium deciduous. It might be predicted that the sequentials would predispose to cancer after years of use because shedding probably did not occur. The new question is whether the low dosage OCs (with probable absence of shedding) predispose young women to endometrial cancer. The use of estrogens only with postmenopausal women preserves the unshed endometrium for the requisite number of years to allow a carcinogenic agent to exert its effect.
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PMID:Prevention of endometrial cancer. 57 69

In cases of endometrial carcinoma where hysterectomy was performed, we examined histologically the marginal endometrium. For comparison we formed a control group of women of the same age. In the age between 45 and 65 adenomatous hyperplasia in the cancer group is found significantly more often. The glandular-cystic hyperplasia is found more frequently in the age group beyond 55, especially in women beyond 65. The simultaneous incidence of adenomatous hyperplasia and endometrial carcinoma suggests this form of hyperplasia being precancerous. Before the menopause the glandular-cystic hyperplasia does not seem essential for the origin of the endometrial cancer. It is not yet known why the glandular-cystic hyperplasia is found more frequently in postmenopausal women with endometrial carcinoma. The role of the estrogenic hormones as agents possibly forming a good terrain for the endometrial cancer is discussed.
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PMID:[The hyperplasia forms of the endometrium and their correlations to the endometrium carcinoma (author's transl)]. 57 87

Carcinoembryonic antigen was determined before treatment in 101 patients with adenocarcinoma of the uterus. If 2.5 ng/ml is accepted as the upper normal value, 34% of the patients with cancer of the corpus had elevated levels. Only 7% had values exceeding 5 ng/ml. The highest recorded value in endometrial carcinoma was 8.5 ng/ml. In adenocarcinoma of the cervix 68% had values over 2.5 ng/ml and a direct correlation between nodal metastases and plasma elevation of CEA was found. The highest recorded value for endocervical cancer was 108 ng/ml. No patient with localized disease had a value over 4.0 ng/ml. It is concluded that adenocarcinomas of the cervix and corpus have different biological properties, and that in adenocarcinoma of the cervix determination of CEA is a reliable indicator of the extent of disease.
Cancer 1977 Dec
PMID:Studies on carcinoembryonic antigen levels in patients with adenocarcinoma of the uterus. 58 61

A 22 year-old phenotypic female with a 45,x/46,x, r(x) mosaic complement had anovulatory cycles, histologically normal ovaries, and atypical endometrial hyperplasia which, when clinically followed by repeated biopsies, was found to progress to locally invasive endometrial carcinoma. This was successfully managed by the induction of ovulation with Clomid, which resulted in conversion of the endometrium to a normal secretory pattern for two subsequent years.
Cancer 1977 Dec
PMID:The reversible behavior of locally invasive endometrial carcinoma in a chromosomally mosaic (45,X/46,Xr(X)) young woman treated with Clomid. 58 62

Authors studied the application of vaginal hysterectomies performed on 790 patients, and abdominal hysterectomies performed on 892 patients over 15 years. The age of the patients was 41 to 60. In 233 cases the reason for the operation was a severe prolapse of the uterus in middle-aged and elderly women. 170 women underwent hysterectomy because of recidivist and persisting uterine hemorrhages. 67 elderly patients had a vaginal hysterectomy because of endometrial cancer. Vaginal hysterectomies were also performed on 58 patients with preclinical cancer of the cervix; these women were all over 40 years old. It appears that vaginal hysterectomies were mostly performed because of uterus mobility. These operations were done under lcoal infiltration anesthesia. No other operation was required for 217 patients. 237 cases necessitated plastic surgery on the vagina and on the peritoneum. 52 women had plastic surgery against frequent irretention of urine, and plastic surgery on the peritoneum. Meyo's procedure was used on 175 patients. 11 women suffered some complications after vaginal hysterectomy: severe hemorrhage, rectal injury, injury of the wall of the bladder. 15 women suffered complications after abdominal hysterectomy. It is concluded that vaginal hysterectomy is better tolerated by patients than abdominal hysterectomy. (Summary in ENG).
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PMID:[Application of vaginal hysterectomy in surgical gynecology]. 60 74

Six cases of adenocarcinoma of the endometrium associated with the Stein-Leventhal syndrome are presented. The average age of the patients was 27.8 years. All patients were treated surgically; 2 had preoperative intracavitary irradiation, and 1 had postoperative intravaginal cesium-137 application. At follow-up, ranging from 1 to 15 years, all patients are alive and free of disease. Almost 90% of endometrial adenocarcinoma in association with the Stein-Leventhal syndrome is well differentiated, and appropriate treatment is associated with a good prognosis. Conservative therapy carries the risk of progression of the cancer to more advanced stages and has very little to offer for future fertility. It is suggested that these patients be treated as are any other patients with endometrial cancer.
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PMID:Endometrial adenocarcinoma and the Stein-Leventhal syndrome. 61 43

Use of estrogen preparations among menopausal women has been causally associated with the development of hyperplasia and adenocarcinoma of the endometrium. The magnitude of the association seems to be greater for the hyperplastic and least aggressive malignant lesions, and smaller for tumors of higher stage and grade. This observed inverse relation of estrogen use to degree of malignancy is probably due to relatively early or overly liberal diagnoses of endometrial cancer among estrogen users, but could mean simply that estrogens promote less aggressive tumors. It appears the current increased incidence of endometrial cancer in the United States will not be followed by a corresponding increase in mortality from the disease.
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PMID:Noncontraceptive estrogens and abnormalities of endometrial proliferation. 62 3

A retrospective analyses of 307 cases with clinical Stage I endometrial carcinoma was done in an attempt to determine the role of radiation therapy in the optimal treatment of this disease. A review of the modern literature with over 9000 cases served as a useful tool to corroborate inferences and conclusions. The present series has 155 patients (51%) treated with preoperative megavoltage external pelvic radiation with a variation in doses of less than 6%. Five-year survival estimates (79%-83%) in clinical Stage I endometrial carcinoma are similar among the several main treatment combination that are employed; they become a useless parameter for any comparison. The pelvic failure rate constitutes a more useful guideline in assessing the most adequate therapy. The pathologic grade of the tumor is the main prognosticator in endometrial carcinoma. Intimately related to the tumor grade is the depth of myometrial invasion of the carcinoma. The size of the uterus and/or its cavity carry less prognostic significance than traditionally thought. For grade I lesions, there is little error in diagnosis, few pelvic failures and excellent survival (96%); they could be approached with initial surgery and postoperative radiation reserved for selected patients. For grade 2 tumors, the error in diagnosis and the failure rate increases with an overall survival of 87%. For grade 3 tumors, the error in diagnosis and failure rates are quite high with a 5 year survival of only 70%. Preoperative radiation, especially external beam therapy, is suggested for grades 2 and 3 Stage I tumors. The use of this treatment modality yields only 3% pelvic failure and an overall 5 year survival of almost 90%.
Cancer 1978 Mar
PMID:The management of clinical stage I endometrial carcinoma. 63 42

Of 523 patients with endometrial carcinoma, 324 were FIGO stage Ia, 85 stage Ib, 24 stage II, 44 stage III, and 46 stage IV. High-grade lesions were present in 7.1% with stage Ia, 18.8% with stage Ib, 37.5% with stage II, 29.6% with stage III, and 55.3% with stage IV. There was no significant difference from expected survival at 5, 10, and 15 years for patients with IaG1 or IbG1 disease. Patients with IaG2 and IbG2 disease showed similar survival, as did patients with IaG3 and IbG3 disease. Thus, uterine size seemed to make no difference in patient survival at comparable grades of disease. Deaths due to cancer at 5 years increased from 63% for stage Ia disease to 100% for stage IV disease. By absolute measurement of penetration, with increasing stage of disease there was greater penetration whether the disease was low or high in grade. Also, as the grade increased within a given stage, so did penetration of the myometrium.
Cancer 1978 Mar
PMID:Carcinoma of the endometrium: effect of stage and grade on survival. 63 87


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