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Query: UMLS:C0476089 (endometrial cancer)
 11,379 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper sums up studies on cytomorphologic features of endometrial carcinoma and on possibility of its cytologic diagnosis and verification of histologic forms. 83 cases are analyzed. Cytologic studies have revealed endometrial carcinoma in 70 (84.3 percent) cases. In 63 (75.9 percent) cases the histologic form of the condition was correctly identified, including 19 with differentiated adenocarcinoma, 25 with moderately-differentiated adenocarcinoma, 5 of the 7 cases with poorly-differentiated adenocarcinoma, and 4 of the 5 cases with glandular-squamous-cell carcinoma.
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PMID:[Cytologic diagnosis of adenocarcinomas and rare forms of endometrial cancer]. 170 2

In a histopathologic review of all cases of endometrial carcinoma diagnosed in Norway between 1970 and 1978, 255 cases of adenocarcinoma with squamous cell differentiation were found among the 1985 cases reviewed. One hundred eighty-one (9.1%) were adenoacanthoma and 74 (3.7%) adenosquamous carcinoma. The mean age for patients with adenoacanthoma was 57.7 years (range, 32 to 85 years) and for adenosquamous carcinoma, 62.8 years (range, 43 to 84 years). Five-year and 10-year survival rates for all patients were 83.5% and 71.8%, respectively. For patients with adenosquamous carcinoma, corresponding figures were 64.9% and 52.7%, and for those with adenoacanthoma, the figures were 91.2% and 79.6%, respectively. When stratified for grade and depth of myometrial infiltration, there was no difference in survival rates between patients with adenoacanthoma and adenosquamous carcinoma, provided hysterectomy was part of the primary treatment. In patients who had surgery, myometrial infiltration was the most important single prognostic factor. It is recommended that the terms adenoacanthoma and adenosquamous carcinoma be replaced by the descriptive term adenocarcinoma with squamous cell differentiation.
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PMID:Endometrial adenocarcinoma with squamous cell differentiation. 172 79

The advent of high-dose-rate afterloading intracavitary radiotherapy has implications for both staff safety and the possibility of convenient, outpatient-based treatment for the patient. We have carried out a retrospective analysis of its use with high-activity iridium 192 and the Buchler machine to treat the vaginal valut in patients with adenocarcinoma of the endometrium, most of whom also received external-beam radiotherapy to the pelvis. We have compared the survival, complication and local control rates with a comparable group of historical controls treated with low-dose-rate intracavitary caesium ovoids. Complication rates, which included vaginal stenosis not volunteered by the patient, were 16% (95% confidence intervals 6-26%) in the study group and 28% (95% confidence intervals 17-41%) in the control group, with no serious complications requiring surgery. The actuarial survival was 92% at 5 years in the study group, and 94% at 5 years in the control group. Local control was 94% at 5 years in the control group and 98% at 5 years in the study group. The authors suggest that the use of high-dose-rate intracavitary radiotherapy, with the Buchler afterloading system, for vaginal vault irradiation in carcinoma of the endometrium is a convenient, safe and quick method, which does not necessitate admission or sedation of the patient. In addition it provides complete radiation protection for staff.
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PMID:Treating the vaginal vault in carcinoma of the endometrium using the Buchler afterloading system. 174 86

Myometrial invasion greater than 33% negatively affects the prognosis of endometrial carcinoma. Since the endometrium is readily differentiated from myometrium via high-resolution transvaginal sonography (TVS), this prospective study was undertaken to evaluate the efficacy of TVS in determining the depth of myometrial invasion in women with endometrial adenocarcinoma. Eighteen subjects underwent TVS utilizing 5.0- and 7.5-MHz probes by a single examiner blinded to stage and grade of adenocarcinoma. Predicted TVS ratios were categorized as less than 33% or greater than or equal to 33% and compared to actual histologic invasion. Ultrasound predicted that TVS ratios greater than or equal to 33% are significantly associated with deep (greater than 33%) histologic invasion (P less than 0.01, Fisher's test). When histologic invasion was greater than or equal to 33%, TVS was 100% accurate with no false negatives. The two cases in which TVS ratios erroneously indicated invasion greater than or equal to 33% contained adenomyosis and leiomyomas. TVS is a highly accurate and convenient method for preoperatively evaluating myometrial invasion. Potentially this evaluation could influence the selection of therapy for poor-surgical-risk candidates or direct appropriate referral of patients with deeper invasion to a gynecologic oncologist.
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PMID:Endometrial carcinoma: transvaginal ultrasonography prediction of depth of myometrial invasion. 175 90

Transabdominal ultrasonic scanning was used to examine 48 patients with endometrial carcinoma; 39 of them were later operated on, and 5 of these examined in various periods after surgery. No image of the median uterine echo in women with clinical symptoms of cancer of the body of the uterus or thinning of the median structure may evidence in favor of poorly-differentiated adenocarcinoma. The authors emphasize the usefulness of echography in the diagnosis of the depth of the tumor invasion into the myometrium, detection of the recurrences, and pay special attention to imaging the uterine myoma and other associated diseases of the genitals in these patients.
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PMID:[Ultrasonic diagnosis during the treatment of patients with cancer of the uterine body]. 175 99

Estrogen receptor (ER) and progesterone receptor (PR) assays were performed by direct fluorescent histochemical methods in 20 endometrial carcinomas and 9 endometria of para-carcinomas. ER + and PR + were found in the patients who had not received chemotherapy and/or radiotherapies. In 4 adenosquamous carcinomas, the contents of ER and PR of adenocarcinoma components were higher than those of squamous carcinoma components. Blocking tests proved the specificity of ER and PR for estradiol and progesterone respectively. The levels of ER and PR in endometria of para-carcinomas were higher than those in carcinomas. There were higher levels of ER and PR in early clinical stage than in advanced stage, in cases free from cervical involvement than in cases cervical involvement, and in well differentiated carcinomas than in poorly differentiated carcinomas. ER and PR contents did not correlate with the depth of myometrial invasion or menopausal status. In the patient group followed up for half a year or more, 4 patients with high-level ER and PR had a good response to 17 alpha-progesterone caprate. The patients with ER + and PR + had a longer survival period than those with ER- and PR-. Our results indicated that the assay of ER and PR might be valuable for predicting the response to endocrine therapy and prognosis for patients with endometrial carcinoma.
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PMID:[Relation between the levels of estrogen receptor and progesterone receptor and clinicopathological status in human endometrial carcinomas]. 177 41

90 patients with endometrial carcinoma treated from 1958 to 1984 by radiotherapy alone are presented. They constituted 18.7% of all cases of endometrial carcinoma treated in the same period. According to the clinical staging system of FIGO, there were 28.89% Stage Ia, 8.89% Stage Ib, 38.89% Stage II, 20% Stage III and 3.33% Stage IV lesions. In this series, 82 patients suffered from adenocarcinoma and 8 patients from adenoacanthoma. Two treatment regimens were adopted: 1. intracavitary Ra (137Cs or 60Co) as the major form of treatment supplemented by external irradiation in 82 patients (including 5 by intracavitary 137Cs afterloading), 2. external irradiation supplemented by intracavitary Ra (or 137Cs) radiation in 8 patients. The overall 5-year survival rate was 48.89% (Stage I 58.82%, Stage II 51.42%, Stage III 33.3% and Stage IV 0%). Complications were proctitis in 17 cases hematuria in 4 and rectovaginal fistula in 1. The 5 patients treated by intracavitary afterloading radiation with high doses at reference points A and F all survived for more than 5 years. This may imply a bright future for this form of radiotherapy in the treatment of endometrial carcinoma.
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PMID:[Endometrial carcinoma treated by radiotherapy alone]. 178 52

Human papillomavirus (HPV) is associated with carcinoma of the cervix but not with carcinoma of the endometrium. HPV 16 is the type most commonly detected in squamous cell carcinomas from this site, whereas HPV 18 predominates in adenocarcinomas. We analyzed eight anal carcinomas for HPV DNA using the polymerase chain reaction and type-specific (open reading frame E6) primers for HPV 16, 18, 31, and 35. HPV DNA sequences were amplified in two of six anal adenocarcinomas and, in each case, the type was HPV 18. Sequences homologous to HPV 16 were amplified in each of two anal squamous cell carcinomas; one also contained HPV 18. No amplification was detected in any of seven adenocarcinomas of the rectum or colon or in three adenomatous polyps of the colon. It is concluded that HPV is associated with anal adenocarcinomas but not colorectal adenocarcinomas. The reason(s) why HPV is associated with adenocarcinoma of the anus and cervix but not with the rectum and endometrium, despite the close proximity, requires further study.
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PMID:Human papillomavirus detection in adenocarcinoma of the anus. 185 May 18

Endometrial carcinoma is the most common gynaecological invasive cancer. Since its incidence is increasing, more patients will develop recurrent disease. In an attempt to identify possible prognostic factors associated with survival, we reviewed the results of 45 patients treated in our department for recurrent clinical stage I endometrial carcinoma. All patients received primary therapy consisting of surgical resection. 16 patients developed recurrent disease after initial operative treatment and adjuvant radiotherapy. The minimum follow-up of 3 years was available in 43 patients and the actual 3-year survival rate was estimated 42% (median 16 months). Significant prognostic factors were recurrence site--vagina, 51% (17/33 pts) vs extravaginal, 20% (2/10 pts) (p = 0.01), and histological cell type--non-papillary carcinoma, 50% (17/34 pts) vs papillary adenocarcinoma, 22% (2/9 pts) (p = 0.02). Late recurrences have been reported to carry a better prognosis, than those that recur early. In the present study, time of onset did not appear to be a significant factor--recurrence occurs within 24 months, 36% (9/25 pts) vs recurrence appearing after 2 years, 55% (10/18 pts). We suggest, that systemic therapy should be prospectively evaluated in high-risk patients. Selected patients with recurrent disease--cases of non-papillary histological cell type and vaginal recurrence--can be cured by radiotherapy.
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PMID:[Recurrence of stage I endometrial cancer: effect of prognostic factors on therapeutic results]. 186 Jun 59

1. The specific bindings of estriol (E3) and estradiol-17 beta (E2) to their specific receptors were investigated in endometrial carcinoma from 7 patients and normal tissues from their respective organs or from other patients. 2. In both cytosolic and KCl-extracted fractions from them, specific binding sites for E3 and E2 were detected, demonstrating the presence of their separate receptors in human uterus-associated tissues. 3. In certain cases (6 cases) of well-differentiated adenocarcinoma, the ratio of concentration of E3 receptor to that of E2 receptor was almost equal to or higher than in other normal tissues. 4. These findings of unique localization of E3 receptor distribution may offer new insight into identification of endometrial carcinoma more likely to respond to hormonal influence or therapy.
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PMID:Estriol binding in uterine corpus cancer and in normal uterine tissues. 186 22


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