Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0476089 (
endometrial cancer
)
11,379
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This study aimed to investigate the expression of
Friend leukemia virus integration 1
(
Fli-1
) and its correlation with the prognosis of
endometrial cancer
(EC). Thirty-two EC tissue samples were evaluated for
Fli-1
expression using immunohistochemistry.
Fli-1
showed significantly high expression in EC cells, followed by hyperplasia cells, and was negative in adjacent normal tissues. The high expression of
Fli-1
was significantly associated with a high differentiation grade, mutated P53 expression, and histological subtype (p < .05). Downregulation of
Fli-1
in AN3CN cells using RNA interference inhibited cell clone formation and proliferation but did not affect apoptosis and migration of the cells. This study provides the first evidence that
Fli-1
expression gradually increases in parallel with disease progression, and its overexpression might predict poor prognosis in EC.
...
PMID:Overexpression of Fli-1 is associated with adverse prognosis of endometrial cancer. 2630 2
