Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0451641 (urolithiasis)
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Human Gene/Protein
Lon protease homolog 11.4
sulfate anion transporter 11.2
CFEX 10.3
SLC7A9 9.9
alanine-glyoxylate aminotransferase 9.9
SLC3A1 9.9
SLC22A12 9.8
HMCS 9.8
AGXT 9.6
HCNP 9.4
NCCT 9.3
GRHPR 9.2
GLA domain 9.2
SAT-1 9.1
SLC26A6 9.0
Alanine:glyoxylate aminotransferase 9.0
SLC17A3 9.0
HM4 8.7
NPT2 8.6
PH1 8.6
ZNF365 8.6
molybdenum cofactor sulfurase 8.6
DJS 8.5
aldehyde oxidase 1 8.3
Wermer syndrome 8.2
SLC34A1 8.2
DTDST 8.1
alanine:glyoxylate aminotransferase 8.1
urate transporter 1 8.1
serine:pyruvate aminotransferase 8.1
SLC2A9 8.0
CLDN19 8.0
Interleukin 17A 7.8
RST 7.8
XDH 7.8
claudin-14 7.8
carbonate dehydratase 7.8
DGKH 7.7
epithelial calcium channel 7.6
HPTP 7.4
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Disease
Complex ovarian cyst 13.0
Postoperative septic shock 13.0
Chronic urate nephropathy 13.0
urolithiasis 13.0
Familial renal hypouricemia 12.4
APRT*J 12.4
Feline lower urinary tract disease 12.0
APRT deficiency 11.6
Visceral gout 11.6
Xanthinuria 11.5
Kelley-Seegmiller syndrome 11.4
Hyperoxalemia 11.4
Xanthine oxidase deficiency 11.2
Secondary oxalosis 11.1
Drug-induced sexual dysfunction 11.0
urethrolithiasis 11.0
hyperoxaluria 10.8
EPO resistant anemia 10.6
Enteric hyperoxaluria 10.6
Medullary nephrocalcinosis 10.5
Idiopathic hypercalciuria 10.5
hydrocalycosis 10.4
gouty nephropathy 10.2
purine metabolism disorder 10.2
cystinuria 10.0
Toxic nephropathy 10.0
ureterolithiasis 10.0
hypercalciuria 9.8
primary hyperoxaluria 9.7
Uric acid nephrolithiasis 9.6
cystopyelitis 9.4
Distal RTA 9.4
epicondylitis of the elbow 9.4
nephrolithiasis 9.3
urinary tract neoplasm 9.3
Urinary stasis 9.3
Indeterminate colitis 9.2
VDD1 9.2
oxalosis 9.1
nephrocalcinosis 9.1
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Symptom
urethralgia 11.4
strangury 9.9
renal colic 9.8
Prostatodynia 9.1
Dribbling 8.7
dysorexia 8.6
urological problem 8.1
left lower quadrant pain 8.1
flank pain 8.0
renal pain 7.9
hyperosmia 7.8
phosphatemia 7.2
dysuria 7.0
Acute urinary retention 7.0
pneumaturia 6.8
Urinary symptoms 6.7
loin pain 6.6
colic 6.6
frequent urination 6.6
urinary frequency 6.4
pedal edema 6.2
Macula 6.1
right lower quadrant pain 5.7
enuresis 5.3
oliguria 5.1
tenesmus 5.1
body pain 4.9
acute low back pain 4.9
prostatism 4.8
polyuria 4.7
No adverse effect 4.6
bladder pain 4.4
polydipsia 4.2
heel pain 4.1
stomach pain 4.0
abdominal pain 3.9
emaciation 3.9
hyperesthesia 3.9
acute abdominal pain 3.6
thigh pain 3.6
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Drug
Urocalun 12.0
Potassium citrate 10.3
Sodium copper chlorophyllin 10.2
Muraglitazar 9.9
Potassium bicarbonate 9.6
Tiopronin 8.9
Colestid 8.8
Bendrofluazide 8.6
Silodosin 8.3
Atazanavir sulfate 8.2
Moco 8.1
Crixivan 7.7
Magnesium stearate 7.3
Barium sulfate 7.2
Magnesium chloride 7.1
Colestipol 6.9
Timentin 6.8
CPFX 6.8
Ammonium chloride 6.7
Indinavir 6.6
Deuterium oxide 6.5
URF 6.4
Sodium thiosulfate 6.4
CG1 6.3
Safflower 6.0
Chlorothiazide 5.9
Hydrochlorothiazide 5.9
Pyridoxal phosphate 5.8
Febuxostat 5.8
ATV 5.4
Zonisamide 5.4
Deferasirox 5.4
Bactrim 5.3
Urokinase 5.3
Iohexol 5.0
Rasburicase 5.0
EMB 4.9
Vitamin B 4.7
Piracetam 4.5
DMSA 4.4
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Enzyme
oxalyl-CoA decarboxylase 10.9
formyl-CoA transferase 9.7
PNL 9.3
adenine phosphoribosyltransferase 9.2
AGT 7.3
oxalate decarboxylase 7.2
glyoxylate reductase 6.7
oxalate oxidase 6.7
glyoxylate reductase 6.7
5-oxoprolinase 6.5
xanthine dehydrogenase 6.2
urease 6.0
urease 5.9
hydroxypyruvate reductase 5.5
adenylosuccinate lyase 5.4
hydroxypyruvate reductase 5.4
sulfite oxidase 5.2
sulfite oxidase 5.1
uricase 5.1
PRPP synthetase 5.0
aldehyde oxidase 5.0
PHT 5.0
SPT 4.9
proteinase-3 4.6
glycolate oxidase 4.5
dextranase 4.3
IscS 4.2
SPT 4.2
xanthine oxidase 4.0
dihydropteroate synthase 3.9
cysteine synthase 3.7
hypoxanthine-guanine phosphoribosyltransferase 3.7
glutathione synthetase 3.6
transhydrogenase 3.5
DTA 3.2
carbonic anhydrase 3.1
diacylglycerol kinase 3.0
calcium pump 3.0
nucleotidase 3.0
5alpha-reductase 2.9
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Compound
Indinavir sulfate 11.2
Schaftoside 10.2
dimethyloctanoate 9.8
oxalate 9.4
Visnagin 9.3
Ethyl gallate 9.3
Trichlormethiazide 8.8
Taraxasterol 8.6
8-azaspiro[4.5]decane-7,9-dione 8.4
ONB 8.1
Tamsulosin 8.0
Cystine 7.9
Xanthine 7.7
Uric acid 7.6
HM-3 7.5
hydroxyacetic acid 7.4
OH-M 7.4
Sulfisoxazole 7.3
Cystine 7.3
Thiazide 7.1
Sodium cyanide 7.1
oxalic acid 7.1
Bergenin 7.1
Melamine 7.0
Colestipol 6.9
Lupeol 6.7
Indinavir 6.6
Molybdenum cofactor 6.6
Diosmin 6.5
Terazosin 6.4
Pyridoxine 6.4
HPP 6.4
Zonisamide 6.3
oxalic acid 6.3
FUR 6.2
Triamterene 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
more...