Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0451641 (urolithiasis)
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Human Gene/Protein
Lon protease homolog 11.4
sulfate anion transporter 11.2
CFEX 10.3
alanine-glyoxylate aminotransferase 9.9
SLC7A9 9.9
SLC3A1 9.9
SLC22A12 9.8
HMCS 9.8
AGXT 9.6
HCNP 9.4
NCCT 9.3
GRHPR 9.2
GLA domain 9.2
SAT-1 9.1
SLC26A6 9.0
SLC17A3 9.0
Alanine:glyoxylate aminotransferase 9.0
HM4 8.7
NPT2 8.6
PH1 8.6
ZNF365 8.6
molybdenum cofactor sulfurase 8.6
DJS 8.5
aldehyde oxidase 1 8.3
Wermer syndrome 8.2
SLC34A1 8.2
DTDST 8.1
urate transporter 1 8.1
alanine:glyoxylate aminotransferase 8.1
serine:pyruvate aminotransferase 8.1
SLC2A9 8.0
CLDN19 8.0
Interleukin 17A 7.8
RST 7.8
XDH 7.8
claudin-14 7.8
carbonate dehydratase 7.8
DGKH 7.7
epithelial calcium channel 7.6
HPTP 7.4
Glycolate oxidase 7.4
TRPV5 7.4
Tamm-Horsfall glycoprotein 7.4
HM3 7.4
PRPS1 7.3
SLC34A3 7.3
GLUT9 7.3
bikunin 7.3
CLCN5 7.2
CDC73 7.2
inter-alpha 7.2
uropontin 7.1
rBAT 7.1
uromodulin 7.0
NaSi-1 7.0
CG2 6.9
Inorganic pyrophosphatase 6.9
VDDR 6.9
5-oxoprolinase 6.8
MASCOT 6.7
MEPE 6.6
gamma-glutamyl carboxylase 6.6
McKusick-Kaufman syndrome 6.6
parafibromin 6.6
xanthine dehydrogenase 6.6
CLC-5 6.5
OC3 6.5
CG1 6.4
SLK 6.4
Claudin-16 6.4
ileal bile acid binding protein 6.4
GOX 6.4
PTF1 6.4
Hb1 6.4
forkhead box L2 6.4
HPT 6.3
PH2 6.3
GALNS 6.2
HSPG2 6.2
anion transporter 6.2
UTI 6.2
AGT 6.1
OPN 6.1
hydroxypyruvate reductase 6.1
uroplakin III 6.1
CNM 6.1
SLC26A3 6.1
calgranulin C 6.1
OCRL1 6.0
osteopontin 6.0
Fez 6.0
TWINKLE 6.0
CYBA 6.0
A transferase 6.0
FHH 6.0
SEPT9 5.9
interleukin 18 5.9
CYP24A1 5.8
PAT1 5.8
nicotinamide nucleotide transhydrogenase 5.8
RTA 5.8
AO2 5.8
PH3 5.7
secreted phosphoprotein 1 5.7
SLC4A1 5.7
cytochrome B 5.7
vitamin K epoxide reductase 5.7
HSPG 5.7
HIRA 5.6
NHERF1 5.6
ATP-dependent RNA helicase 5.6
ZES 5.5
fetuin-A 5.5
NHERF2 5.5
PDZK1 5.5
HUC 5.4
MPL 5.4
Che-1 5.4
Gc-globulin 5.4
Spp1 5.3
protein Z 5.3
NRK 5.3
4F) 5.3
HLA-B35 5.3
anion exchanger 5.3
5' nucleotidase 5.2
sulfite oxidase 5.2
ABCC4 5.1
ENDO 5.1
tight junction protein ZO-1 5.1
PKD2 5.1
S100A9 5.1
NADPH oxidase 1 5.1
AMPS 5.0
A30 5.0
Vitamin D receptor 5.0
BBS 5.0
EBP50 5.0
EMB 5.0
lactotransferrin 5.0
Parathyroid hormone 4.9
ATP binding cassette transporter 4.9
aldehyde oxidase 4.9
SPT 4.9
RSS 4.9
vitamin D receptor 4.9
cysteine desulfurase 4.9
PHEX 4.9
calcium sensing receptor 4.8
parathyroid hormone 4.8
dach 4.8
aquaporin 2 4.8
S100A8 4.7
ALPL 4.7
parathormone 4.7
CAII 4.7
chronic renal failure 4.7
glycolate oxidase 4.6
OAT3 4.6
Period 1 4.6
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Disease
Complex ovarian cyst 13.0
Chronic urate nephropathy 13.0
urolithiasis 13.0
Postoperative septic shock 13.0
Familial renal hypouricemia 12.4
APRT*J 12.4
Feline lower urinary tract disease 12.0
APRT deficiency 11.6
Visceral gout 11.6
Xanthinuria 11.5
Hyperoxalemia 11.4
Kelley-Seegmiller syndrome 11.4
Xanthine oxidase deficiency 11.2
Secondary oxalosis 11.1
urethrolithiasis 11.0
Drug-induced sexual dysfunction 11.0
hyperoxaluria 10.8
Enteric hyperoxaluria 10.6
EPO resistant anemia 10.6
Medullary nephrocalcinosis 10.5
Idiopathic hypercalciuria 10.5
hydrocalycosis 10.4
gouty nephropathy 10.2
purine metabolism disorder 10.2
cystinuria 10.0
Toxic nephropathy 10.0
ureterolithiasis 10.0
hypercalciuria 9.8
primary hyperoxaluria 9.7
Uric acid nephrolithiasis 9.6
cystopyelitis 9.4
Distal RTA 9.4
epicondylitis of the elbow 9.4
nephrolithiasis 9.3
Urinary stasis 9.3
urinary tract neoplasm 9.3
VDD1 9.2
Indeterminate colitis 9.2
oxalosis 9.1
nephrocalcinosis 9.1
Ureter 9.0
Ureter 9.0
sponge kidney 9.0
pyonephrosis 8.9
cavernositis 8.8
Appendiceal mucocele 8.8
nephroptosis 8.7
staghorn calculus 8.7
demineralization of bone 8.6
Parathyroid adenoma 8.6
Urogenital tuberculosis 8.5
chronic cystitis 8.5
Malignant neoplasm 8.4
Bilateral hydronephrosis 8.4
Xanthogranulomatous pyelonephritis 8.3
Distal renal tubular acidosis 8.3
Dent's disease 8.3
Renal pelvis 8.2
Renal pelvis 8.2
uricosuria 8.1
podagra 8.1
urosepsis 8.0
chronic urinary tract infection 7.9
Gouty arthritis 7.9
Bladder outlet obstruction 7.8
Mucinous cystadenoma 7.8
pyelitis 7.8
uropathy 7.8
Obstructive nephropathy 7.8
BBS6 7.8
urinary system cancer 7.8
pyuria 7.7
hydronephrosis 7.6
hypophosphaturia 7.6
Acute renal insufficiency 7.6
MKKS 7.6
pyelonephritis 7.6
bladder neoplasm 7.6
Azotemia 7.5
tophi 7.5
Renal infarction 7.4
Nephrogenic adenoma 7.4
phosphaturia 7.4
urinary tract obstruction 7.4
recurrent urinary tract infection 7.3
laxative abuse 7.3
ureter 7.3
Parathyroid gland 7.2
Parathyroid gland 7.2
Parathyroid gland 7.2
Ureteropelvic junction obstruction 7.2
Hunner 7.2
renal tubular acidosis 7.2
urethral prolapse 7.1
Calcium deficiency 7.1
Renal scarring 7.1
hyperuricemia 7.1
urinary tract infection 7.0
primary hyperparathyroidism 7.0
Severe depression 6.9
balanoposthitis 6.9
Severe malnutrition 6.9
anuria 6.8
varicose ulcer 6.8
gout 6.8
Ureteral obstruction 6.7
vitamin B6 deficiency 6.7
ureteritis 6.7
prostatic adenoma 6.7
Cystadenomas 6.6
squamous cell carcinoma of the bladder 6.6
Emphysematous pyelonephritis 6.6
solvent abuse 6.5
Fitz-Hugh-Curtis syndrome 6.4
hydroureteronephrosis 6.4
chondrodystrophy 6.4
azotemia 6.3
Penis 6.3
Inborn errors of metabolism 6.3
carbuncle 6.3
Acute pyelonephritis 6.3
leukoerythroblastosis 6.3
sprue 6.2
Bladder 6.2
Bladder 6.2
Bladder 6.2
metabolic syndrome X 6.1
Parathyroid carcinoma 6.1
HRPT2 6.1
VATER association 6.1
cystitis 6.1
Lesch-Nyhan syndrome 6.1
HP1 6.0
Autonomic dysreflexia 6.0
Penis 6.0
Metabolic bone disease 6.0
acute gastritis 5.9
endomyometritis 5.9
bacteriuria 5.8
Prostatitis 5.8
small bowel adenocarcinoma 5.8
interstitial cystitis 5.8
SFS 5.8
lupoid 5.8
Bellini duct carcinoma 5.7
pelvic cancer 5.7
metabolic disorder 5.7
hypercalcemia 5.7
enzyme deficiency 5.7
prostatitis 5.7
interstitial nephritis 5.7
NPHP1 5.7
Proteus 5.7
salivary gland cancer 5.7
bladder neck obstruction 5.7
ISD 5.6
tubulovillous adenoma 5.6
Rasmussen encephalitis 5.6
urethra 5.6
psychogenic impotence 5.6
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Symptom
urethralgia 11.4
strangury 9.9
renal colic 9.8
Prostatodynia 9.1
Dribbling 8.7
dysorexia 8.6
urological problem 8.1
left lower quadrant pain 8.1
flank pain 8.0
renal pain 7.9
hyperosmia 7.8
phosphatemia 7.2
dysuria 7.0
Acute urinary retention 7.0
pneumaturia 6.8
Urinary symptoms 6.7
loin pain 6.6
colic 6.6
frequent urination 6.6
urinary frequency 6.4
pedal edema 6.2
Macula 6.1
right lower quadrant pain 5.7
enuresis 5.3
oliguria 5.1
tenesmus 5.1
body pain 4.9
acute low back pain 4.9
prostatism 4.8
polyuria 4.7
No adverse effect 4.6
bladder pain 4.4
polydipsia 4.2
heel pain 4.1
stomach pain 4.0
abdominal pain 3.9
emaciation 3.9
hyperesthesia 3.9
acute abdominal pain 3.6
thigh pain 3.6
lethargy 3.5
rigors 3.3
livedo 3.2
hip pain 3.2
overweight 3.1
constipation 3.1
back pain 3.1
pelvic pain 3.0
acute abdomen 3.0
analgesia 2.9
microbial colonization 2.9
Postoperative pain 2.9
productive cough 2.8
dental pain 2.7
muscle stiffness 2.7
hypertonia 2.7
anorexia 2.7
vomiting 2.7
flushing 2.6
chronic constipation 2.6
anesthesia 2.5
cachexia 2.5
bone pain 2.4
low back pain 2.3
pain 2.3
epigastric pain 2.2
abdominal discomfort 2.2
agitation 2.0
twitching 2.0
fever of unknown origin 1.9
thinning 1.8
spasm 1.7
pallor 1.7
nausea 1.6
diarrhea 1.5
shoulder pain 1.5
hepatomegaly 1.5
acidity 1.4
nausea and vomiting 1.3
dizziness 1.3
vertigo 1.2
arthralgia 1.2
cyanosis 1.1
acute pain 1.0
chills 0.9
discomfort 0.8
acute stress 0.8
syncope 0.8
fatigue 0.8
cough 0.7
discomfort 0.7
numbness 0.6
shortness of breath 0.6
ataxia 0.6
paresis 0.5
hypotonia 0.5
hemoptysis 0.4
spasticity 0.3
tinnitus 0.3
exhaustion 0.2
angina 0.2
hypothermia -0.1
seizures -0.2
dyspnea -0.2
headache -0.2
Ill -0.5
weakness -0.7
erythema -0.7
collapse -0.8
respiratory distress -1.3
Drug
Urocalun 12.0
Potassium citrate 10.3
Sodium copper chlorophyllin 10.2
Muraglitazar 9.9
Potassium bicarbonate 9.6
Tiopronin 8.9
Colestid 8.8
Bendrofluazide 8.6
Silodosin 8.3
Atazanavir sulfate 8.2
Moco 8.1
Crixivan 7.7
Magnesium stearate 7.3
Barium sulfate 7.2
Magnesium chloride 7.1
Colestipol 6.9
Timentin 6.8
CPFX 6.8
Ammonium chloride 6.7
Indinavir 6.6
Deuterium oxide 6.5
URF 6.4
Sodium thiosulfate 6.4
CG1 6.3
Safflower 6.0
Chlorothiazide 5.9
Hydrochlorothiazide 5.9
Pyridoxal phosphate 5.8
Febuxostat 5.8
ATV 5.4
Zonisamide 5.4
Deferasirox 5.4
Bactrim 5.3
Urokinase 5.3
Rasburicase 5.0
Iohexol 5.0
EMB 4.9
Vitamin B 4.7
Piracetam 4.5
DMSA 4.4
SPP 4.4
Trimethoprim-sulfamethoxazole 4.4
Doyle 4.3
PTH 3.9
Meropenem 3.8
Silica 3.7
Glide 3.7
Meropenem 3.7
Tocopherol 3.5
uPA 3.5
Carotenoid 3.5
ROC 3.4
CIA 3.4
Android 3.3
Ofloxacin 3.3
Xanthium 3.3
citric acid 3.2
APD 3.2
Gastro 3.1
Amoxicillin 3.1
Nephron 3.1
NAG 2.9
Hypaque 2.9
Infliximab 2.8
Infliximab 2.8
Albumin 2.7
Nephron 2.7
Methylene blue 2.6
CCL 2.6
Fluconazole 2.6
NBT 2.6
IL-1ra 2.5
Vitamin A 2.4
ascorbate 2.4
Coral 2.4
vitamin E 2.3
Fructose 2.1
Bifidobacterium 2.0
CaCl2 1.9
CaCl2 1.9
CaCl2 1.9
Estrogens 1.8
CDP 1.8
pyridoxal phosphate 1.7
Alanine 1.5
ampicillin 1.3
Dial 1.1
Spectrum 1.0
lysine 0.7
Angiotensin II 0.7
Glutathione 0.6
ICI 0.6
SiO2 0.4
Mutagen 0.4
ROS 0.3
caffeine 0.2
Spectrum 0.0
Monit -0.1
Leaf -0.4
MAP -1.0
CSF -2.0
Dermatol -4.0
Cardiovasc -4.6
Enzyme
oxalyl-CoA decarboxylase 10.9
formyl-CoA transferase 9.7
PNL 9.3
adenine phosphoribosyltransferase 9.2
AGT 7.3
oxalate decarboxylase 7.2
glyoxylate reductase 6.7
oxalate oxidase 6.7
glyoxylate reductase 6.7
5-oxoprolinase 6.5
xanthine dehydrogenase 6.2
urease 6.0
urease 5.9
hydroxypyruvate reductase 5.5
adenylosuccinate lyase 5.4
hydroxypyruvate reductase 5.4
sulfite oxidase 5.2
sulfite oxidase 5.1
uricase 5.1
PRPP synthetase 5.0
aldehyde oxidase 5.0
PHT 5.0
SPT 4.9
proteinase-3 4.6
glycolate oxidase 4.5
dextranase 4.3
IscS 4.2
SPT 4.2
xanthine oxidase 4.0
dihydropteroate synthase 3.9
cysteine synthase 3.7
hypoxanthine-guanine phosphoribosyltransferase 3.7
glutathione synthetase 3.6
transhydrogenase 3.5
DTA 3.2
carbonic anhydrase 3.1
diacylglycerol kinase 3.0
calcium pump 3.0
nucleotidase 3.0
5alpha-reductase 2.9
5alpha-reductase 2.9
PCE 2.6
sialidase 2.6
purine nucleoside phosphorylase 2.5
urokinase-type plasminogen activator 2.4
alkaline phosphatase 2.3
paraoxonase 2.2
aldehyde dehydrogenase 2.2
cathepsin G 2.2
botulinum neurotoxin 2.1
chondroitinase 2.0
NADPH oxidase 2.0
lactate dehydrogenase 1.8
NADPH oxidase 1.8
ceruloplasmin 1.7
MDP 1.6
superoxide dismutase 1.4
isocitrate dehydrogenase 1.4
isocitrate dehydrogenase 1.2
prostate-specific antigen 1.2
caspase-9 1.1
beta-glucuronidase 1.1
lysozyme 0.9
glutathione peroxidase 0.9
gamma-glutamyl transpeptidase 0.8
transglutaminase 0.7
adenosine deaminase 0.6
adenosine deaminase 0.6
alanine aminotransferase 0.6
catalase 0.5
kallikrein 0.4
ACE 0.4
NQO1 0.4
phosphodiesterase 0.4
caspase-1 0.4
creatine kinase 0.3
ornithine decarboxylase 0.3
acid phosphatase 0.3
renin 0.2
neuraminidase 0.2
MAP 0.1
glucose-6-phosphate dehydrogenase 0.0
thrombin -0.1
calcineurin -0.1
transcriptase -0.2
glutathione reductase -0.2
CD10 -0.3
reverse transcriptase -0.4
aspartate aminotransferase -0.4
chymotrypsin -0.4
cholinesterase -0.7
ATPase -0.7
P-glycoprotein -0.7
beta-lactamase -0.7
acetylcholinesterase -0.8
beta-galactosidase -0.9
RNase -1.0
caspase-3 -1.2
RNase -1.2
phospholipase C -1.2
endonuclease -1.2
lipase -1.2
luciferase -1.3
mitogen-activated protein kinase -1.3
trypsin -1.4
peroxidase -1.4
focal adhesion kinase -1.5
RNA polymerase -2.1
ERK -2.6
protein kinase C -2.6
Compound
Indinavir sulfate 11.2
Schaftoside 10.2
dimethyloctanoate 9.8
oxalate 9.4
Visnagin 9.3
Ethyl gallate 9.3
Trichlormethiazide 8.8
Taraxasterol 8.6
8-azaspiro[4.5]decane-7,9-dione 8.4
ONB 8.1
Tamsulosin 8.0
Cystine 7.9
Xanthine 7.7
Uric acid 7.6
HM-3 7.5
OH-M 7.4
hydroxyacetic acid 7.4
Sulfisoxazole 7.3
Cystine 7.3
Thiazide 7.1
Sodium cyanide 7.1
oxalic acid 7.1
Bergenin 7.1
Melamine 7.0
Colestipol 6.9
Lupeol 6.7
Indinavir 6.6
Molybdenum cofactor 6.6
Diosmin 6.5
Terazosin 6.4
Pyridoxine 6.4
HPP 6.4
Zonisamide 6.3
oxalic acid 6.3
FUR 6.2
Triamterene 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
oxalic acid 6.2
Glycolate 6.1
Retigabine 6.0
Ceftizoxime 6.0
HPT 5.9
PH2 5.7
SDA 5.6
EDAP 5.5
acetohydrazide 5.4
5-oxoproline 5.4
5-oxoproline 5.4
Prone 5.4
CIT 5.3
2-aminobenzamide 5.3
Hydrochlorothiazide 5.2
Glyoxylate 5.2
5-oxoproline 5.2
Chenodeoxycholic acid 5.2
CCC 5.1
PHT 5.0
creatinine 5.0
5-oxoproline 4.8
calcium 4.8
Calcium carbonate 4.8
Phytic acid 4.8
Apocynin 4.7
TIB 4.6
Chondroitin 4.6
Tannin 4.6
Gliotoxin 4.5
Spironolactone 4.5
Fosfomycin 4.4
Uracil 4.4
Hypoxanthine 4.4
CIT 4.4
Keloid 4.3
Ceftriaxone 4.1
Crocin 4.1
Purine 4.1
PEG 4.1
DHA 4.1
Pyrazinamide 4.1
BAS 4.0
BDS 4.0
hippurate 4.0
Sulfamethoxazole 3.9
DHA 3.9
carbonate 3.9
Alendronate 3.9
Sudan I 3.9
Chlorogenic acid 3.9
DMT 3.9
Dipyridamole 3.8
Dipyridamole 3.8
Dipyridamole 3.8
Dipyridamole 3.8
phosphate 3.8
Alendronate 3.8
ammonium 3.8
Topiramate 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
Probenecid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
Ursodeoxycholic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
carbonic acid 3.7
phosphorus 3.6
Parks 3.6
ornithine 3.6
ornithine 3.6
ornithine 3.6
ornithine 3.6
ornithine 3.6
PEG 3.6
phosphoric acid 3.5
vitamin D 3.5
ATC 3.5
oxalacetate 3.4
Adenine 3.4
DHA 3.4
dCTP 3.4
AHA 3.4
ATC 3.4
SSD 3.4
ISDN 3.4
25-hydroxycholecalciferol 3.4
Formate 3.3
IPA 3.3
IPA 3.3
IPA 3.3
Chondroitin sulfate 3.3
HIS 3.3
IPA 3.2
Acetazolamide 3.2
carbonic acid 3.2
T11 3.2
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