Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0451641 (
urolithiasis
)
3,973
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Vitamin A (VA) deficiency and Tamm-Horsfall glycoprotein (THP), a protein that binds retinol and retinyl esters in canine urine, might be involved in the pathogenesis of
urolithiasis
in dogs. In the present study, we assessed levels of retinol, retinyl esters,
retinol-binding protein
(
RBP
) and THP in plasma and urine of dogs with a history of
urolithiasis
(n = 25) compared with clinically healthy controls (n = 18). Plasma retinol concentrations were higher in dogs with uroliths of struvit (P < 0.01), calcium oxalate (P < 0.05), urate (P < 0.01) and cysteine, but there were no differences in the concentrations of plasma
RBP
and retinyl esters. Excretion of urinary retinol and retinyl esters were tentatively, but not significantly higher in the stone-forming groups, which was accompanied by increased levels of urinary
RBP
(P < 0.01) and lower excretions in THP (P < 0.01). The results show that VA deficiency may be excluded as a potential cause for canine
urolithiasis
. However, the occurrence of
RBP
and a concomitant reduction of THP in urine indicates a disturbed kidney function as cause or consequence of stone formation in dogs.
...
PMID:Levels of retinol and retinyl esters in plasma and urine of dogs with urolithiasis. 1463 34
