Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0451641 (
urolithiasis
)
3,973
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The genus
Gracilaria
synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed
Gracilaria birdiae
, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from
G. birdiae
. In this study, a galactan (GB) was extracted from
G. birdiae
and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O
2
-
) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity.
Urolithiasis
affects approximately 10% of the world's population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (
HEK
-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agent.
...
PMID:Antioxidant Sulfated Polysaccharide from Edible Red Seaweed
Gracilaria birdiae
is an Inhibitor of Calcium Oxalate Crystal Formation. 3235 47
