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Query: UMLS:C0451641 (urolithiasis)
 3,973 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study aimed at presenting own experience in prevention of new urinary calculi in 18 patients with metabolically active calcium urolithiasis treated with hydrochlorothiazide in daily doses of 100 mg (group I) for 2 years, and in 6 patients with the same disease treated with magnesium oxide in daily doses 300 mg twice a day (group II) for average period of 10 months. In 9 patients a new calculus was formed during the treatment with hydrochlorothiazide, in 7 patients no recurrence was noted, and in 2 remaining patients the results were controversial (coral calculus). Therefore, patients were subdivided into group Ia (failure of hydrochlorothiazide therapy), and group Ib (no recurrence noted). Hydrochlorothiazide did not lead to the stable decrease in the saturation of the urine with calcium oxalate in group Ia whereas in group Ib (without recurrence of urolithiasis) the content of calcium oxalate in the urine was significantly lower than that in group Ia after a 2-year treatment with hydrochlorothiazide (p < 0.01) Recurrence of the disease was seen only in one patient of group II, i.e. treated with magnesium oxide. The treatment of the recurrent calcium urolithiasis is justified and efficient in those patients in whom therapy decreases the content of calcium oxalate in the urine.
Pol Tyg Lek
PMID:[Hydrochlorothiazide, allopurinol and magnesium oxide in the treatment of recurrent calcium urolithiasis]. 166 48

A case of the young female patient is presented. The patient was treated for urolithiasis for several years. The disease was diagnosed with urography only revealing urinary retention. The use of a contrast enabled to diagnose disorders of the vascularization of kidneys causing urinary retention. It is worth mentioning that atypical localization of pain in the right epigastric region additionally complicated the diagnosis.
Pol Tyg Lek
PMID:[Rotated, exceedingly movable kidney vascularized by four atypically branched arteries as a cause of periodic urinary retention in the pyelo-caliceal system and masked by biliary colic]. 263 89

The changes in calcemia and calciuria levels following low calcium diet have been studied in 35 patients with active urolithiasis and in 20 healthy subjects. Blood serum concentrations of thyroxine, cortisol and aldosterone in basal conditions as well as cortisol and aldosterone following stimulation with synacten were determined in addition. The levels of calcemia and calciuria (2.56 +/- 0.015 mmol/l and 4.70 +/- 0.41 mmol/10 mmoles of creatinine, respectively) were found to be significantly higher in patients with active urolithiasis than in healthy subjects. In addition, in patients with urolithiasis the basal blood serum concentrations of thyroxine and aldosterone were significantly higher than in healthy subjects, while the reactivity of cortisol and aldosterone secretion to synacten stimulation was normal. The results obtained suggest the participation of the described hormonal aberrations in the pathogenesis of active urolithiasis.
Endokrynol Pol 1989
PMID:[Changes in aldosterone and cortisol secretion and serum thyroxine levels in patients with active urolithiasis]. 264 Feb 2

Daily excretion of calcium, magnesium, oxalates, and citrates together with daily urine output were determined in 37 patients with calcium urolithiasis and in 25 healthy individuals. Basing on the obtained values, a degree of urine saturation with calcium oxalate with Marshall and Robertson technique and a value of risk factor with Tiselius technique were calculated. It was found that daily diuresis and excretion of calcium with the urine are significantly higher in patients with urolithiasis where as daily excretion of citrates with the urine is significantly lower than in healthy individuals. Risk index proved two-fold higher in the examined patients than in the healthy individuals (p greater than 0.001) while the degree of urine saturation with calcium oxalate did not differ significantly in both groups. The authors, discussing causes of seemingly different changes in both tested parameters, stressed diagnostic value of risk index which includes excretion of crystallization inhibitors (magnesium, citrates) and contrary to the degree of urine saturation is independent of daily urine output.
Pol Tyg Lek 1989 Feb 27
PMID:[Comparison of calcium oxalate values as indicators of risk for calcium oxalate calcinosis and the degree of urine saturation in patients with calcium urolithiasis and in healthy patients]. 281 83

Daily calcium, oxalates, magnesium, citrates and creatinine excretion with the urine was determined in 36 patients with calcium renal stones and in 25 healthy individuals. Then, risk index according to Tiselius was calculated. It was found that daily calcium excretion is significantly higher and daily citrates excretion is significantly lower in patients with calcium renal stones. Daily excretion of oxalates, magnesium and creatinine with the urine did not differ in both groups. Risk index according to Tiselius was two-fold higher in patients suffering from urolithiasis than in healthy individuals (p greater than 0.001) and better illustrated the tendency to stone formation than the analysis of metabolic disorders.
Pol Tyg Lek 1989 Feb 27
PMID:[Evaluation of risk index according to Tiselius in patients with calcium urinary stones]. 281 84

The aim of the study was to compare the renal citrate excretion and the degree of urine saturation with calcium oxalate in patients with active calcium oxalate urolithiasis and in healthy subjects under basal conditions and after alkalization. There were 20 women before menopause with calcium stone disease aged 33.5 +/- 7.1 in the first group and 20 healthy women aged 32.3 +/- 7.6 in the second one. Sodium bicarbonate was administrated intravenously in a dose 16.8 g during 2 h. 24h excretion of calcium, magnesium and citrate, the degree of urine saturation with calcium oxalate and pH of urine before and after alkalization were evaluated. Hypocitraturia occurred in 45% of patients under basal conditions. The degree of urine saturation with calcium oxalate was significantly higher in women with nephrolithiasis (p < 0.01). A significant increase of citrate excretion (p < 0.001) and a decrease of calcium excretion (p < 0.05) after alkalization took place in both groups. The degree of urine saturation with calcium oxalate decreased significantly in patients with urolithiasis and in healthy subjects. During acute alkalosis, induced by sodium bicarbonate, increase of citrate excretion was observed in patients with urolithiasis in spite of hypocitraturia under basal conditions. This indicates that kidney function following alkalization is normal in "stone kidney". Significantly decreased saturation of urine with calcium oxalate was due to the decrease of calcium excretion and the increase of citrate excretion. In conclusion, the results show that the use of alkalizing factors in prevention of recurrent calcium urolithiasis is justifiable.
Pol Arch Med Wewn 1994 Feb
PMID:[Effect of urine alkalization on excretion of renal citrate and degree of urine saturation with calcium oxalate in patients with calcium-oxalate urolithiasis and in healthy subjects]. 800 19

The study aimed at evaluating the proximal tubule function in patients with active metabolic urolithiasis with the assay of beta 2-microglobulin in the urine. The studies involved 30 patients with urolithiasis associated with chronic pyelonephritis and 31 patients with urolithiasis without pyelonephritis. Fifty healthy individuals served as a control group. Serum and urine beta 2-microglobulin concentrations were assayed with radioimmunological technique in all persons. Clearance of this microglobulin and tubular reabsorption were calculated. It was found that beta 2-microglobulin excretion with the urine is significantly higher in patients with metabolically active urolithiasis accompanied by the chronic pyelonephritis. beta 2-microglobulin clearance was significantly higher and tubular reabsorption significantly lower than those in patients without pyelonephritis and in control group. These finding suggest a dysfunction of the proximal tubule in patients with urolithiasis produced by the chronic inflammatory process in the urinary system. Negative correlation between blood serum beta 2-microglobulin levels and creatinine clearance was shown. Therefore, serum beta 2-microglobulin concentrations may be of value in evaluation of the glomerular filtration rate.
Pol Tyg Lek
PMID:[Usefulness of determining beta-2-microglobulin in serum and urine in patients with metabolically active kidney calculi and healthy individuals]. 817 Aug 11

The objective of this study was to evaluate treatment of uric acid urolithiasis and prevention of uric acid stone formation in children. We treated 18 children (11 boys and 7 girls) with uric acid urolithiasis. Complete dissolution of stones was achieved in 16 children (89%). During a two year follow-up period, 14 children (78%) were recurrence free.
Pediatr Pol 1996 Aug
PMID:[Evaluation of treatment of uric acid urolithiasis and prevention of stone formation in children]. 892 72

Various endo- and exogenous factors play a role in the urinary stones formation tract. The aim of the study was to define the type and frequency of hyperexcretion of lithogenic substances in school children population and to determine an influence of risk factors on hyperexcretion of crystallizing substances. The study included 220 school children. Preurolithiasis state (PS) was found in 30% children. The most frequently hyperoxaluria, hyperuricosuria and hypercalciuria were diagnosed and it may be connected with abnormal nutritional habits, excessive application of multivitamins, vitamin D and calcium, disturbances in drinking water chemical composition (higher amount of calcium, smaller amount of magnesium, abnormal pH). Urinary tract infections, particularly in children with obstructive uropathy are an important risk factor in the examined population. Positive familial history of urolithiasis in 43.3% children may indicate for the important role of the genetic factor in the pathogenesis of the disease.
Pol Merkur Lekarski 2000 Apr
PMID:[The role of environmental factors in the formation of kidney calculi]. 1089 97

Recurrent formation of renal calculi may be prevented by selective medical therapy designed to correct underlying metabolic disturbances in urine biochemistry. The aim of the study was to estimate potential risk factors of urolithiasis in 102 children before ESWL treatment. Metabolic disturbances followed by anatomical malformations of urinary tract, recurrent urinary tract infections caused by urease-induced microorganisms are the most frequent risk factors. In single cases possible risk factors were: immobilization and chronic corticosteroid therapy.
Pol Merkur Lekarski 2000 Apr
PMID:[Etiology of nephrolithiasis in children: own observation]. 1089 98


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