Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0451641 (urolithiasis)
 3,973 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Management of most patients with calculous disease has been less than ideal in the past. Too often therapeutic efforts were limited to symptomatic calculi. Stones were allowed to pass or were removed, metabolic studies were incomplete, victims were dismissed and forgotten, and prophylactic measures were negligible and usually confined to milk restriction and use of distilled water. More patients were crippled with and died of recurrent calculous disease, urinary infection and progressive renal insufficiency than from any other upper urinary tract abnormality. During the last decade the development of a renal stone clinic at this institution has allowed a nephrourologic approach to the management of urolithiasis. This account of classification, diagnosis and management of the various syndromes associated with urolithiasis is based on the experiences gained during the last decade with this common but ill-understood urologic problem.
J Urol 1977 Dec
PMID:Renal lithiasis: a practical approach. 33 14

Urolithiasis is seen in our region throughout the year as a periodic appearing disease with peaks not only in summer, but also--somewhat lower--in January, April and October. This appearance is especially caused by the calcium oxalate stones. Uric acid calculi show a rise between May and October. The magnesium ammonium phosphate stones appear almost completely irregular.
Wien Med Wochenschr 1979 Dec 15
PMID:[Typical annual course of urolithiasis in relation to the chemical structure of the concrements (author's transl)]. 54 53

A suspension of chalk powder was injected into the cavity of the urinary bladder of Fischer 344 rats. Three weeks later rats were divided into 4 major groups and were given a submucosal injection. One group received a suspension of viable Chapman 4909 tumor cells, the 2nd group received a suspension of frozen-killed 4909 tumor cells, the 3rd group received a suspension of normal rat spleen cells, and the 4th group received cell-free fresh tissue culture medium. After 3 additional weeks urolithiasis was recognized in each experimental group. The incidence of calculi in the groups as listed above was 14 of 17, 6 of 11, 6 of 11, and 2 of 15, respectively. In control studies inocula consisted of tumor alone, i.e., without chalk powder. Inoculation of the 4909 rat bladder cancer cell line into the lumen of urinary bladders of rats did not result in any calculi after 3 weeks but did produce intramural tumor nodules and hyperplastic changes in adjacent host urothelium in 2 of 10 rats. The tumor inoculated in the submucosa of the bladder produced calculi and papillomas in 2 of 7 rats, and it produced intramural tumor nodules with adjacent hyperplasia of urothelium in all 7 rats.
Cancer Res 1975 Dec
PMID:Bladder calculi and urothelial hyperplasia with papillomatosis in the rat following insertion of chalk powder in the bladder cavity with subsequent trauma of the bladder wall. 119 33

Between August 1987 and December 1990, 546 patients were admitted to the department of Urology at the Poh Ai Hospital of I-Lan, Taiwan, R.O.C. for the treatment of urinary stones. These urinary stone cases accounted for 50 to 60% of all urology patients admitted. The incidence of urolithiasis in I-Lan was estimated at 147/100,000 population in 1990. There were 402 male patients and 144 female patients, The male to female ratio was 2.8: 1. There were 450 upper urinary tract stones (kidney, ureter) in 314 males and 136 females, and 79 lower urinary tract stones (bladder, urethra) in 72 males and 7 females. The ratio of upper to lower urinary tract stones was 6:1. Endourological treatments such as percutaneous nephrolithotripsy and transurethral ureterolithotripsy have increased rapidly in recent years. A summary of the present analysis for composition of 365 stones follows. The most frequent type was calcium-containing stone (92.3%), followed by infection stone (4.7%), then uric acid (UA) stone (3.0%). There were no UA stones found in the female patients. According to urinalysis criteria of more than 10 WBC/HPF (x 400), pyuria was found in 67 cases of 334 metabolic stones (20.1%), and 11 cases of 17 infection stones (67.7%). There were neither pediatric case of stone formation nor cystine stones.
Hinyokika Kiyo 1992 Dec
PMID:[Clinical analysis of urolithiasis in Poh Ai Hospital of I-Lan, Taiwan, R.O.C.--a comparative study with urolithiasis in Japan]. 128 22

Glycosaminoglycans are heteropolysaccharides composed of disaccharide repeating subunits, each one containing a uronic acid component (glucuronic or iduronic acid) and a hexosamine (N-acetyl-glucosamine or N-acetyl-galactosamine, which may be differently sulphated). The presence of GAGs in human plasma has been demonstrated in several studies; they are bound to plasma proteins through non-covalent linkages. However, very little is known about either their origin or their physiological role. Due to their anionic charge, they may influence some metabolic processes, such as blood coagulation, and they could also have a role in urolithiasis and atherogenesis. Moreover, they may be important in modulating the metabolism of some lipoproteins by affecting the rate of their catabolism. Modifications of GAG pattern have been described in a few pathological conditions such as mucopolysaccharidosis, connective tissue diseases and kidney diseases. A high frequency of accelerated atherosclerosis has been observed in haemodialysis patients (HD), probably associated with the altered lipoprotein profile, which is often described in these subjects. Since GAGs may play a role in lipoprotein metabolism, we isolated and characterized plasma GAGs from a group of HD patients and a group of normal matched subjects. Quantitative analysis of plasma GAGs showed a significant increase of these polysaccharides in the HD group. Circulating levels of GAGs were 8.21 +/- 1.89 micrograms/ml in control subjects, and 15.08 +/- 3.13 micrograms/ml in the HD group (p < 0.0001). The isolation of plasma GAGs by ion-exchange chromatography produced two uronic acid containing families: a low-charge (peak I) and a high-charge (peak II) species. Both of these contained GAGs associated with plasma proteins.(ABSTRACT TRUNCATED AT 250 WORDS)
Boll Soc Ital Biol Sper 1992 Dec
PMID:[Characterization of plasma glycosaminoglycans in hemodialysis patients]. 130 20

Patients with bilateral urolithiasis diagnosed at their first visit were followed for at least one year after the start of treatment. In this retrospective study of 123 patients, the basic metabolic workup revealed no specific underlying cause of simultaneously occurring bilateral nephrolithiasis, and none of the currently used therapeutic regimes proved to be efficient in attaining clinically acceptable stone-free rates at the 3, 6 and 12-month follow-ups. Of 38 patients treated with extracorporeal shockwave lithotripsy (SWL), 21 underwent treatment of both kidneys and 10 (48%) were free of stones bilaterally after 12 months. All of the 17 patients treated with unilateral SWL failed to achieve a stone-free state on the contralateral side. In another group, treated with medication alone to minimize risks of stone recurrence, only 3 of 26 (11.5%) patients were stone-free on both sides 12 months after the start of medication. Since we achieved a stone-free state of both kidneys in no more than 12% of the non-medicated cases, it seems warranted to treat bilateral urolithiasis with SWL more frequently, particularly when patients cannot return regularly to the stone clinic for a longterm follow-up.
Tokai J Exp Clin Med 1992 Dec
PMID:Treatment of bilateral urolithiasis. 134 24

Administration of thiazide diuretics has been recommended to prevent calcium oxalate urolith development in dogs. To evaluate the effects of thiazide diuretics in dogs, 24-hour urine excretion of calcium was measured in 6 clinically normal Beagles after administration of chlorothiazide (CTZ) for 2 weeks, administration of CTZ for 10 weeks, and administration of calcium carbonate and CTZ for 2 weeks. Compared with baseline values, 24-hour urine calcium excretion did not decrease after CTZ administration. When CTZ was given at a high dosage (130 mg/kg of body weight), urinary calcium excretion was significantly (P < 0.04) higher than baseline values. Based on these observations, we do not recommend CTZ for treatment or prevention of canine calcium oxalate urolithiasis.
Am J Vet Res 1992 Dec
PMID:Effects of chlorothiazide on urinary excretion of calcium in clinically normal dogs. 147 17

The effects on the calcium oxalate urolithiasis urinary risk factors of "Rosa Canina", in herb infusion form, and magnesium chloride have been studied using female Wistar rats under balanced dietary conditions. No significant effects on the volume of liquids drunk or on creatinine, phosphate, and oxalate urinary concentrations and excretions were observed. The herb infusion did not cause any diuretic effect. Calciuria decreased and citraturia increased when taking the herb infusion, and vice versa when taking magnesium chloride. Magnesium chloride decreased the urinary pH value, but this effect was not observed when magnesium chloride was administered with herb infusion. In conclusion, the same beneficial effects of the studied infusion herb on calcium oxalate urolithiasis urinary risk factors can be clearly detected. An interesting fact is that it seems that some possible effects depend on dietary components, thus, i.e., an increase in the urinary pH was only detected when the intake of the herb infusion was studied in a magnesium chloride-supplemented diet.
Planta Med 1992 Dec
PMID:Effect of "Rosa Canina" infusion and magnesium on the urinary risk factors of calcium oxalate urolithiasis. 148 89

Adenine phosphoribosyltransferase (APRT) deficiency is one of the most common genetic diseases among the Japanese and is transmitted in an autosomal recessive manner. Urolithiasis is a typical symptom of this disease. Molecular analysis of the deficient APRT alleles revealed that 96% of disease-causing genes among the Japanese was accounted for only three alleles. Therefore, genetic diagnosis can be performed on most of the patients without determining the mutant sequence in each family. The ASO-PCR hybridization method differentiated all of these alleles. Linkage analysis using neighboring RFLP markers revealed that each of the three mutant APRT alleles had a common ancestral origin.
Nihon Rinsho 1992 Dec
PMID:[Genotype and genetic diagnosis of APRT deficiency]. 149 61

Urinary concentrations of certain biochemical constituents that play an active role in stone formation were determined in 2 h urine collections in healthy men and women (at four phases of the estrous cycle) to elucidate the sex difference in the incidence of urolithiasis. The excretion of the lithogenic substance, calcium, was higher in men than in women during phase I (p less than 0.01) and phase II (p less than 0.05) of the estrous cycle. Oxalate excretion was marginally elevated in men compared to women during each phase. Urinary citrate was lower in men compared to women during each phase (p less than 0.05). Uric acid excretion was lower (p less than 0.05) in men compared with phase I and phase III in women. Estrous phase-related alterations were also observed in the excretion of calcium and citrate in women. The data suggest that low concentrations of calcium and oxalate with an elevated citrate excretion might be responsible for the reduced risk of stone disease in women compared to men.
Clin Biochem 1991 Dec
PMID:Urinary composition in men and women and the risk of urolithiasis. 177 89


1 2 3 4 5 6 7 8 9 10 Next >>