Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0451641 (urolithiasis)
 3,973 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been shown that an acute infusion of dipyridamole increased renal phosphate reabsorption in rats and humans. A prospective study was performed to determine whether chronic treatment by dipyridamole given orally could decrease renal phosphate leak and increase serum phosphorus in patients with idiopathic low renal phosphate threshold (TmPO4/GFR < 0.77 mM). Sixty-four patients with low TmPO4/GFR were included and treated with dipyridamole (75 mg, 4 times daily) for more than 12 mo. Serum phosphorus, TmPO4/GFR, parathyroid hormone, serum calcium, and 1,25-dihydroxyvitamin D were measured sequentially before treatment, and after 3, 6 to 9, and 12 mo of treatment. Under chronic treatment with dipyridamole, TmPO4/GFR and serum phosphorus significantly increased in 80% of patients within 3 mo, with maximal values reached within 9 mo. This improvement persisted after 12 mo of treatment. In 28 patients, 1,25-dihydroxyvitamin D concentrations were above the normal range (> 42 pg/ml) and normalized in parallel with the increase of serum phosphorus. The 24-h calcium excretion (which was initially increased in patients with high vitamin D concentrations) and urolithiasis decreased under treatment. Ionized serum calcium and parathyroid hormone remained unchanged. After 2 yr, treatment was discontinued in three patients; serum phosphorus and TmPO4/GFR decreased within 1 mo after discontinuation. Dipyridamole at a dose of 75 mg 4 times daily increases low TmPO4/GFR and improves hypophosphatemia in patients with renal phosphate losses and can be used to treat these patients.
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PMID:Dipyridamole decreases renal phosphate leak and augments serum phosphorus in patients with low renal phosphate threshold. 964 37

To study the structure of the risk factors and features of the course of a primary and recurrent myocardial infarction in elderly and old age we investigated 443 patients in the first 48 hours of the disease. Significant prevalence of risk factors was established in men with myocardial infarction in St. Petersburg. In most patients, especially with recurrent myocardial infarction, three or more risk factors were determined at the same time, which indicates a high coronary risk. The most frequently we observed the dislipoproteinemia, arterial hypertension, psycho-emotional stress, heart failure in anamnesis, link of disease to the season of year, the frequency of acute respiratory infections and colds, cardiac arrhythmia in anamnesis, smoking and alcohol abuse. Among the associated diseases, the cholelithic disease, urolithiasis and chronic bronchitis prevailed, especially with recurrent myocardial infarction. In the clinical pattern of disease in the first 24 hours, symptoms of heart failure prevailed. Anginal variant of a recurrent myocardial infarction occurs even less frequently, and symptoms of heart failure are more expressed, especially in prognostically unfavorable patients.
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PMID:[Risk factors and features of the course of primary and recurrent myocardial infarction in elderly and aged men]. 2103 83