Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0451641 (urolithiasis)
 3,973 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Urinary tract infection (UTI) is the most common infection disease in all age. From the pediatric urology point of view, difficulty in bladder emptying is the most favorable factor for UTI. Early ultrasonographic (USG) investigation is necessary to detect urinary obstruction and urolithiasis. It is important to perform USG with filled bladder and directly after micturition. Voiding cystourethrogram (VCUG) should be done after UTI in small children (below 3 years of age). For the detection of renal damage the DMSA-scan is the most sensitive method that should be performed during UTI and 6 months later. In case of bladder dysfunction suspicion the uroflowmetry is substantial. Detection of leucocyturia give rise to microbiological diagnosis and proper treatment. UTI with fever needs antibiotic therapy started in first 24 hours to prevent renal damage. Risk factor for recurrences are bladder dysfunction and residual urine. Prophylaxis should not be restricted to the use of antibiotics or other prophylactic agents but must include the efficient management of bladder and bowel dysfunction and proper liquids administration.
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PMID:[Urinary tract infections in children by pediatric urologist]. 2156 36

To assess the functional effects of percutaneous nephrolithotomy (PCNL) and its outcomes in the operated kidney, we prospectively studied 30 consecutive cases undergoing PCNL. Kidney function was evaluated preoperatively and 3 months after surgery with serum creatinine, glomerular filtration rate (GFR), and with (99m)Tc-DMSA SPECT-CT scans to determine the differential renal function (DRF). PCNL effects in the operated kidney DRF were considered globally (DRFPLANAR, DRFSPECT) and in the region of percutaneous access (DRFACCESS). PCNL functional impact was also assessed depending on its outcomes, namely success (stone-free status) and the development of perioperative complications. PCNL has rendered 73 % of the cases completely stone free with a 33 % complication rate. After PCNL, serum creatinine and GFR did not change significantly, whereas DRFPLANAR and DRFSPECT dropped 1.2 % (p = 0.014) and 1.0 % (p = 0.041), respectively. The highest decrease was observed in DRFACCESS (1.8 %, p = 0.012). Stone-free status after PCNL did not show any impact on kidney function. Conversely, cases that suffered from a complication showed impairment in serum creatinine (0.1 mg/dL, p = 0.028), in GFR (11.1 mL/min, p = 0.036) as well as in DRFPLANAR (2.7 %, p = 0.018), DRFSPECT (2.2 %, p = 0.023) and DRFACCESS (2.7 %, p = 0.049). We conclude that PCNL has a minimal impact on global kidney function, which is mainly located in the region of percutaneous access. The advent of perioperative complications increased PCNL functional damage, whereas the stone-free status did not show any meaningful effect.
Urolithiasis 2014 Oct
PMID:Does percutaneous nephrolithotomy and its outcomes have an impact on renal function? Quantitative analysis using SPECT-CT DMSA. 2507 14