Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0451641 (urolithiasis)
 3,973 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The analysed material includes 100 children with urolithiasis treated in the Pediatric Clinic of the National Research Institute of Mother and Child in Warsaw between 1976 and 1978. Patients' age was from 3 months to 18 years. The analysed group included 51 boys and 49 girls. Urinary tract infection was found in 54 cases, i.e. 57,4% of the analysed material. The most common bacterial strains were those producing urease. They were detected in 48 children i.e. 88,9% of cases with urinary tract infection. Mostly these were bacteria of Proteus group--sporadically Pseudomonas aeruginosa and Staphylococcus albus. In the analysed patients urinary tract obstruction was observed in 36 children, i.e. 36% of cases. In 77% of the analysed material, localization of concrements was in upper urinary tract in 19% in the ureters and in 4% in the lover urinary tract. While in adult patients the most common compound of urinary stones was calcium oxalate, in children the most common stone compounds were phosphates (found in 38 cases i.e. 58,4% of the analysed material). The second frequent compound was oxalate found in 20 cases (30,7%). Less frequent compounds were uric acid and cystine. Performed study allowed to establish the cause of urolithiasis in 93 out of 100 examined children. Metabolic reasons of urolithiasis were found in 26 cases, i.e. 26% of the analysed material. They were as follows: idiopathic hypercalciuria--12 cases, uric acid urolithiasis--8 cases, primary hyperoxaluria--3 cases, cystinuria--2 cases, and incomplete acidosis of distal renal tubuli--1 case. Urolithiasis of probably metabolic origin was detected in 13 children (13%). Other reasons of urolithiasis in children were: infection (31%), idiopathic urolithiasis (17%) and others (6%). In 7 cases the reason of urolithiasis was not established.
 ...
PMID:[Metabolic etiology of urinary calculi in children]. 717 91

Sixty-eight children (ages ranging from 5 months to 16 years) with urolithiasis were treated between 1966 and 1979. There were 36 females (53%) and 32 males (47%). Sixteen children (24%) had associated urinary tract infection; 4 out of these (6%) presented with urinary tract malformation. Fifty-five calculi (89%) were found in the upper urinary tract (kidney and ureter); 24 of the chemically studied calculi (80%) were made of calcium salts. In 30 children, metabolic investigations were carried out, leading to the discovery of hypercalciuria in 17 (57%). In one patient, important vesico-ureteral reflux associated with urolithiasis led to renal failure.
 ...
PMID:[Urolithiasis in Isreali children (author's transl)]. 723 27

Struvite (magnesium ammonium phosphate) uroliths are found more frequently in the urinary tracts, of dogs than are other types of uroliths. Infection of the urinary tract with urease-producing bacteria, especially staphylococci, plays an important role in urolith formation. An inherited predisposition to urinary tract infection may be associated with the high rat of occurrence of struvite uroliths in some dogs. Diagnosis of struvite urolithiasis should encompass analysis of the mineral composition of calculi and identification of concomitant urinary tract infection. Since urinary tract infections occur as sequelae to abnormalities in local or systemic host-defense mechanisms, appropriate effort should be directed toward detection of these abnormalities. Therapy of struvite urolithiasis should encompass relief of obstruction to outflow when necessary, elimination of existing calculi, eradication or control of urinary tract infection, and prevention of recurrence. Although surgical removal remains as the preferred method to eliminate struvite uroliths from dogs, nonsurgical methods of urolith dissolution should be considered. Recurrence of struvite uroliths may be prevented by various combinations of antimicrobial therapy, administration of urease inhibitors, acidification of urine, and induction of diuresis.
 ...
PMID:Canine struvite urolithiasis: problems and their dissolution. 728 47

It is difficult to define and diagnose urinary obstruction in a meaningful way only by radiographic methods and without involving a urodynamic concept. Urinary infection, urolithiasis and elevated arterial blood pressure are the most common complications found with urinary obstruction. In 70 patients with obstruction of the pelviureteral junction we found infection in 15.7 percent, lithiasis in 27 percent, and arterial hypertension in 27 percent.
 ...
PMID:[Clinical problems in urinary obstruction (author's transl)]. 735 28

Magnesium ammonium phosphate calculi developed in the urinary bladders and urethras of four of five offspring of Miniature Schnauzer parents with recurrent struvite urolithiasis. Calculi were detected by radiograhy when the dogs were 12 to 15 months old. Males and females were affected. A significant number of urease-producing staphylococci were identified in the urine of three of four dogs before urolith formation, and in one dog after urolith formation. The dogs were evaluated until they were 26 months old. Serum concentrations of calcium, phosphorus, and magnesium were inside usual limits throughout the study. Abnormalities that might predispose to urinary tract infection were not identified by radiography or necropsy studies. In one dog, bladder calculi recurred after surgical removal of multiple cystoliths. In another, urethral obstruction and acute generalized pyelonephritis induced a lethal uremic crisis. Gross and microscopic lesions, detected after necropsy of all dogs with uroliths, were typical of bacterial infection.
 ...
PMID:Struvite urolithiasis in a litter of miniature Schnauzer dogs. 740 90

Bacteriuria due to Salmonella typhi usually occurs following recent typhoid fever or in chronic carrier states. Data from 18 patients with S. typhi bacteriuria, seen during 5 years, were analyzed. Fourteen patients had localized urinary tract infection due to S. typhi. Four others had bacteriuria, probably associated with typhoid fever. Localized abnormalities of the urinary tract and kidneys and also systemic diseases were found to predispose patients to S. typhi bacteriuria. Local abnormalities encountered included urolithiasis (n = 3), prostatic hypertrophy (n = 1), and tuberculosis (n = 1). One renal transplant recipient and another with lupus nephritis had S. typhi bacteriuria. One had associated strongyloidosis, and another was pregnant.
 ...
PMID:Significance of Salmonella typhi bacteriuria. 754 80

Urolithiasis is rare in childhood (about 1%) and commonly associated with urinary tract infection. Like in adults ESWL is the minimally invasive treatment and therefore primary therapeutic approach. However, the passage of stone debris is less complicated than in adults and auxiliary measures are seldom needed. There is no evidence of soft tissue damage after ESWL, but in aspect of the growing organ lithotriptors with small focal zone and ultrasound location system are preferable. Obstructive anatomical abnormalities, if so, must be treated simultaneously. For prevention a strict antibiotic (longterm) therapy, according repeat antibiograms, and exclusion of metabolic disease are essential. Medication as well as special diets must be handled carefully or avoided as they might induce growth disorders.
 ...
PMID:[Urolithiasis in children]. 757 47

A case of gangrene of the penis, rarely seen at our University Hospital is reported. Urolithiasis, urinary tract infection, infected piles and anaemia were found to be associated with the condition. Because of rapid spread of the gangrene, partial amputation was required in this reported case.
 ...
PMID:Gangrene of the penis. 775 62

Urolithiasis in children is uncommon. We present the case of a 10-year-old boy with anuria resulting from an obstructing stone in the urethral meatus. There are no previously reported cases of pediatric urolithiasis presenting with anuria. We review urolithiasis in children, including predisposing factors, clinical features, stone composition, and natural history. The diagnosis may be confusing in younger children but should be considered with complaints of flank or abdominal pain, hematuria, and urinary tract infection.
 ...
PMID:Urolithiasis in a child: an uncommon presentation of an uncommon disease. 775 11

Records of 90 urolithiasis patients (50 boys and 40 girls) of 5 months to 18 years old (medium 8.7 yr) treated in our department from 1975 to 1993 were reviewed. Family history was found in 25 (27.7%), concomitant uropathy in 9 and predisposing factors to lithogenesis in 35 patients. The most frequent clinical manifestations were hematuria, lumbalgia, dysuria and calculus elimination. Urinary tract infection was found in 26 cases. Treatment modalities used were: medical in 31, extracorporeal shock wave lithotripsy (ESWL) in 12 surgery en 28, endoscopy en 1 and instrumental in 1. Six of 28 surgically treated patients presented residual urolithiasis and another 6 relapsed. Three complications were registered. Recovery from hydronephrosis and/or vesicoureteral reflux was seen in all patients with these lesions.
 ...
PMID:[Course of the urinary lithiasis treatment in the Surgery Department of a Children's Hospital]. 776 77


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>