Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0451641 (urolithiasis)
 3,973 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sulfadiazine-related stones are uncommonly reported, but they could be increasingly encountered owing to the use of sulfadiazine for human immunodeficiency virus-related toxoplasmosis. We report on their unusual imaging characteristics, with 4 such stones having very low attenuation compared with more commonly encountered stones. Because their atypical appearance resulted in delayed treatment for our patient in acute renal failure and because the computed tomography imaging characteristics have not been previously defined, we report the findings of stone analysis-confirmed sulfadiazine-related urolithiasis.
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PMID:Radiographic characteristics of sulfadiazine urolithiasis. 1870 Nov 49

A patient with newly-diagnosed HIV infection and biopsy-proven cerebral toxoplasmosis was treated with sulphadiazine and pyrimethamine. Despite adequate hydration and daily examination of urine for sulphadiazine crystals obstructive uropathy due to bilateral ureteric stones with hydronephrosis occurred, resulting in rapid onset renal failure. Sulphadiazine was discontinued and clindamycin was substituted. With intravenous fluid hydration and bilateral nephrostomies the urolithiasis resolved. This case serves to remind clinicians of the need for vigilance when treating cerebral toxoplasmosis with sulphadiazine, in order to avoid this potentially serious complication of treatment.
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PMID:Sulphadiazine-induced obstructive renal failure complicating treatment of HIV-associated toxoplasmosis. 2258 77