Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0451641 (urolithiasis)
 3,973 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

622 patients were operated on between 1966 and 1988. Urolithiasis was the most common presenting symptom (26%) but routine measurements of serum calcium led to detect 50% cases. At present, the disease is three times more frequent in women than in men. Estrogenic deprivation, neck irradiation (3.4%) and lithium therapy favor the occurrence of hyperparathyroidism (HPT); frequent association with goiter (19.8%), diabetes (8.3%) and multiple endocrine neoplasia (3.5%) has been noticed. Bone Gla protein concentrations correlate with calcium and HPT blood concentrations but do not reflect the severity of bone damage. Dual photon absorptiometry is now available for quantification and follow-up of bone demineralization, especially in asymptomatic forms of HPT.
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PMID:Current concepts in primary hyperparathyroidism. 261 94

The principles of working classification of human pathology associated with excess, deficiency and dysbalance of trace elements are presented on the basis of many-year analysis of the literature and own experimental and clinico-morphological observations. According to the most important variants of human contact with the environment abnormal with regard to the content of trace elements, the following types of diseases are distinguished: (1) natural, (2) technogenic, and (3) iatrogenic. In their turn, technogenic diseases are subdivided into industrial, neighbouring, transgressive. Among these diseases, monomicroelementoses and polymicroelementoses should be distinguished. The former include fluorosis, arsenosis, berilliosis, cadmium nephropathy, cobalt myocardiopathy, etc., the latter anemias of biogeochemical nature, endemic goiter, tooth caries, urolithiasis, selenium-deficient myocardiopathy, and others.
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PMID:[Principles for classification of diseases of a biogeochemical nature]. 665 43