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 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Angiographically determined changes in segmental wall motion (SWM) and ejection fraction (EF) are sensitive indices of left ventricular (LV) function. To compare the effects of exercise on LV function, first pass radionuclide angiocardiography was used before and during maximal upright bicycle stress in patients with nonsignificantly stenosed coronary arteries, and in those with greater than 75% stenosis. Gamma camera acquisitions were made in the 30 degree RAO projection using a 20 mCi I.V. bolus of 99mTc-pertechnetate. In the control group (seven normals, one nonsignificant (CAD) the EF significantly increased between rest and exercise (0.65 +/- 0.03 to 0.81 +/- 0.03 (mean +/- SEM), p less than 0.005). In this group SWM measured over the two anterior and two inferoposterior segments uniformly increased. In the 11 patients with a history of angina and significant coronary artery obstruction, the EF did not change in three and significantly decreased in the remaining eight (0.57 +/- 0.04 to 0.45 +/- 0.03, p less than 0.005). In all 11 patients SWM either decreased or did not increase in the areas supplied by the significantly stenosed coronary arteries. Upright maximal stress angiocardiography appears to be well-suited for diagnosing ischemic heart disease and localizing the area of ischemic dysfunction.
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PMID:Effects of maximal exercise stress on left ventricular function in patients with coronary artery disease using first pass radionuclide angiocardiography: a rapid, noninvasive technique for determining ejection fraction and segmental wall motion. 75 25

Using multigated radionuclide ventriculography (RNV), the left ventricular (LV) phase histogram (PH) was used to quantitate LV synchrony at rest and at submaximal and maximal supine exercise in 10 normal and 10 coronary (CAD) patients. Each LV PH was obtained by masking the phase image with an LV region, generated semiautomatically and modified if necessary to minimize ambiguity of LV delineation. The shape and spread of each histogram was characterized by its standard deviation (SD) and skewness (SK). Normals had a tight resting PH with slight negative skewness (SD = 9.06 +/- 0.22 (mean +/- SEM; SK = -0.53 +/- 0.05). CAD patients had a wider resting PH with a larger SD and a significantly more positive skewness reflecting greater contractile asynchrony (SD = 16.53 +/- 2.26; SK = 0.35 +/- 0.22). With exercise the PH distribution for the normals remained tight (SD = 8.1 +/- 0.24) while SK changed little (SK = -0.29 +/- 0.04). In contradistinction, with exercise CAD patients markedly increased the spread of their LV PH (SD = 27.42 +/- 3.77) and increased the number of late pixels (SK = 0.75 +/- 0.15). It is concluded that quantitative PH analysis is a useful adjunct for the analysis of regional asynergy during resting or exercise radionuclide left ventriculography.
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PMID:Quantitative phase analysis of exercise radionuclide left ventriculography in normals and patients with coronary artery disease. 683 32

Radionuclide multigating of the cardiac cycle was employed to assess effects of angiotensin infusion on left ventricular function. In six normal subjects, angiotensin infusion decreased heart rate (HR) from 72 +/- SEM 2 to 57 +/- 2 beats/min (P less than 0.001); while systolic blood pressure (BP) increased from 119 +/- 2 to 178 +/- 1 mm Hg (P less than 0.001), and ejection fraction (EF) declined from 58 +/- 1 to 47 +/- 2 percent (P less than 0.05). In contrast, in 11 normal subjects, supine exercise increased HR and systolic BP by 55 and 49 percent, whereas EF increased from 64 +/- 1 to 71 +/- 1 (P less than 0.001). In ten patients with CAD, angiotensin infusion produced no change in HR, increased systolic BP by 34 percent, and decreased EF by 11 percent. Angiotensin infusion induced left ventricular depression in normal subjects and in patients with CAD. It cannot substitute for exercise in intervention radionuclide ventriculography.
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PMID:Angiotensin infusion effects on left ventricular function. Assessment in normal subjects and in patients with coronary disease. 735 11

In order to evaluate whether Lp(a), a lipoprotein that is potentially thrombogenic and atherogenic, is a potential risk factor for CAD in non-insulin-dependent diabetes (NIDDM), we compared the Lp(a) and its distribution in 145 NIDDM patients with that in 94 healthy control subjects. Furthermore, we studied the effect of insulin treatment on serum Lp(a) in 108 patients with NIDDM. Male and female NIDDM patients had similar Lp(a) concentrations to healthy controls (median value 167 mg L-1, range 15-1550 mg L-1 vs. 157 mg L-1, range 15-919 mg L-1, NS and 92, range 15-1190 mg L-1 vs. 103 mg L-1, range 15-842 mg L-1, NS). Also, the cumulative distribution of Lp(a) did not differ between the NIDDM patients and healthy subjects. Insulin treatment increased Lp(a) in diabetics with a Lp(a) concentration of less than 300 mg L-1, but this effect was not related to the concomitant improvement in metabolic control (mean change (+/- SEM) of HbA1c from 9.80 +/- 0.15 to 8.00 +/- 0.12; P < 0.001). In subjects with elevated Lp(a) concentrations (> 300 mg L-1) the Lp(a) concentration was unaffected by insulin, despite a similar improvement in glycaemic control. These results suggest that insulin may modulate the concentration of Lp(a).
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PMID:Effect of insulin treatment on serum lipoprotein(a) in non-insulin-dependent diabetes. 778 67

This in vitro study compared the marginal adaptation of CAD/CAM and laboratory-made ceramic inlays before, during and after loading. Six MOD inlay preparations of standardized design with one cervical margin in dentine and the other in enamel were prepared for each inlay type: CAD/CAM fabricated MGC-glass ceramic inlays, CAD/CAM fabricated feldspathic porcelain inlays, laboratory-made glass ceramic inlays and laboratory-made feldspathic porcelain inlays. Appropriate luting composite materials were used. The restored teeth were subjected to occlusal loading, thermal cycling, toothbrush-toothpaste abrasion and chemical degradation in vitro. Marginal adaptation was quantitated along the entire length of the cavosurface margin and along selected sections of the margin using SEM, following in vitro testing corresponding to 0, 0.5, 1.0, 2.7 and 5.0 years of clinical service. In addition, marginal fit of the cemented inlays was evaluated in the SEM. The initial marginal adaptation in enamel was excellent in all groups. After in vitro testing, significant marginal discrepancies were found in all groups. A high percentage of marginal openings was recorded, notably in the cervical portions of the margins in both enamel and dentine.
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PMID:Marginal adaptation and fit of adhesive ceramic inlays. 842 82

The purpose of the investigation was to examine the marginal and internal fit of Cerec anterior crowns and crown copings. The marginal and internal fit of Cerec anterior crowns (n = 18) and copings was examined on each of six anterior model tooth preparations, with different types of butt-margin crown preparation design on different teeth: 1.) straight flat (tooth 22), 2.) following the CEJ with mid-approximally steep curvature angles of 90 degrees mesial and 40 degrees distal (tooth 21) and 3.) same as 2, but with obtuse angles of 130 degrees and 150 degrees (tooth 41). The anterior crowns were machined on Cerec 2 units using Mark II ceramic (Vita), and the Cerec copings using In-Ceram Spinell (Vita). Laboratory slip-cast In-Ceram spinell anterior crown copings served as controls (n = 18). All reconstructions were seated (with adhesive) on the preparations, and the width of the marginal interface was measured circumferentially using SEM at 150x magnification. After cross-sectioning all samples in the bucco-oral direction, the internal fit was measured using this same technique. The marginal width of computer machined Cerec CAD/CIM anterior crowns (59.9 +/- 5.6 microns) was significantly (p < 0.01) lower than that of machined (73.4 +/- 12 microns) and slip-cast In-Ceram spinell copings (75.5 +/- 17 microns). The internal fit values of the slip-cast copings (94.1 +/- 20 microns) were significantly (p < 0.001) lower than those of the Cerec Mark II anterior crowns (141.3 +/- 21 microns) and copings (146.8 +/- 17 microns). Cerec CAD/CIM machined anterior full-ceramic crowns and copings showed excellent fit in comparison with slip-cast In-Ceram spinell copings. In terms of the marginal and internal fit, there were no significant differences (p > 0.05) between the different butt-margin preparation designs. Selected clinical cases demonstrate the high esthetics of anterior Cerec crowns.
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PMID:Full-ceramic CAD/CIM anterior crowns and copings. 1135 94

An experiment was conducted to test the effect of dietary cation-anion difference (CAD, Na(+) + K(+)-Cl(-), mEq/kg diet) and xylanase addition on feed consumption, digestibility of nutrients, plasma electrolyte balance and growth performance in young pigs. A 2 x 3 factorial arrangement with three dietary CAD levels (-100, 200, and 500 mEq/kg) and two levels of xylanase supplementation (0 and 0.1% xylanase derived from Trichoderma longibrachiatum) was used. Thirty-six individually housed, castrated pigs (5 weeks old) with an initial body weight of 9.34 +/- 0.28 kg (mean +/- SEM) were randomly assigned to the six treatments. Diets were provided to pigs as cold pellets. Pigs had ad libitum access to feed and water. Venous plasma Cl(-) concentration was higher (p < 0.0001) in dietary CAD of - 100 mEq/kg group compared with the other two CAD groups. Dietary CAD did not affect Na(+) and K(+) concentrations in the venous plasma. Growth rates were higher (p < 0.05) in pigs receiving dietary CAD of 200 mEq/kg (657 g/pig.day) and dietary CAD of 500 mEq/kg (603 g/pig.day) than in pigs receiving dietary CAD of -100 mEq/kg (484 g/pig.day). Faecal dry matter and nitrogen decreased with increasing dietary CAD. Faecal apparent digestibility of dry matter and nitrogen was higher (p < 0.05) in the dietary CAD of 500 mEq/kg compared to the two lower level CAD groups. Supplementation of xylanase did not affect the performance of pigs. Xylanase addition in the diet significantly increased apparent faecal digestibility of dry matter and tended to increase apparent digestibility of nitrogen. No interaction between dietary CAD and xylanase was found. In conclusion, dietary CAD influenced the performance and digestibility of nutrients of pigs. Xylanase supplementation improved digestibility of dry matter.
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PMID:Feed intake, growth, digestibility of dry matter and nitrogen in young pigs as affected by dietary cation-anion difference and supplementation of xylanase. 1168 78

This review qualitatively and quantitatively compares the gross shape and size of lenses from different species as a function of their fibre cell organization. Grossly, all vertebrate lenses are asymmetrical, oblate spheroids with size and spheroidicity that varies considerably between species. Correlative LM and SEM analysis of the basic structural element of lenses, the fibre cell, shows that the average equatorial fibre width and thickness is relatively constant between most species. This indicates that inter-species differences in lens size is primarily a function of fibre number. Comparable analysis demonstrates that lens spheroidicity is due at least in part, to differences in the average anterior and posterior fibre end segment thickness in relation to that at the equator. In addition, the above analysis, supplemented by 3D-CAD reconstructions, illustrates how lifelong lens growth produces crescent fibres, that become arranged in age-related, concentric growth shells overlaid in slightly imprecise register. The reason for the non-exact registering of growth shells is that, while the vast majority of fibres are hexagonal in cross-section, a very small minority are pentagonal in cross-section and of inconstant width and thickness. Hexagonal and pentagonal fibres are required because the increase in the circumference of successive growth shells is frequently less than the widths of hexagonal fibres. Thus, lens growth is likely accomplished by a combination of the addition of successive growth shells containing more fibres, as well as by the addition of growth shells containing equal numbers of fibres that are incrementally wider as a function of radial location. Finally, SEM analysis, supplemented by 3D-CAD reconstructions, highlights the fact that the end-to-end arrangement of fibres within growth shells, the suture patterns, is not identical in all vertebrate lenses. This is important because lens optical quality is directly related to lens suture type and a negative influence of sutures on lens optical quality increases with age and as a result of some ocular surgeries (vitrectomy and trabeculectomy). These facts suggest that future research efforts should be directed at determining the factor or factors that influence or direct the differences in fibre shape, size and organization in branched and unbranched suture lenses.
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PMID:Fibre cell organization in crystalline lenses. 1510 47

The diamond burs of two dental CAD/CAM systems (GN and CD) were examined if they could be used to fabricate up to 21 ceramic full crowns without fracture. After one, 11, and 21 machining times, the surfaces of the diamond burs were observed and the number of particles captured on SEM pictures was counted. The average surface roughness of the crowns was also measured. All diamond burs could be used to fabricate 21 ceramic crowns without fracture. A significant decrease in the number of diamond particles was found on the surfaces of GN burs after 11 and 21 machining times, but not on those of CD burs. The average surface roughness of GN crowns significantly increased with increase in the number of machining times. A significant positive correlation was found between the average surface roughness and the number of diamond particles.
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PMID:Durability of diamond burs for the fabrication of ceramic crowns using dental CAD/CAM. 1588 Dec 20

Evaluation of the marginal and internal fit of all-ceramic molar crown-copings hypothesizing that Computer Aided Design/Computer Aided Manufacturing (CAD/CAM) fabrication shows the same accuracy of fit as conventional techniques. A set of six individual crown preparations was duplicated 12 times yielding 72 plaster dies. Slip-cast (In-Ceram Zirconia), heat-pressing (Empress II) and CAD/CAM crown-copings (Cerec inLab, DCS, Decim and Procera) were seated on 12 dies each. Marginal and internal gap width was measured in the SEM at 120x magnification. Marginal gap of slip-cast (25 +/- 18 microm) was significantly (P < 0.05) smaller than that of Empress II (44 +/- 23 microm) copings. Procera (17 +/- 16 microm) and Decim (23 +/- 17 microm) did not differ (P > 0.05) from slip-cast (25 +/- 18 microm) but were smaller (P < 0.001/P < 0.01) than Empress II (44 +/- 23 microm) and Cerec inLab (43 +/- 23 microm) (P < 0.001/P < 0.05). DCS (33 +/- 20 microm) did not differ (P > 0.05) from any of the others. The internal mid-orobuccal gap width of Procera (136 +/- 68 microm) was larger (P < 0.001) than that of Decim (81 +/- 30 microm) and slip-cast (94 +/- 84 microm) (P < 0.05) while Empress II (105 +/- 53 microm), DCS (110 +/- 79 microm) and Cerec inLab (114 +/- 58 microm) did not differ significantly (P > 0.05) from Decim, Procera and slip-cast. Internal mesiodistal gap width was similar. The fit of conventional and CAD/CAM all-ceramic molar crown-copings covered the same range of gap width confirming the assumed hypothesis.
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PMID:Marginal and internal fit of all-ceramic CAD/CAM crown-copings on chamfer preparations. 1589 23


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