Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0432222 (SEM)
 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Little information is available on the effect produced by antiepileptic drugs on the serum beta-glucuronidase activity. According to recent findings, beta-glucuronidase serum levels are increased in patients with epilepsy just before the beginning of seizures and remain increased during several weeks; this it is suggested that determination of this enzyme could be important in the provision and the treatment of seizures. The purpose of the present study attempts to understand these changes. Our study was carried out on 49 adult healthy subjects and 48 adult epileptic patients receiving anticonvulsant therapies. Serum beta-glucuronidase activity was determined by a simplified procedure employing phenolphtalein glucuronic acid as substrate. The mean +/- SEM of serum beta-glucuronidase activity in treated patients (40.93 +/- 5.01 MSU/ml) was significantly higher than those of the healthy subjects (25.04 +/- 3.40 MSU/ml). In conclusion, the relationship between changes in serum enzyme activity, seizures and anticonvulsant therapies suggests that the determination of serum beta-glucuronidase activity presents a weak interest in predicting or treating seizures.
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PMID:[Serum beta-glucuronidase activity in patients with epilepsy]. 235 28

For dye-sensitized solar cell (DSSC), highly ordered nanoporous TiO2 materials with crystalline frameworks were successfully synthesized from different silica templates including SBA-15, KIT-6 and MSU-H. A photoelectrode in DSSC was fabricated by adsorbing cis-bis(isothiocyanato)bis(2,2'-bipyridyl-4,4'-dicarboxylato)-ruthenium(II)bis-tetrabutylammonium dye (N719) onto the prepared TiO2 nanoparticles. The samples were characterized by XRD, TEM, FE-SEM, AFM and Brunauer-Emmett-Teller (BET), and FT-IR analysis. An investigation of the influence of the bonding structure of N719 dye and nanoporous TiO2 on the photovoltaic performance of DSSC revealed that the bonding structure of N719 on TiO2 films is caused by the unidentate and bidentate linkage. Based on the overall conversion efficiency (eta), fill factor (FF), open-circuit voltage (V(oc)) and short-circuit current (/sc) from the I-V curves measured, it was observed that the photoelectric performance is strongly dependent on the dispersion properties of the nanoporous TiO2 replicas from mesoporous silica templates.
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PMID:Photovoltaic performance of nanoporous TiO2 replicas synthesized from mesoporous materials for dye-sensitized solar cells. 1919 74

Submicron particles of mesoporous MSU-2 silica have been obtained by using Tergitol NP-9 as nonionic surfactant and TEOS as silica precursor. The material has been chemically modified with 5-mercapto-1-methyltetrazole and characterized by powder X-ray diffraction, TEM, SEM, N2 adsorption, FT-IR spectroscopy, 29Si-NMR spectroscopy, thermogravimetric analysis and elemental analysis. The enviromental application of such material (denoted MTTZ-MSU-2b) in the treatment of heavy metal-contaminated waters has been demonstrated. The maximum adsorption capacity of this material was found to be 0.73 +/- 0.01 mmol/g for Pb(II) and 0.94 +/- 0.01 mmol/g for Zn(II), and is higher than the capacity of most of the other functionalized mesoporous materials previously reported. The very high access of these metal ions to the binding sites in the adsorbent has also been demonstrated (adsorption efficiency equal to 0.88 and 1.13 for Pb(II) and Zn(II), respectively).
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PMID:Synthesis and characterization of novel mesoporous silicas of the MSU-X family for environmental applications. 1992 67

Cationic polyelectrolyte was first used as the additive in the nanoshear hybrid alkaline pretreatment of corn stover. The novel nanoshear hybrid pretreatment process was recently developed at MSU. The chemical compositions and morphologies were investigated by SEM, TEM, confocal CLSM, and XPS to elucidate the degradation mechanism of cellular structures. At room temperature and fast processing conditions (~2 min), lignin was found to redistribute on the inner and outer surfaces of the cell wall as lignin aggregate droplets instead of being extracted. Free microfibrils in the residues were also observed. The yields of enzymatic hydrolysis were enhanced for the pretreated corn stover with the aid of polyelectrolyte as an additive. We speculate that lignin was effectively modified which opened up the cell wall structure during the short pretreatment process and prevented non-productive binding of enzymes in the enzyme hydrolysis reaction.
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PMID:Impact of cationic polyelectrolyte on the nanoshear hybrid alkaline pretreatment of corn stover: morphology and saccharification study. 2342 78