Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0432222 (SEM)
 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients undergoing partial liquid ventilation (PLV) are often monitored with pulmonary artery catheters and receive positive end-expiratory pressure (PEEP). PEEP can dissociate wedge pressure (Pcw) from transmural left atrial pressure (Platm) by elevating pleural pressure and can dissociate Pcw from Pla by elevating alveolar pressure, PLV, like PEEP, also elevates pleural and alveolar pressures. However, the artifacts PLV may cause in measured vascular pressures are unknown. In 6 anesthetized, paralyzed healthy adult sheep, we compared effects of gas ventilation (GV) and PLV with 10 and 30 ml/kg perflubron on pericardial pressure (Pperi), Pcw, Pla, thermodilution cardiac output, and pulmonary artery flow measured with a doppler probe. PEEP was applied from 0-15 mm Hg during GV and PLV. PLV changed pericardial pressure or cardiac output minimally (at PEEP(0), GV: Pperi = -1.7 +/- 0.6 mm Hg, CO = 3. 2 +/- 0.1 L/m; 10 ml/kg perflubron: Pperi = -1.3 +/- 0.6 mm Hg, CO = 3.4 +/- 0.2 L/m; 30 ml/kg perflubron: Pperi = -1.6 +/- 0.7 mm Hg, CO = 3.4 +/- 0.2 L/m; all mean +/- SEM). On PEEP, Pcw agreed with Pla and Platm as well or better during PLV as during gas ventilation. Cardiac output by thermodilution and probe agreed equally well under all conditions. We conclude that hemodynamic values are as accurate during PLV as during gas ventilation.
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PMID:Accuracy of hemodynamic measurements during partial liquid ventilation with perflubron. 1102 47

As a significant discovery in the 20th century, carbon nanotubes are attracting particular attention in many unique fields such as electronics, catalysts, hydrogen storage composites, gas sensors, drug delivery, medical diagnostics, therapeutics and nanofluids. In this project, we focus on self-assembled synthetic special natural protein alpha-lactalbumin nanotubes with different (straight, waved, coiled, regularly bent, branched, beaded) shapes, nanospherical particles, nanorods, nanowires, nanopores, polyhedral (hexagonal network, spherical, cubic) nanostructures, nanochannels, nanofibers, nanosheets, nanoleaves, nanowave branched structures, nanobeads, nanoflowers, nanocapsules, novel nano-hybrids consisting of tubes and rods (new core-shell), nanocrystal shapes, apiary or cobweb, branched nanotubes with Y-junctions, nano membrane structures, nano sweep symmetrical shape, nano sponge structures, nano helical homogeneous structures and nano perpendicular and horizontal stable hollow single-walled natural protein nanotubes (NPNTs). These were successfully synthesized by the chemical hydrolysis sol--gel method and partial biochemical enzymatic hydrolysis by cleavage sites (Asp-X and Glu-X) of the milk protein a-lactalbumin by using various organic surfactants, pH controller functions and divalent metallic salt ions as a binding site or ions ligand formation between two bio-based building blocks to form remarkable various new morphologies in appearance of nanoemulsions and clear green nanofluids, for application in the diet nutrition food science and pharmaceutical industry. The characterization by SEM, TEM, XRD and Raman spectroscopy (specific D and G bond in protein nanotubes) confirmed the novelty of these products.
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PMID:A synthetic garden of state of the art natural protein nanoarchitectures dispersed in nanofluids. 2183 Apr 85