Gene/Protein Disease Symptom Drug Enzyme Compound
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 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We measured intestinal 65Zn absorption and whole-body retention in postmenopausal women following a meal extrinsically labeled with 65Zn. The meal was consumed with 200 mL of milk or with a calcium phosphate supplement. Fifteen elderly (mean age 69) subjects were studied during three 12-d experimental periods in which they were fed either a basal diet containing 16 mg Zn or the basal diet supplemented either with 400 mL of milk or with dibasic calcium phosphate supplements containing an equivalent amount of calcium (468 mg) and phosphorus (360 mg). Measurements of fractional zinc absorption were made in 9 of the 15 subjects by a dual-isotope technique using 65Zn and 51Cr (as nonabsorbable fecal markers). Fractional zinc absorption was 0.22 +/- 0.06 (mean +/- SEM) after the standard meal, 0.23 +/- 0.06 with added milk and 0.22 +/- 0.03% with the added calcium phosphate supplement. The corresponding values for 65Zn retention in 15 subjects 12 d after dosing were 0.10 +/- 0.01% for all treatments. No significant effect of milk or calcium phosphate supplementation was observed on either 65Zn absorption or retention. We conclude that increased milk consumption with meals has no detrimental consequences on zinc nutriture in elderly women.
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PMID:Milk consumption and zinc retention in postmenopausal women. 232 92

The present study was conducted to investigate the sustained-release properties of Mimosa pudica seed mucilage. Matrix tablets of diclofenac sodium containing different proportions of mucilage and dibasic calcium phosphate as diluent were formulated by wet granulation method. The tablets had uniform physical appearance, average weight, drug content, and adequate hardness. The results of in vitro release conducted using USP type II dissolution rate apparatus, in a dissolution media comprising of 900 mL of 0.1 N HCl for 2 h followed by phosphate buffer (pH 6.8) for 24 h at 37 degrees C and 50 rpm, revealed that as the proportion of mucilage in the matrix was increased there was a corresponding decrease in the release of drug. Further, the matrix tablets were found to release the drug following Higuchi square root release kinetics, with the mechanism of release being diffusion for tablets containing higher proportion of mucilage and a combination of matrix erosion and diffusion for tablets containing smaller proportion of mucilage. The swelling and erosion studies revealed that, as the proportion of mucilage in tablets was increased, there was a corresponding increase in percent swelling and a decrease in percent erosion of tablets. The SEM photomicrographs showed gelling structures in tablets containing higher percentage of mucilage, while both pores and gelling structures were present on the surface of tablets containing smaller proportion of mucilage and commercial formulation. On comparative evaluation, the dissolution profile from formulation containing mucilage to drug in the proportion of 1:40 was found to be similar to the commercial sustained-release formulation of diclofenac.
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PMID:Evaluation of Mimosa pudica seed mucilage as sustained-release excipient. 1976 37

The aim of this study was to fabricate and characterize the novel hybrid organic/inorganic microparticles (MPs) to apply in bone regeneration. These hybrid MPs were fabricated using a scale-up method we have developed to increase the yield of chitosan (CS) MPs. The MPs were based on the CS and consist of inorganic components such as dibasic calcium phosphate (CaHPO(4)) or calcium carbonate (CaCO(3)). Tripolyphosphate (TPP) has been used as a cross-linking agent to form cross-links between the amine groups in CS and phosphate groups in TPP. Four types of hybrid MPs were fabricated: CS; CS-10%CaHPO(4); CS-20%CaHPO(4); CS-10% CaCO(3). SEM images revealed that all types of MPs were approximately spherical in shape and most of them were with a diameter range of 30-60 microm. XRD reveals the evidence of having CaHPO(4) or CaCO(3) in the CS-10%CaHPO(4), CS-20%CaHPO(4), or CS-10%CaCO(3) MPs, respectively. All types of MPs have shown the existence of cross-links according to FTIR. We have studied the mesenchymal stem cell (MSC) attachment on the surfaces of all types of MPs compared to control wells at 4, 8, 25, and 48 h. The attached MSCs on all types of MPs were increased more than two-fold at 48 h compared with that of 4 h. These hybrid MPs have a great potential to apply as a bone-void filler or bone tissue engineering scaffold to treat the bone defects.
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PMID:Fabrication and characterization of novel hybrid organic/inorganic microparticles to apply in bone regeneration. 1982 9