Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0432222 (SEM)
 47,337 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

WEB 2086, an antagonist of platelet-activating factor (PAF), was assessed against the cutaneous response in vivo and the aggregation of platelets ex vivo induced by PAF in a double-blind, placebo-controlled, crossover study in 12 normal male volunteers. Wheal-and-flare responses to intradermal PAF (200 ng) and histamine (1 microgram) were measured 1 hour after placebo or control administration. Wheal volumes were significantly reduced by 66% +/- 8.7% (mean +/- SEM), 86% +/- 8.3%, and 90% +/- 6.0% after 10, 40, and 100 mg of WEB 2086 compared to placebo administration (p less than 0.005). Flare responses were correspondingly inhibited by 66% +/- 8.3%, 82% +/- 8.7%, and 84% +/- 7.8% at 10, 40, and 100 mg of WEB 2086, respectively. Cutaneous responses to histamine were unaffected. Ex vivo platelet responses to PAF were significantly inhibited at all three doses of WEB 2086. Oral WEB 2086 is a potent and specific inhibitor of cutaneous and platelet responses to PAF in man.
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PMID:Inhibition of cutaneous and platelet responses to platelet-activating factor by oral WEB 2086 in man. 207 87

The effect of topical indomethacin on the weal and flare response was measured in 9 patients with chronic dermographic urticaria. An augmentation of dermographic wealing by topical indomethacin was shown with lowering of the weal threshold from 22.3 +/- 4.7 g/mm2 (mean +/- SEM, n = 9) to 16.4 +/- 3.8 (p < 0.005), but without a change in the shape of the force/response curve. Flare was increased by indomethacin particularly in patients with a greater lowering of the weal threshold. The augmentation of weal and flare by indomethacin in individual patients was not related to the degree of inhibition of UVB erythema in individual patients. These findings indicate that in chronic dermographic urticaria there is an abnormality involving eicosanoid production by a non-cyclo-oxygenase pathway. It is suggested that this acts by augmenting the effect of histamine on a new class of histamine receptor, the definition and antagonism of which should lead to better control of urticarial disease.
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PMID:Topical indomethacin aggravates the weal and flare response in chronic dermographic urticaria: evidence for a new class of histamine receptors. 809 60